Gepubliceerd in:
01-02-2013
Alloantibody formation in patients with sickle cell disease
Auteurs:
J. Sins, W.G. van Riel, L. van Iersel, A.J. Willemze, Y.B. de Rijke, M.H. Cnossen, J.G. van der Bom, M. Peters, B. Biemond, K. Fijnvandraat
Gepubliceerd in:
Tijdschrift voor Kindergeneeskunde
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bijlage 1/2013
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Extract
Sickle cell disease (SCD) is a hereditary hemoglobinopathy, characterized by chronic anemia, recurrent painful episodes and irreversible organ damage. Transfusion of red blood cells is a common intervention to treat and prevent these complications. Patients with SCD have a high risk of alloantibody formation, leading to difficulties finding matching donors and an increased risk for transfusion reactions. The aim of this study is to evaluate the cumulative incidence of alloantibody formation in the Dutch SCD population, and to assess potential clinical determinants for alloimmunization. …