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Journal of Autism and Developmental Disorders

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01-11-2008 | Original Paper

Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism

Auteurs: S. Jill James, Stepan Melnyk, Stefanie Jernigan, Amanda Hubanks, Shannon Rose, David W. Gaylor

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2008

Abstract

An integrated metabolic profile reflects the combined influence of genetic, epigenetic, and environmental factors that affect the candidate pathway of interest. Recent evidence suggests that some autistic children may have reduced detoxification capacity and may be under chronic oxidative stress. Based on reports of abnormal methionine and glutathione metabolism in autistic children, it was of interest to examine the same metabolic profile in the parents. The results indicated that parents share similar metabolic deficits in methylation capacity and glutathione-dependent antioxidant/detoxification capacity observed in many autistic children. Studies are underway to determine whether the abnormal profile in parents reflects linked genetic polymorphisms in these pathways or whether it simply reflects the chronic stress of coping with an autistic child.

vorige artikel Eye Direction, Not Movement Direction, Predicts Attention Shifts in Those with Autism Spectrum Disorders

volgende artikel Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism

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Titel: Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism
Auteurs: S. Jill James
Stepan Melnyk
Stefanie Jernigan
Amanda Hubanks
Shannon Rose
David W. Gaylor
Publicatiedatum: 01-11-2008
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-008-0591-5

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