Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 9/2017

06-07-2017 | Letter to the Editor

Abnormal sensory experiences, synaesthesia, and neurodevelopmental disorders

Auteur: Keith Fluegge

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2017

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Preliminary evidence suggests that sensory processing may be affected in autism spectrum disorders (ASD). The purpose of this letter is to highlight a few recent studies on the topic and tie the findings to a recently identified epidemiological risk factor for ASD, principally environmental exposure to the air pollutant, nitrous oxide (N2O). Animal studies have shown that trace levels of chronic N2O exposure are thought to involve dynorphin opioid peptide release and altered serotonergic neurotransmission, both of which may elicit profound changes in consciousness and induce synaesthesia experiences. Future research investigating abnormal sensory sensitivity in ASD should consider environmental exposure to N2O, which may induce the requisite neurochemical changes thought to underpin sensory dysregulation even at trace levels of exposure.
Literatuur
go back to reference Abdul-Kareem, H. S., Sharma, R. P., & Drown, D. B. (1991). Effects of repeated intermittent exposures to nitrous oxide on central neurotransmitters and hepatic methionine synthetase activity in CD-1 mice. Toxicology and Industrial Health, 7(1–2), 97–108. PubMed Abdul-Kareem, H. S., Sharma, R. P., & Drown, D. B. (1991). Effects of repeated intermittent exposures to nitrous oxide on central neurotransmitters and hepatic methionine synthetase activity in CD-1 mice. Toxicology and Industrial Health, 7(1–2), 97–108. PubMed
go back to reference Branda, E. M., Ramza, J. T., Cahill, F. J., Tseng, L. F., & Quock, R. M. (2000). Role of brain dynorphin in nitrous oxide antinociception in mice. Pharmacology, Biochemistry, and Behavior, 65, 217–221. CrossRefPubMed Branda, E. M., Ramza, J. T., Cahill, F. J., Tseng, L. F., & Quock, R. M. (2000). Role of brain dynorphin in nitrous oxide antinociception in mice. Pharmacology, Biochemistry, and Behavior, 65, 217–221. CrossRefPubMed
go back to reference Presti, M. F., & Lewis, M. H. (2005). Striatal opioid peptide content in an animal model of spontaneous stereotypic behavior. Behavioural Brain Research, 157(2), 363–368. CrossRefPubMed Presti, M. F., & Lewis, M. H. (2005). Striatal opioid peptide content in an animal model of spontaneous stereotypic behavior. Behavioural Brain Research, 157(2), 363–368. CrossRefPubMed
go back to reference Quock, R. M., Wetzel, P. J., Maillefer, R. H., Hodges, B. L., Curtis, B. A., & Czech, D. A. (1993). Benzodiazepine receptor-mediated behavioral effects of nitrous oxide in the rat social interaction test. Pharmacology, Biochemistry, and Behavior, 46, 161–165. CrossRefPubMed Quock, R. M., Wetzel, P. J., Maillefer, R. H., Hodges, B. L., Curtis, B. A., & Czech, D. A. (1993). Benzodiazepine receptor-mediated behavioral effects of nitrous oxide in the rat social interaction test. Pharmacology, Biochemistry, and Behavior, 46, 161–165. CrossRefPubMed
go back to reference Smeets, C. J., Jezierska, J., Watanabe, H., Duarri, A., Fokkens, M. R., Meijer, M. ,et al. (2015). Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23. Brain, 138(Pt 9), 2537–2552. doi: 10.​1093/​brain/​awv195. CrossRefPubMed Smeets, C. J., Jezierska, J., Watanabe, H., Duarri, A., Fokkens, M. R., Meijer, M. ,et al. (2015). Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23. Brain, 138(Pt 9), 2537–2552. doi: 10.​1093/​brain/​awv195. CrossRefPubMed
go back to reference Song, Y., & Hakoda, Y. (2015). Lack of global precedence and global-to-local interference without local processing deficit: A robust finding in children with attention-deficit/hyperactivity disorder under different visual angles of the Navon task. Neuropsychology, 29(6), 888–894. doi: 10.​1037/​neu0000213. CrossRefPubMed Song, Y., & Hakoda, Y. (2015). Lack of global precedence and global-to-local interference without local processing deficit: A robust finding in children with attention-deficit/hyperactivity disorder under different visual angles of the Navon task. Neuropsychology, 29(6), 888–894. doi: 10.​1037/​neu0000213. CrossRefPubMed
go back to reference Steiner, H., & Gerfen, C. R. (1998). Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior. Experimental Brain Research, 123(1–2), 60–76. CrossRefPubMed Steiner, H., & Gerfen, C. R. (1998). Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior. Experimental Brain Research, 123(1–2), 60–76. CrossRefPubMed
go back to reference Vanderschuren, L. J., Niesink, R. J., Spruijt, B. M., & Van Ree, J. M. (1995). Mu- and kappa-opioid receptor-mediated opioid effects on social play in juvenile rats. European Journal of Pharmacology, 276, 257–266. CrossRefPubMed Vanderschuren, L. J., Niesink, R. J., Spruijt, B. M., & Van Ree, J. M. (1995). Mu- and kappa-opioid receptor-mediated opioid effects on social play in juvenile rats. European Journal of Pharmacology, 276, 257–266. CrossRefPubMed
go back to reference Wigham, S., Rodgers, J., South, M., McConachie, H., & Freeston, M. (2015). The interplay between sensory processing abnormalities, intolerance of uncertainty, anxiety and restricted and repetitive behaviours in autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(4), 943–952. doi: 10.​1007/​s10803-014-2248-x. CrossRefPubMed Wigham, S., Rodgers, J., South, M., McConachie, H., & Freeston, M. (2015). The interplay between sensory processing abnormalities, intolerance of uncertainty, anxiety and restricted and repetitive behaviours in autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(4), 943–952. doi: 10.​1007/​s10803-014-2248-x. CrossRefPubMed
go back to reference Zhang, Z., Peterson, M., & Liu, H. (2013). Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses. Proceedings of the National Academy of Sciences of the United States of America, 110, 1095–1100. doi: 10.​1073/​pnas.​1212971110. CrossRefPubMed Zhang, Z., Peterson, M., & Liu, H. (2013). Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses. Proceedings of the National Academy of Sciences of the United States of America, 110, 1095–1100. doi: 10.​1073/​pnas.​1212971110. CrossRefPubMed
Metagegevens
Titel
Abnormal sensory experiences, synaesthesia, and neurodevelopmental disorders
Auteur
Keith Fluegge
Publicatiedatum
06-07-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3216-z