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A previous paper in this journal revealed substantial genetic overlap between the ADHD dimensions of hyperactivity-impulsivity and inattentiveness in a sample of 8-year old twins drawn from a UK-representative population sample. Four years later, when the twins were 12 years old, more than 5,500 pairs drawn from the same sample were rated again on the DSM-IV based Revised Conners’ Parent Rating Scale to assess symptoms on both ADHD dimensions. Heritabilities were high (around 70%) for both hyperactivity-impulsivity and inattentiveness and evidence for etiological sex differences was absent. The critical finding was a genetic correlation of 0.55, indicating that hyperactivity-impulsivity and inattentiveness are substantially influenced by the same genes but that the two dimensions also show large and significant unique genetic effects. These results in early adolescence confirm our findings in middle childhood, providing evidence for substantial genetic overlap as well as genetic heterogeneity of the ADHD dimensions. Future genetic studies should investigate the ADHD dimensions separately.
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Akaike, H. (1987). Factor analysis and AIC. Psychometrika, 52, 317–332. CrossRef
Association, A. P. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington: American Psychiatric Association.
Finkbeiner, C. (1979). Estimation for the multiple factor model when data are missing. Psychometrika, 44, 409–420. CrossRef
Levy, F., Hay, D. A., & Bennett, K. S. (2006). Genetics of attention deficit hyperactivity disorder: a current review and future prospects. International Journal of Disability, Development and Education, 53, 5–20. CrossRef
McLoughlin, G., Ronald, A., Kuntsi, J., Asherson, P., & Plomin, R. (2007). Genetic support for the dual nature of attention deficit hyperactivity disorder: substantial genetic overlap between the inattentive and hyperactive-impulsive components. Journal of Abnormal Child Psychology, 35, 999–1008. CrossRefPubMed
Nadder, T. S., Rutter, M., Silberg, J. L., Maes, H. H., & Eaves, L. J. (2002). Genetic effects on the variation and covariation of attention deficit-hyperactivity disorder (ADHD) and oppositional-defiant disorder/conduct disorder (Odd/CD) symptomatologies across informant and occasion of measurement. Psychological Medicine, 32, 39–53. CrossRefPubMed
Neale, M. C., Boker, S. M., Xie, G., & Mae, H. H. (2006a). Mx: Statistical modeling (7th ed.). VCU Box 900126, Richmond, VA 23298: Department of Psychiatry.
Neale, M. C., Roysamb, E., & Jacobson, K. (2006b). Multivariate genetic analysis of sex limitation and G x E interaction. Twin Research and Human Genetics, 9, 481–489.
Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2008). Behavioral genetics (5th ed.). New York: Worth Publishers.
Raftery, A. E. (1995). Bayesian model selection in social research. In P. V. Marsden (Ed.), Sociological methodology (pp. 111–163). Cambridge: Blackwell Publishers.
Rietveld, M. J., Hudziak, J. J., Bartels, M., Van Beijsterveldt, C. E., & Boomsma, D. I. (2003a). Heritability of attention problems in children: I. Cross-sectional results from a study of twins, age 3–12 years. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 117B, 102–113. CrossRef
Rietveld, M. J., Posthuma, D., Dolan, C. V., & Boomsma, D. I. (2003b). ADHD: sibling interaction or dominance: an evaluation of statistical power. Behavior Genetics, 33, 247–255. CrossRef
Todd, R. D., Rasmussen, E. R., Neuman, R. J., Reich, W., Hudziak, J. J., Bucholz, K. K., et al. (2001). Familiality and heritability of subtypes of attention deficit hyperactivity disorder in a population sample of adolescent female twins. The American Journal of Psychiatry, 158, 1891–1898. CrossRefPubMed
- A Twin Study of ADHD Symptoms in Early Adolescence: Hyperactivity-impulsivity and Inattentiveness Show Substantial Genetic Overlap but Also Genetic Specificity
Corina U. Greven
Frühling V. Rijsdijk
- Springer US