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Journal of Autism and Developmental Disorders

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01-08-2014 | Original Paper

A Twin Study of Heritable and Shared Environmental Contributions to Autism

Auteurs: Thomas W. Frazier, Lee Thompson, Eric A. Youngstrom, Paul Law, Antonio Y. Hardan, Charis Eng, Nathan Morris

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2014

Abstract

The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels (\( {\text{h}}_{g}^{2} = . 9 2{-} 1. 20 \)). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (.21, 95 % CI 0.15–0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements.

vorige artikel The Autism Diagnostic Observation Schedule, Module 4: Revised Algorithm and Standardized Severity Scores

volgende artikel Cognitive, Adaptive, and Psychosocial Differences Between High Ability Youth With and Without Autism Spectrum Disorder

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Titel: A Twin Study of Heritable and Shared Environmental Contributions to Autism
Auteurs: Thomas W. Frazier
Lee Thompson
Eric A. Youngstrom
Paul Law
Antonio Y. Hardan
Charis Eng
Nathan Morris
Publicatiedatum: 01-08-2014
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-014-2081-2

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