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Gepubliceerd in: Journal of Autism and Developmental Disorders 8/2018

13-03-2018 | Original Paper

An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder

Auteurs: Alan S. Lewis, Gerrit Ian van Schalkwyk, Mayra Ortiz Lopez, Fred R. Volkmar, Marina R. Picciotto, Denis G. Sukhodolsky

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2018

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Abstract

Nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD.

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Metagegevens
Titel
An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder
Auteurs
Alan S. Lewis
Gerrit Ian van Schalkwyk
Mayra Ortiz Lopez
Fred R. Volkmar
Marina R. Picciotto
Denis G. Sukhodolsky
Publicatiedatum
13-03-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 8/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-018-3536-7