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Gepubliceerd in: Journal of Autism and Developmental Disorders 12/2017

08-07-2017 | S.I. : Anxiety in Autism Spectrum Disorders

Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety

Auteurs: John D. Herrington, Brenna B. Maddox, Connor M. Kerns, Keiran Rump, Julie A. Worley, Jennifer C. Bush, Alana J. McVey, Robert T. Schultz, Judith S. Miller

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2017

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Abstract

Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory.
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Metagegevens
Titel
Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety
Auteurs
John D. Herrington
Brenna B. Maddox
Connor M. Kerns
Keiran Rump
Julie A. Worley
Jennifer C. Bush
Alana J. McVey
Robert T. Schultz
Judith S. Miller
Publicatiedatum
08-07-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 12/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3206-1

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