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Gepubliceerd in: Journal of Autism and Developmental Disorders 1/2016

04-09-2015 | Original Paper

Altered Dynamics of the fMRI Response to Faces in Individuals with Autism

Auteurs: Natalia M. Kleinhans, Todd Richards, Jessica Greenson, Geraldine Dawson, Elizabeth Aylward

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2016

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Abstract

Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD.
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Metagegevens
Titel
Altered Dynamics of the fMRI Response to Faces in Individuals with Autism
Auteurs
Natalia M. Kleinhans
Todd Richards
Jessica Greenson
Geraldine Dawson
Elizabeth Aylward
Publicatiedatum
04-09-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-015-2565-8

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