Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2015

01-02-2015 | Original Paper

Alpha Asymmetry in Infants at Risk for Autism Spectrum Disorders

Auteurs: Laurel Gabard-Durnam, Adrienne L. Tierney, Vanessa Vogel-Farley, Helen Tager-Flusberg, Charles A. Nelson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2015

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

An emerging focus of research on autism spectrum disorder (ASD) targets the identification of early-developing ASD endophenotypes using infant siblings of affected children. One potential neural endophenotype is resting frontal electroencephalogram (EEG) alpha asymmetry, a metric of hemispheric organization. Here, we examined the development of frontal EEG alpha asymmetry in ASD high-risk and low-risk infant populations. Our findings demonstrate that low and high-risk infants show different patterns of alpha asymmetry at 6 months of age and opposite growth trajectories in asymmetry over the following 12 months. These results support the candidacy of alpha asymmetry as an early neural ASD endophenotype.

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Psychologie Totaal

Met BSL Psychologie Totaal blijf je als professional steeds op de hoogte van de nieuwste ontwikkelingen binnen jouw vak. Met het online abonnement heb je toegang tot een groot aantal boeken, protocollen, vaktijdschriften en e-learnings op het gebied van psychologie en psychiatrie. Zo kun je op je gemak en wanneer het jou het beste uitkomt verdiepen in jouw vakgebied.

Voetnoten
1
At the start of the project, we used the 64-channel Geodesic Sensor Nets at each testing session, but 2 years into the project, we changed to the 128-channel HydroCell Geodesic Sensor nets. In order to ensure that this equipment change did not influence our results, we assessed whether there were any differences in asymmetry scores between the two nets, but found no statistically significant difference (t(41) = 0.68, p = 0.500). We also determined that the type of net used was distributed equally across age and risk groups.
 
Literatuur
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Association. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Association.
go back to reference Anokhin, A., Heath, A., & Meyers, E. (2006). Genetic and environmental influences on frontal EEG asymmetry: A twin study. Biological Psychology, 71, 289–295. PubMedCentralPubMedCrossRef Anokhin, A., Heath, A., & Meyers, E. (2006). Genetic and environmental influences on frontal EEG asymmetry: A twin study. Biological Psychology, 71, 289–295. PubMedCentralPubMedCrossRef
go back to reference Baio, J. (2012). Prevalence of autism spectrum disorders-Autism and developmental disabilities monitoring network, 14 sites, United States, 2008. Centers for Disease Control and Prevention Surveillance Summaries, 61, 1–19. Baio, J. (2012). Prevalence of autism spectrum disorders-Autism and developmental disabilities monitoring network, 14 sites, United States, 2008. Centers for Disease Control and Prevention Surveillance Summaries, 61, 1–19.
go back to reference Basar E. (1998). Brain Function and Oscillations. In Brain Oscillations: Principles and Approaches, Berlin: Springer. Basar E. (1998). Brain Function and Oscillations. In Brain Oscillations: Principles and Approaches, Berlin: Springer.
go back to reference Bryson, S., Zwaigenbaum, L., Brian, J., Roberts, W., Szatmari, P., Rombough, V., et al. (2007). A prospective case series of high-risk infants who developed autism. Journal of Autism and Developmental Disorders, 37, 12–24. PubMedCrossRef Bryson, S., Zwaigenbaum, L., Brian, J., Roberts, W., Szatmari, P., Rombough, V., et al. (2007). A prospective case series of high-risk infants who developed autism. Journal of Autism and Developmental Disorders, 37, 12–24. PubMedCrossRef
go back to reference Cassel, T. D., Messinger, D. S., Ibanez, L. V., Haltigan, J. D., Acosta, S. I., & Buchman, A. C. (2007). Early social and emotional communication in the infant siblings of children with autism spectrum disorders: An examination of the broad phenotype. Journal of Autism Developmental Disorders, 37, 122–132. PubMedCrossRef Cassel, T. D., Messinger, D. S., Ibanez, L. V., Haltigan, J. D., Acosta, S. I., & Buchman, A. C. (2007). Early social and emotional communication in the infant siblings of children with autism spectrum disorders: An examination of the broad phenotype. Journal of Autism Developmental Disorders, 37, 122–132. PubMedCrossRef
go back to reference Cook, I. A., O’Hara, R., Uijtdehaage, S. H., Mandelkern, M., & Leuchter, A. F. (1998). Assessing the accuracy of topographic EEG mapping for determining local brain function. Electroencephalography and Clinical Neurophysiology, 107, 408–414. PubMedCrossRef Cook, I. A., O’Hara, R., Uijtdehaage, S. H., Mandelkern, M., & Leuchter, A. F. (1998). Assessing the accuracy of topographic EEG mapping for determining local brain function. Electroencephalography and Clinical Neurophysiology, 107, 408–414. PubMedCrossRef
go back to reference Davidson, R. J. (1993). Parsing affective space: Perspectives from neuropsychology and psychophysiology. Neuropsychology, 7, 464–475. CrossRef Davidson, R. J. (1993). Parsing affective space: Perspectives from neuropsychology and psychophysiology. Neuropsychology, 7, 464–475. CrossRef
go back to reference Elsabbagh, M., & Johnson, M. (2007). Infancy and autism: Progress, prospects, and challenges. Progress in Brain Research, 164, 355–383. PubMedCrossRef Elsabbagh, M., & Johnson, M. (2007). Infancy and autism: Progress, prospects, and challenges. Progress in Brain Research, 164, 355–383. PubMedCrossRef
go back to reference Elsabbagh, M., Volein, A., Csibra, G., Holmboe, K., Garwood, H., Tucker, L., et al. (2009a). Neural correlates of eye gaze processing in the infant broader autism phenotype. Biological Psychiatry, 65, 31–38. PubMedCrossRef Elsabbagh, M., Volein, A., Csibra, G., Holmboe, K., Garwood, H., Tucker, L., et al. (2009a). Neural correlates of eye gaze processing in the infant broader autism phenotype. Biological Psychiatry, 65, 31–38. PubMedCrossRef
go back to reference Elsabbagh, M., Volein, A., Holmboe, K., Tucker, L., Csibra, G., Baron-Cohen, S., et al. (2009b). Visual orienting in the broader autism phenotype: Disengagement and facilitation. Journal of Child Psychology and Psychiatry, 50, 637–642. PubMedCentralPubMedCrossRef Elsabbagh, M., Volein, A., Holmboe, K., Tucker, L., Csibra, G., Baron-Cohen, S., et al. (2009b). Visual orienting in the broader autism phenotype: Disengagement and facilitation. Journal of Child Psychology and Psychiatry, 50, 637–642. PubMedCentralPubMedCrossRef
go back to reference Fox, N. A., Calkins, S. D., & Bell, M. A. (1994). Neural plasticity and development in the first two years of life: Evidence from cognitive and socioemotional domains of research. Developmental Psychopathology, 6, 677–696. CrossRef Fox, N. A., Calkins, S. D., & Bell, M. A. (1994). Neural plasticity and development in the first two years of life: Evidence from cognitive and socioemotional domains of research. Developmental Psychopathology, 6, 677–696. CrossRef
go back to reference Fox, N. A., Henderson, H. A., Rubin, K. H., Calkins, S. D., & Schmidt, L. A. (2001). Continuity and discontinuity of behavioral inhibition and exhuberance: Psychophysiological and behavioral influences across the first four years of life. Child Development, 72, 1–21. PubMedCrossRef Fox, N. A., Henderson, H. A., Rubin, K. H., Calkins, S. D., & Schmidt, L. A. (2001). Continuity and discontinuity of behavioral inhibition and exhuberance: Psychophysiological and behavioral influences across the first four years of life. Child Development, 72, 1–21. PubMedCrossRef
go back to reference Gamliel, I., Yirmiya, N., Jaffe, D. H., Manor, O., & Sigman, M. (2009). Developmental trajectories in siblings of children with autism: Cognition and language from 4 months to 7 years. Journal of Autism and Developmental Disorders, 39, 1131–1144. PubMedCentralPubMedCrossRef Gamliel, I., Yirmiya, N., Jaffe, D. H., Manor, O., & Sigman, M. (2009). Developmental trajectories in siblings of children with autism: Cognition and language from 4 months to 7 years. Journal of Autism and Developmental Disorders, 39, 1131–1144. PubMedCentralPubMedCrossRef
go back to reference Garon, N., Bryson, S. E., Zwaigenbaum, L., Smith, I. M., Brian, J., Roberts, W., et al. (2009). Temperament and its relationship to autistic symptoms in a high-risk infant sib cohort. Journal of Abnormal Child Psychology, 37, 59–78. PubMedCrossRef Garon, N., Bryson, S. E., Zwaigenbaum, L., Smith, I. M., Brian, J., Roberts, W., et al. (2009). Temperament and its relationship to autistic symptoms in a high-risk infant sib cohort. Journal of Abnormal Child Psychology, 37, 59–78. PubMedCrossRef
go back to reference Gottesman, I., & Gould, T. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636–645. PubMedCrossRef Gottesman, I., & Gould, T. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636–645. PubMedCrossRef
go back to reference Hall, M., Schulze, K., Rijsdijk, F., Kalidindi, S., McDonald, C., Bramon, E., et al. (2009). Are auditory P300 and duration MMN heritable and putative endophenotypes of psychotic bipolar disorder? A Maudsley bipolar twin and family study. Psycholocial Medicine, 39, 1277–1287. CrossRef Hall, M., Schulze, K., Rijsdijk, F., Kalidindi, S., McDonald, C., Bramon, E., et al. (2009). Are auditory P300 and duration MMN heritable and putative endophenotypes of psychotic bipolar disorder? A Maudsley bipolar twin and family study. Psycholocial Medicine, 39, 1277–1287. CrossRef
go back to reference Ibanez, L. V., Messinger, D. S., Newell, L., Lambert, B., & Sheskin, M. (2008). Visual disengagement in the infant siblings of children with an autism spectrum disorder (ASD). Autism, 12, 473–485. PubMedCentralPubMedCrossRef Ibanez, L. V., Messinger, D. S., Newell, L., Lambert, B., & Sheskin, M. (2008). Visual disengagement in the infant siblings of children with an autism spectrum disorder (ASD). Autism, 12, 473–485. PubMedCentralPubMedCrossRef
go back to reference Iverson, J. M., & Wozniak, R. H. (2007). Variation in the vocal-motor development in infant siblings of children with autism. Journal of Autism Developmental Disorders, 37, 158–170. PubMedCentralPubMedCrossRef Iverson, J. M., & Wozniak, R. H. (2007). Variation in the vocal-motor development in infant siblings of children with autism. Journal of Autism Developmental Disorders, 37, 158–170. PubMedCentralPubMedCrossRef
go back to reference Kogan, M., Blumberg, S., Schieve, L., Boyle, C., Perrin, J., Chandour, R., et al. (2009). Prevalence of parent-reported diagnosis of Autism Spectrum Disorder among children in the US, 2007. Pediatrics, 124, 1395–1403. PubMedCrossRef Kogan, M., Blumberg, S., Schieve, L., Boyle, C., Perrin, J., Chandour, R., et al. (2009). Prevalence of parent-reported diagnosis of Autism Spectrum Disorder among children in the US, 2007. Pediatrics, 124, 1395–1403. PubMedCrossRef
go back to reference Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule—Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223. PubMedCrossRef Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule—Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223. PubMedCrossRef
go back to reference Luyster, R., Wagner, J., Vogel-Farley, V., Tager-Flusberg, H., & Nelson, C. A. (2011). Neural correlates of familiar and unfamiliar face processing in infants at risk for autism spectrum disorders. Brain Topography, 24, 220–228. PubMedCentralPubMedCrossRef Luyster, R., Wagner, J., Vogel-Farley, V., Tager-Flusberg, H., & Nelson, C. A. (2011). Neural correlates of familiar and unfamiliar face processing in infants at risk for autism spectrum disorders. Brain Topography, 24, 220–228. PubMedCentralPubMedCrossRef
go back to reference Makeig, S., & Delorme, A. (2004). EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Journal of Neuroscience Methods, 134, 9–21. PubMedCrossRef Makeig, S., & Delorme, A. (2004). EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Journal of Neuroscience Methods, 134, 9–21. PubMedCrossRef
go back to reference Marshall, P. J., Bar-Haim, Y., & Fox, N. A. (2002). Development of the EEG from 5 months to 4 years of age. Clinical Neurophysiology, 113, 1199–1208. PubMedCrossRef Marshall, P. J., Bar-Haim, Y., & Fox, N. A. (2002). Development of the EEG from 5 months to 4 years of age. Clinical Neurophysiology, 113, 1199–1208. PubMedCrossRef
go back to reference McCleery, J. P., Akshoomoff, N., Dobkins, K. R., & Carver, L. J. (2009). Atypical face versus object processing and hemispheric asymmetries in 10-month-old infants at risk for autism. Biological Psychiatry, 66, 950–957. PubMedCentralPubMedCrossRef McCleery, J. P., Akshoomoff, N., Dobkins, K. R., & Carver, L. J. (2009). Atypical face versus object processing and hemispheric asymmetries in 10-month-old infants at risk for autism. Biological Psychiatry, 66, 950–957. PubMedCentralPubMedCrossRef
go back to reference Ozonoff, S., Young, G.S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., et al. (2011). Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics, 128 (epub ahead of print). doi: 10.​1542/​peds.​2010-2825. Ozonoff, S., Young, G.S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., et al. (2011). Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics, 128 (epub ahead of print). doi: 10.​1542/​peds.​2010-2825.
go back to reference Redcay, E., & Courchesne, E. (2005). When is the brain enlarged in Autism? A meta-analysis of all brain size reports. Biological Psychiatry, 58, 1–9. PubMedCrossRef Redcay, E., & Courchesne, E. (2005). When is the brain enlarged in Autism? A meta-analysis of all brain size reports. Biological Psychiatry, 58, 1–9. PubMedCrossRef
go back to reference Shagass, C. (1972). Electrical activity ofthe brain. In N. S. Greenfield & R. A. Sternbach (Eds.), Handbook ofpsychophysiology (pp. 263–328). New York: Holt, Rinehart and Winston. Shagass, C. (1972). Electrical activity ofthe brain. In N. S. Greenfield & R. A. Sternbach (Eds.), Handbook ofpsychophysiology (pp. 263–328). New York: Holt, Rinehart and Winston.
go back to reference Singer, J., & Willett, J. (2003). Applied Longitudinal Data Analysis. New York: Oxford University Press. CrossRef Singer, J., & Willett, J. (2003). Applied Longitudinal Data Analysis. New York: Oxford University Press. CrossRef
go back to reference Spencer, M., Holt, R., Chura, L., Caler, A., Suckling, J., Bullmore, E., et al. (2012). Atypical activation during the embedded figures task as a functional magnetic resonance imaging endophenotype of autism. Brain, 135, 3469–3480. PubMedCentralPubMedCrossRef Spencer, M., Holt, R., Chura, L., Caler, A., Suckling, J., Bullmore, E., et al. (2012). Atypical activation during the embedded figures task as a functional magnetic resonance imaging endophenotype of autism. Brain, 135, 3469–3480. PubMedCentralPubMedCrossRef
go back to reference Stewart, J., Bismark, A., Towers, D., Coan, J., & Allen, J. B. (2010). Resting frontal EEG asymmetry as an endophenotype for depression risk: Sex-specific patterns of frontal brain asymmetry. Journal of Abnormal Psychology, 119, 502–512. Stewart, J., Bismark, A., Towers, D., Coan, J., & Allen, J. B. (2010). Resting frontal EEG asymmetry as an endophenotype for depression risk: Sex-specific patterns of frontal brain asymmetry. Journal of Abnormal Psychology, 119, 502–512.
go back to reference Sutton, S. K., Burnette, C., Mundy, P., Peyer, J., Vaughan, A., Sanders, C., et al. (2005). Resting cortical brain activity and social behavior in higher functioning children with Autism. Journal of Child Psychology and Psychiatry, 46, 211–222. PubMedCrossRef Sutton, S. K., Burnette, C., Mundy, P., Peyer, J., Vaughan, A., Sanders, C., et al. (2005). Resting cortical brain activity and social behavior in higher functioning children with Autism. Journal of Child Psychology and Psychiatry, 46, 211–222. PubMedCrossRef
go back to reference Sutton, S. K., & Davidson, R. J. (1997). Prefrontal brain asymmetry: A biological substrate of the behavioral approach and inhibition systems. Psychological Science, 8, 204–210. CrossRef Sutton, S. K., & Davidson, R. J. (1997). Prefrontal brain asymmetry: A biological substrate of the behavioral approach and inhibition systems. Psychological Science, 8, 204–210. CrossRef
go back to reference Tager-Flusberg, H. (2010). The origins of social impairments in autism spectrum disorder: Studies of infants at risk. Neural Networks, 23, 1072–1076. PubMedCentralPubMedCrossRef Tager-Flusberg, H. (2010). The origins of social impairments in autism spectrum disorder: Studies of infants at risk. Neural Networks, 23, 1072–1076. PubMedCentralPubMedCrossRef
go back to reference Tierney, A.L., Gabard-Durnam, L., Vogel-Farley, V., Tager-Flusberg, H., and Nelson, C.A. (2012). Developmental Trajectories of Resting EEG Power: An Endophenotype of Autism Spectrum Disorder. PLoS ONE, 7, doi: 10.​1371/​journal.​pone.​0039127. Tierney, A.L., Gabard-Durnam, L., Vogel-Farley, V., Tager-Flusberg, H., and Nelson, C.A. (2012). Developmental Trajectories of Resting EEG Power: An Endophenotype of Autism Spectrum Disorder. PLoS ONE, 7, doi: 10.​1371/​journal.​pone.​0039127.
go back to reference Turetsky, B., Calkins, M., Light, G., Olincy, A., Radant, A., & Swerdlow, N. (2007). Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. Schizophrenia Bulletin, 33, 69–94. PubMedCentralPubMedCrossRef Turetsky, B., Calkins, M., Light, G., Olincy, A., Radant, A., & Swerdlow, N. (2007). Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. Schizophrenia Bulletin, 33, 69–94. PubMedCentralPubMedCrossRef
go back to reference Viding, E., & Blakemore, S. J. (2007). Endophenotype approach to developmental psychopathology: Implications for autism research. Behavior Genetics, 37, 51–60. PubMedCrossRef Viding, E., & Blakemore, S. J. (2007). Endophenotype approach to developmental psychopathology: Implications for autism research. Behavior Genetics, 37, 51–60. PubMedCrossRef
go back to reference Yirmiya, N., Gamliel, I., Pilowsky, T., Feldman, R., Baron-Cohen, S., & Sigman, M. (2006). The development of siblings of children with autism at 4 and 14 months: Social engagement, communication, and cognition. Journal of Child Psychology and Psychiatry, 47, 511–523. PubMedCrossRef Yirmiya, N., Gamliel, I., Pilowsky, T., Feldman, R., Baron-Cohen, S., & Sigman, M. (2006). The development of siblings of children with autism at 4 and 14 months: Social engagement, communication, and cognition. Journal of Child Psychology and Psychiatry, 47, 511–523. PubMedCrossRef
go back to reference Zwaigenbaum, L., Bryson, S. E., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005). Behavioral manifestations of autism in the first year of life. International Journal of Developmental Neuroscience, 23, 143–152. PubMedCrossRef Zwaigenbaum, L., Bryson, S. E., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005). Behavioral manifestations of autism in the first year of life. International Journal of Developmental Neuroscience, 23, 143–152. PubMedCrossRef
go back to reference Zwaigenbaum, L., Thurm, A., Stone, W., Baranek, G., Bryson, S., Iverson, I., et al. (2007). Studying the emergence of autism spectrum disorders in high-risk infants: Methodological and practical issues. Journal of Autism and Developmental Disorders, 37, 466–480. PubMedCrossRef Zwaigenbaum, L., Thurm, A., Stone, W., Baranek, G., Bryson, S., Iverson, I., et al. (2007). Studying the emergence of autism spectrum disorders in high-risk infants: Methodological and practical issues. Journal of Autism and Developmental Disorders, 37, 466–480. PubMedCrossRef
Metagegevens
Titel
Alpha Asymmetry in Infants at Risk for Autism Spectrum Disorders
Auteurs
Laurel Gabard-Durnam
Adrienne L. Tierney
Vanessa Vogel-Farley
Helen Tager-Flusberg
Charles A. Nelson
Publicatiedatum
01-02-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1926-4