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Gepubliceerd in: Journal of Autism and Developmental Disorders 8/2019

08-05-2019 | Original Paper

A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder

Auteurs: Luke Bloy, Kobey Shwayder, Lisa Blaskey, Timothy P. L. Roberts, David Embick

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2019

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Abstract

This study introduces an objective neurophysiological marker of language ability, the integral of event-related desynchronization in the 5–20 Hz band during 0.2–1 seconds post auditory stimulation with interleaved word/non-word tokens. This measure correlates with clinical assessment of language function in both ASD and neurotypical pediatric populations. The measure does not appear related to general cognitive ability nor autism symptom severity (beyond degree of language impairment). We suggest that this oscillatory brain activity indexes lexical search and thus increases with increased search in the mental lexicon. While specificity for language impairment in ASD remains to be determined, such an objective index has potential utility in low functioning individuals with ASD and young children during language acquisition.
Woordenlijst
ERD
Event related desynchrony—task related decreases in oscillatory power relative to baseline
ERS
Event related synchrony—task related increases in oscillatory power relative to baseline
MEG
Magnetoencephalography
EEG
Electroencephalography
ASD
Autism spectrum disorder
TD
Typically developing
M50/M100
Prominent middle and late components of the auditory evoked field
Lexical
Relating to the words or vocabulary
Theta Band
Oscillatory activity between 4 and 6 Hz
Alpha Band
Oscillatory activity between 8 and 12 Hz
Beta Band
Oscillatory activity between 13 and 30 Hz
Gamma Band
Oscillatory activity above 30 Hz (typically below 100 Hz)
STG
Superior temporal gyrus
ADOS-CSS
Calibrated severity score derived from the autism diagnostic observation schedule
PRI
Perceptual reasoning index from the wechsler intelligence scale for children-IV
CELF-CLSS
Core language standard score from the clinical evaluation of language fundamentals
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Metagegevens
Titel
A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder
Auteurs
Luke Bloy
Kobey Shwayder
Lisa Blaskey
Timothy P. L. Roberts
David Embick
Publicatiedatum
08-05-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 8/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-019-04040-x

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