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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-02-2015 | Original Paper

Alpha Asymmetry in Infants at Risk for Autism Spectrum Disorders

Auteurs: Laurel Gabard-Durnam, Adrienne L. Tierney, Vanessa Vogel-Farley, Helen Tager-Flusberg, Charles A. Nelson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2015

Abstract

An emerging focus of research on autism spectrum disorder (ASD) targets the identification of early-developing ASD endophenotypes using infant siblings of affected children. One potential neural endophenotype is resting frontal electroencephalogram (EEG) alpha asymmetry, a metric of hemispheric organization. Here, we examined the development of frontal EEG alpha asymmetry in ASD high-risk and low-risk infant populations. Our findings demonstrate that low and high-risk infants show different patterns of alpha asymmetry at 6 months of age and opposite growth trajectories in asymmetry over the following 12 months. These results support the candidacy of alpha asymmetry as an early neural ASD endophenotype.

vorige artikel Autonomic Dysregulation During Sensory Stimulation in Children with Autism Spectrum Disorder

volgende artikel Cardiac Reactivity and Stimulant Use in Adolescents with Autism Spectrum Disorders with Comorbid ADHD Versus ADHD

At the start of the project, we used the 64-channel Geodesic Sensor Nets at each testing session, but 2 years into the project, we changed to the 128-channel HydroCell Geodesic Sensor nets. In order to ensure that this equipment change did not influence our results, we assessed whether there were any differences in asymmetry scores between the two nets, but found no statistically significant difference (t(41) = 0.68, p = 0.500). We also determined that the type of net used was distributed equally across age and risk groups.

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Titel: Alpha Asymmetry in Infants at Risk for Autism Spectrum Disorders
Auteurs: Laurel Gabard-Durnam
Adrienne L. Tierney
Vanessa Vogel-Farley
Helen Tager-Flusberg
Charles A. Nelson
Publicatiedatum: 01-02-2015
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 2/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-013-1926-4

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