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Gepubliceerd in: Journal of Autism and Developmental Disorders 1/2016

04-09-2015 | Original Paper

Altered Dynamics of the fMRI Response to Faces in Individuals with Autism

Auteurs: Natalia M. Kleinhans, Todd Richards, Jessica Greenson, Geraldine Dawson, Elizabeth Aylward

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2016

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Abstract

Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD.

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Literatuur
go back to reference Adolphs, R., & Tranel, D. (2003). Amygdala damage impairs emotion recognition from scenes only when they contain facial expressions. Neuropsychologia, 41(10), 1281–1289. PubMedCrossRef Adolphs, R., & Tranel, D. (2003). Amygdala damage impairs emotion recognition from scenes only when they contain facial expressions. Neuropsychologia, 41(10), 1281–1289. PubMedCrossRef
go back to reference Aylward, E. H., Minshew, N. J., Goldstein, G., Honeycutt, N. A., Augustine, A. M., Yates, K. O., et al. (1999). MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology, 53(9), 2145–2150. PubMedCrossRef Aylward, E. H., Minshew, N. J., Goldstein, G., Honeycutt, N. A., Augustine, A. M., Yates, K. O., et al. (1999). MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology, 53(9), 2145–2150. PubMedCrossRef
go back to reference Braeutigam, S., Bailey, A. J., & Swithenby, S. J. (2001). Task-dependent early latency (30–60 ms) visual processing of human faces and other objects. NeuroReport, 12(7), 1531–1536. PubMedCrossRef Braeutigam, S., Bailey, A. J., & Swithenby, S. J. (2001). Task-dependent early latency (30–60 ms) visual processing of human faces and other objects. NeuroReport, 12(7), 1531–1536. PubMedCrossRef
go back to reference Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., et al. (1996). Response and habituation of the human amygdala during visual processing of facial expression. Neuron, 17(5), 875–887. PubMedCrossRef Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., et al. (1996). Response and habituation of the human amygdala during visual processing of facial expression. Neuron, 17(5), 875–887. PubMedCrossRef
go back to reference Caspers, J., Zilles, K., Amunts, K., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2013). Functional characterization and differential coactivation patterns of two cytoarchitectonic visual areas on the human posterior fusiform gyrus. Human Brain Mapping. doi: 10.​1002/​hbm.​22364. Caspers, J., Zilles, K., Amunts, K., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2013). Functional characterization and differential coactivation patterns of two cytoarchitectonic visual areas on the human posterior fusiform gyrus. Human Brain Mapping. doi: 10.​1002/​hbm.​22364.
go back to reference Conturo, T. E., Williams, D. L., Smith, C. D., Gultepe, E., Akbudak, E., & Minshew, N. J. (2008). Neuronal fiber pathway abnormalities in autism: An initial MRI diffusion tensor tracking study of hippocampo-fusiform and amygdalo-fusiform pathways. Journal of International Neuropsychological Society, 14(6), 933–946. CrossRef Conturo, T. E., Williams, D. L., Smith, C. D., Gultepe, E., Akbudak, E., & Minshew, N. J. (2008). Neuronal fiber pathway abnormalities in autism: An initial MRI diffusion tensor tracking study of hippocampo-fusiform and amygdalo-fusiform pathways. Journal of International Neuropsychological Society, 14(6), 933–946. CrossRef
go back to reference Dawson, G., Toth, K., Abbott, R., Osterling, J., Munson, J., Estes, A., et al. (2004). Early social attention impairments in autism: Social orienting, joint attention, and attention to distress. Developmental Psychology, 40(2), 271–283. PubMedCrossRef Dawson, G., Toth, K., Abbott, R., Osterling, J., Munson, J., Estes, A., et al. (2004). Early social attention impairments in autism: Social orienting, joint attention, and attention to distress. Developmental Psychology, 40(2), 271–283. PubMedCrossRef
go back to reference Dawson, G., Webb, S. J., & McPartland, J. (2005). Understanding the nature of face processing impairment in autism: Insights from behavioral and electrophysiological studies. Developmental Neuropsychology, 27(3), 403–424. PubMedCrossRef Dawson, G., Webb, S. J., & McPartland, J. (2005). Understanding the nature of face processing impairment in autism: Insights from behavioral and electrophysiological studies. Developmental Neuropsychology, 27(3), 403–424. PubMedCrossRef
go back to reference Eimer, M., & Holmes, A. (2002). An ERP study on the time course of emotional face processing. NeuroReport, 13(4), 427–431. PubMedCrossRef Eimer, M., & Holmes, A. (2002). An ERP study on the time course of emotional face processing. NeuroReport, 13(4), 427–431. PubMedCrossRef
go back to reference Endo, T., Shioiri, T., Kitamura, H., Kimura, T., Endo, S., Masuzawa, N., et al. (2007). Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders. Biological Psychiatry, 62(9), 1030–1037. PubMedCrossRef Endo, T., Shioiri, T., Kitamura, H., Kimura, T., Endo, S., Masuzawa, N., et al. (2007). Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders. Biological Psychiatry, 62(9), 1030–1037. PubMedCrossRef
go back to reference Fang, F., Murray, S. O., Kersten, D., & He, S. (2005). Orientation-tuned FMRI adaptation in human visual cortex. Journal of Neurophysiology, 94(6), 4188–4195. PubMedCrossRef Fang, F., Murray, S. O., Kersten, D., & He, S. (2005). Orientation-tuned FMRI adaptation in human visual cortex. Journal of Neurophysiology, 94(6), 4188–4195. PubMedCrossRef
go back to reference Fischer, H., Wright, C. I., Whalen, P. J., McInerney, S. C., Shin, L. M., & Rauch, S. L. (2003). Brain habituation during repeated exposure to fearful and neutral faces: A functional MRI study. Brain Research Bulletin, 59(5), 387–392. PubMedCrossRef Fischer, H., Wright, C. I., Whalen, P. J., McInerney, S. C., Shin, L. M., & Rauch, S. L. (2003). Brain habituation during repeated exposure to fearful and neutral faces: A functional MRI study. Brain Research Bulletin, 59(5), 387–392. PubMedCrossRef
go back to reference Gabis, L., Wei, H., Azizian, A., DeVincent, C., Tudorica, A., Kesner-Baruch, Y., et al. (2008). 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders. Journal of Child Neurology, 23(7), 766–774. PubMedCrossRef Gabis, L., Wei, H., Azizian, A., DeVincent, C., Tudorica, A., Kesner-Baruch, Y., et al. (2008). 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders. Journal of Child Neurology, 23(7), 766–774. PubMedCrossRef
go back to reference Grelotti, D. J., Gauthier, I., & Schultz, R. T. (2002). Social interest and the development of cortical face specialization: What autism teaches us about face processing. Developmental Psychobiology, 40(3), 213–225. PubMedCrossRef Grelotti, D. J., Gauthier, I., & Schultz, R. T. (2002). Social interest and the development of cortical face specialization: What autism teaches us about face processing. Developmental Psychobiology, 40(3), 213–225. PubMedCrossRef
go back to reference Grill-Spector, K., Henson, R., & Martin, A. (2006). Repetition and the brain: Neural models of stimulus-specific effects. Trends in Cognitive Science, 10(1), 14–23. CrossRef Grill-Spector, K., Henson, R., & Martin, A. (2006). Repetition and the brain: Neural models of stimulus-specific effects. Trends in Cognitive Science, 10(1), 14–23. CrossRef
go back to reference Hanley, J. A., & McNeil, B. J. (1982). The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology, 143, 29–36. PubMedCrossRef Hanley, J. A., & McNeil, B. J. (1982). The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology, 143, 29–36. PubMedCrossRef
go back to reference Honeycutt, N. A., Smith, P. D., Aylward, E., Li, Q., Chan, M., Barta, P. E., et al. (1998). Mesial temporal lobe measurements on magnetic resonance imaging scans. Psychiatry Research, 83(2), 85–94. PubMedCrossRef Honeycutt, N. A., Smith, P. D., Aylward, E., Li, Q., Chan, M., Barta, P. E., et al. (1998). Mesial temporal lobe measurements on magnetic resonance imaging scans. Psychiatry Research, 83(2), 85–94. PubMedCrossRef
go back to reference Ishai, A., Pessoa, L., Bikle, P. C., & Ungerleider, L. G. (2004). Repetition suppression of faces is modulated by emotion. Proceedings of the National Academy of Sciences of the United States of America, 101(26), 9827–9832. PubMedPubMedCentralCrossRef Ishai, A., Pessoa, L., Bikle, P. C., & Ungerleider, L. G. (2004). Repetition suppression of faces is modulated by emotion. Proceedings of the National Academy of Sciences of the United States of America, 101(26), 9827–9832. PubMedPubMedCentralCrossRef
go back to reference Johnson, M. H. (2005). Subcortical face processing. Nature Reviews Neuroscience, 6(10), 766–774. PubMedCrossRef Johnson, M. H. (2005). Subcortical face processing. Nature Reviews Neuroscience, 6(10), 766–774. PubMedCrossRef
go back to reference Kenworthy, L., Yerys, B. E., Weinblatt, R., Abrams, D. N., & Wallace, G. L. (2013). Motor demands impact speed of information processing in autism spectrum disorders. Neuropsychology, 27(5), 529–536. PubMedPubMedCentralCrossRef Kenworthy, L., Yerys, B. E., Weinblatt, R., Abrams, D. N., & Wallace, G. L. (2013). Motor demands impact speed of information processing in autism spectrum disorders. Neuropsychology, 27(5), 529–536. PubMedPubMedCentralCrossRef
go back to reference Kleinhans, N. M., Johnson, L. C., Richards, T., Mahurin, R., Greenson, J., Dawson, G., et al. (2009). Reduced neural habituation in the amygdala and social impairments in autism spectrum disorders. American Journal of Psychiatry, 166(4), 467–475. PubMedCrossRef Kleinhans, N. M., Johnson, L. C., Richards, T., Mahurin, R., Greenson, J., Dawson, G., et al. (2009). Reduced neural habituation in the amygdala and social impairments in autism spectrum disorders. American Journal of Psychiatry, 166(4), 467–475. PubMedCrossRef
go back to reference Kleinhans, N. M., Richards, T., Johnson, L. C., Weaver, K. E., Greenson, J., Dawson, G., et al. (2011). fMRI evidence of neural abnormalities in the subcortical face processing system in ASD. Neuroimage, 54(1), 697–704. PubMedPubMedCentralCrossRef Kleinhans, N. M., Richards, T., Johnson, L. C., Weaver, K. E., Greenson, J., Dawson, G., et al. (2011). fMRI evidence of neural abnormalities in the subcortical face processing system in ASD. Neuroimage, 54(1), 697–704. PubMedPubMedCentralCrossRef
go back to reference Kleinhans, N. M., Richards, T., Sterling, L., Stegbauer, K. C., Mahurin, R., Johnson, L. C., et al. (2008). Abnormal functional connectivity in autism spectrum disorders during face processing. Brain, 131(Pt 4), 1000–1012. PubMedCrossRef Kleinhans, N. M., Richards, T., Sterling, L., Stegbauer, K. C., Mahurin, R., Johnson, L. C., et al. (2008). Abnormal functional connectivity in autism spectrum disorders during face processing. Brain, 131(Pt 4), 1000–1012. PubMedCrossRef
go back to reference Kleinhans, N. M., Richards, T., Weaver, K., Johnson, L. C., Greenson, J., Dawson, G., et al. (2010). Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders. Neuropsychologia, 48(12), 3665–3670. PubMedPubMedCentralCrossRef Kleinhans, N. M., Richards, T., Weaver, K., Johnson, L. C., Greenson, J., Dawson, G., et al. (2010). Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders. Neuropsychologia, 48(12), 3665–3670. PubMedPubMedCentralCrossRef
go back to reference Livingstone, M., & Hubel, D. (1988). Segregation of form, color, movement, and depth: Anatomy, physiology, and perception. Science, 240(4853), 740–749. PubMedCrossRef Livingstone, M., & Hubel, D. (1988). Segregation of form, color, movement, and depth: Anatomy, physiology, and perception. Science, 240(4853), 740–749. PubMedCrossRef
go back to reference Lord, C., Risi, S., Lambrecht, L., Cook, E., Leventhal, B., DiLavore, P., et al. (2000). The Autism Diagnostic Observation Schedule–Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. PubMedCrossRef Lord, C., Risi, S., Lambrecht, L., Cook, E., Leventhal, B., DiLavore, P., et al. (2000). The Autism Diagnostic Observation Schedule–Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. PubMedCrossRef
go back to reference Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685. PubMedCrossRef Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685. PubMedCrossRef
go back to reference Merigan, W. H., & Maunsell, J. H. (1993). How parallel are the primate visual pathways? Annual Review of Neuroscience, 16, 369–402. PubMedCrossRef Merigan, W. H., & Maunsell, J. H. (1993). How parallel are the primate visual pathways? Annual Review of Neuroscience, 16, 369–402. PubMedCrossRef
go back to reference Munson, J., Dawson, G., Abbott, R., Faja, S., Webb, S. J., Friedman, S. D., et al. (2006). Amygdalar volume and behavioral development in autism. Archives of General Psychiatry, 63(6), 686–693. PubMedCrossRef Munson, J., Dawson, G., Abbott, R., Faja, S., Webb, S. J., Friedman, S. D., et al. (2006). Amygdalar volume and behavioral development in autism. Archives of General Psychiatry, 63(6), 686–693. PubMedCrossRef
go back to reference Murray, S. O., Olman, C. A., & Kersten, D. (2006). Spatially specific FMRI repetition effects in human visual cortex. Journal of Neurophysiology, 95(4), 2439–2445. PubMedCrossRef Murray, S. O., Olman, C. A., & Kersten, D. (2006). Spatially specific FMRI repetition effects in human visual cortex. Journal of Neurophysiology, 95(4), 2439–2445. PubMedCrossRef
go back to reference Nacewicz, B. M., Dalton, K. M., Johnstone, T., Long, M. T., McAuliff, E. M., Oakes, T. R., et al. (2006). Amygdala volume and nonverbal social impairment in adolescent and adult males with autism. Archives of General Psychiatry, 63(12), 1417–1428. PubMedCrossRef Nacewicz, B. M., Dalton, K. M., Johnstone, T., Long, M. T., McAuliff, E. M., Oakes, T. R., et al. (2006). Amygdala volume and nonverbal social impairment in adolescent and adult males with autism. Archives of General Psychiatry, 63(12), 1417–1428. PubMedCrossRef
go back to reference Otsuka, H., Harada, M., Mori, K., Hisaoka, S., & Nishitani, H. (1999). Brain metabolites in the hippocampus-amygdala region and cerebellum in autism: An 1H-MR spectroscopy study. Neuroradiology, 41(7), 517–519. PubMedCrossRef Otsuka, H., Harada, M., Mori, K., Hisaoka, S., & Nishitani, H. (1999). Brain metabolites in the hippocampus-amygdala region and cerebellum in autism: An 1H-MR spectroscopy study. Neuroradiology, 41(7), 517–519. PubMedCrossRef
go back to reference Page, L. A., Daly, E., Schmitz, N., Simmons, A., Toal, F., Deeley, Q., et al. (2006). In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism. American Journal of Psychiatry, 163, 2189–2192. PubMedCrossRef Page, L. A., Daly, E., Schmitz, N., Simmons, A., Toal, F., Deeley, Q., et al. (2006). In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism. American Journal of Psychiatry, 163, 2189–2192. PubMedCrossRef
go back to reference Pellicano, E., Jeffery, L., Burr, D., & Rhodes, G. (2007). Abnormal adaptive face-coding mechanisms in children with autism spectrum disorder. Current Biology, 17(17), 1508–1512. PubMedCrossRef Pellicano, E., Jeffery, L., Burr, D., & Rhodes, G. (2007). Abnormal adaptive face-coding mechanisms in children with autism spectrum disorder. Current Biology, 17(17), 1508–1512. PubMedCrossRef
go back to reference Pierce, K., Muller, R. A., Ambrose, J., Allen, G., & Courchesne, E. (2001). Face processing occurs outside the fusiform ‘face area’ in autism: Evidence from functional MRI. Brain, 124(Pt 10), 2059–2073. PubMedCrossRef Pierce, K., Muller, R. A., Ambrose, J., Allen, G., & Courchesne, E. (2001). Face processing occurs outside the fusiform ‘face area’ in autism: Evidence from functional MRI. Brain, 124(Pt 10), 2059–2073. PubMedCrossRef
go back to reference Pourtois, G., Thut, G., Grave de Peralta, R., Michel, C., & Vuilleumier, P. (2005). Two electrophysiological stages of spatial orienting towards fearful faces: Early temporo-parietal activation preceding gain control in extrastriate visual cortex. Neuroimage, 26(1), 149–163. PubMedCrossRef Pourtois, G., Thut, G., Grave de Peralta, R., Michel, C., & Vuilleumier, P. (2005). Two electrophysiological stages of spatial orienting towards fearful faces: Early temporo-parietal activation preceding gain control in extrastriate visual cortex. Neuroimage, 26(1), 149–163. PubMedCrossRef
go back to reference Prescott, S. A. (1998). Interactions between depression and facilitation within neural networks: Updating the dual-process theory of plasticity. Learning Memory, 5, 446–466. PubMedPubMedCentral Prescott, S. A. (1998). Interactions between depression and facilitation within neural networks: Updating the dual-process theory of plasticity. Learning Memory, 5, 446–466. PubMedPubMedCentral
go back to reference Schumann, C. M., & Amaral, D. G. (2006). Stereological analysis of amygdala neuron number in autism. Journal of Neuroscience, 26(29), 7674–7679. PubMedCrossRef Schumann, C. M., & Amaral, D. G. (2006). Stereological analysis of amygdala neuron number in autism. Journal of Neuroscience, 26(29), 7674–7679. PubMedCrossRef
go back to reference Schumann, C. M., Hamstra, J., Goodlin-Jones, B. L., Lotspeich, L. J., Kwon, H., Buonocore, M. H., et al. (2004). The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. Journal of Neuroscience, 24(28), 6392–6401. PubMedCrossRef Schumann, C. M., Hamstra, J., Goodlin-Jones, B. L., Lotspeich, L. J., Kwon, H., Buonocore, M. H., et al. (2004). The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. Journal of Neuroscience, 24(28), 6392–6401. PubMedCrossRef
go back to reference Simion, F., Leo, I., Turati, C., Valenza, E., & Dalla Barba, B. (2007). How face specialization emerges in the first months of life. Progress in Brain Research, 164, 169–185. PubMedCrossRef Simion, F., Leo, I., Turati, C., Valenza, E., & Dalla Barba, B. (2007). How face specialization emerges in the first months of life. Progress in Brain Research, 164, 169–185. PubMedCrossRef
go back to reference Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., et al. (2002). Brain structural abnormalities in young children with autism spectrum disorder. Neurology, 59(2), 184–192. PubMedCrossRef Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., et al. (2002). Brain structural abnormalities in young children with autism spectrum disorder. Neurology, 59(2), 184–192. PubMedCrossRef
go back to reference Streit, M., Dammers, J., Simsek-Kraues, S., Brinkmeyer, J., Wolwer, W., & Ioannides, A. (2003). Time course of regional brain activations during facial emotion recognition in humans. Neuroscience Letters, 342(1–2), 101–104. PubMedCrossRef Streit, M., Dammers, J., Simsek-Kraues, S., Brinkmeyer, J., Wolwer, W., & Ioannides, A. (2003). Time course of regional brain activations during facial emotion recognition in humans. Neuroscience Letters, 342(1–2), 101–104. PubMedCrossRef
go back to reference Swartz, J. R., Wiggins, J. L., Carrasco, M., Lord, C., & Monk, C. S. (2013). Amygdala habituation and prefrontal functional connectivity in youth with autism spectrum disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 52(1), 84–93. PubMedPubMedCentralCrossRef Swartz, J. R., Wiggins, J. L., Carrasco, M., Lord, C., & Monk, C. S. (2013). Amygdala habituation and prefrontal functional connectivity in youth with autism spectrum disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 52(1), 84–93. PubMedPubMedCentralCrossRef
go back to reference Thompson, R. F., & Spencer, W. A. (1966). Habituation: A model phenomenon for the study of neuronal substrates of behavior. Psychological Review, 73(1), 16–43. PubMedCrossRef Thompson, R. F., & Spencer, W. A. (1966). Habituation: A model phenomenon for the study of neuronal substrates of behavior. Psychological Review, 73(1), 16–43. PubMedCrossRef
go back to reference Verbaten, M. N., Roelofs, J. W., van Engeland, H., Kenemans, J. K., & Slangen, J. L. (1991). Abnormal visual event-related potentials of autistic children. Journal of Autism and Developmental Disorders, 21(4), 449–470. PubMedCrossRef Verbaten, M. N., Roelofs, J. W., van Engeland, H., Kenemans, J. K., & Slangen, J. L. (1991). Abnormal visual event-related potentials of autistic children. Journal of Autism and Developmental Disorders, 21(4), 449–470. PubMedCrossRef
go back to reference Vuilleumier, P., Armony, J. L., Driver, J., & Dolan, R. J. (2003). Distinct spatial frequency sensitivities for processing faces and emotional expressions. Nature Neuroscience, 6(6), 624–631. PubMedCrossRef Vuilleumier, P., Armony, J. L., Driver, J., & Dolan, R. J. (2003). Distinct spatial frequency sensitivities for processing faces and emotional expressions. Nature Neuroscience, 6(6), 624–631. PubMedCrossRef
go back to reference Webb, S. J., Jones, E. J., Merkle, K., Namkung, J., Toth, K., Greenson, J., et al. (2010). Toddlers with elevated autism symptoms show slowed habituation to faces. Child Neuropsychol, 16(3), 255–278. PubMedPubMedCentralCrossRef Webb, S. J., Jones, E. J., Merkle, K., Namkung, J., Toth, K., Greenson, J., et al. (2010). Toddlers with elevated autism symptoms show slowed habituation to faces. Child Neuropsychol, 16(3), 255–278. PubMedPubMedCentralCrossRef
go back to reference Wilson, F. A., & Rolls, E. T. (1993). The effects of stimulus novelty and familiarity on neuronal activity in the amygdala of monkeys performing recognition memory tasks. Experimental Brain Research, 93(3), 367–382. PubMedCrossRef Wilson, F. A., & Rolls, E. T. (1993). The effects of stimulus novelty and familiarity on neuronal activity in the amygdala of monkeys performing recognition memory tasks. Experimental Brain Research, 93(3), 367–382. PubMedCrossRef
go back to reference Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001). Temporal autocorrelation in univariate linear modeling of FMRI data. Neuroimage, 14(6), 1370–1386. PubMedCrossRef Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001). Temporal autocorrelation in univariate linear modeling of FMRI data. Neuroimage, 14(6), 1370–1386. PubMedCrossRef
Metagegevens
Titel
Altered Dynamics of the fMRI Response to Faces in Individuals with Autism
Auteurs
Natalia M. Kleinhans
Todd Richards
Jessica Greenson
Geraldine Dawson
Elizabeth Aylward
Publicatiedatum
04-09-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-015-2565-8