Adenosine administration in supraventricular tachycardia

The ECG during symptoms was strongly suggestive of typical atrial flutter. After adenosine administration, the heart rate slowed for a few seconds because of 3:1 atrioventricular (AV) conduction, but it then changed to 1:1 conduction response (Fig. 1). This was associated with haemodynamic instability, which required electrocardioversion. Although adenosine administration is usually innocuous, its potential harmful effects should not be underestimated. A careful analysis of the initial ECG could have foreseen this atypical response, as 1:1 AV conduction beats were observed [1]. These beats are indicators of a high sympathetic tone, which increased after adenosine administration, with the outcome described above [2]. This case shows the unusual but dangerous proarrhythmic effect of adenosine in patients with atrial flutter, after producing important sympathetic discharge and subsequent 1:1 AV conduction, as well as the presence of predictors in the ECG which discourage its administration [3].

Atrial flutter with 1:1 atrioventricular conduction after administration of adenosine.