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12-11-2015 | Uitgave 2/2016

Journal of Behavioral Medicine 2/2016

A pilot study to improve adherence among MS patients who discontinue treatment against medical advice

Journal of Behavioral Medicine > Uitgave 2/2016
Jared Bruce, Amanda Bruce, Sharon Lynch, Lauren Strober, Sean O’Bryan, Deborah Sobotka, Joan Thelen, Abigail Ness, Morgan Glusman, Kathy Goggin, Andrea Bradley-Ewing, Delwyn Catley


Between 30 and 50 % of MS patients may prematurely discontinue disease modifying therapies. Little research has examined how to best talk with patients who have discontinued treatment against medical advice. The aim of this pilot study was to determine whether telephone counseling increases disease modifying therapy (DMT) re-initiation among nonadherent patients with multiple sclerosis (MS). Participants were eligible if they had relapsing-remitting disease, had stopped taking a DMT, and had no plan to re-initiate treatment despite a provider recommendation. Following a baseline assessment, 81 patients were randomly assigned to either five 20 min, weekly sessions of Motivational Interviewing/Cognitive Behavioral Therapy (MI-CBT) or Treatment as Usual (TAU) with brief education. At 10 weeks, patients initially assigned to TAU switched over to MI-CBT. Compared to patients in the TAU group, patients undergoing MI-CBT were significantly more likely to indicate they were re-initiating DMT (41.7 vs. 14.3 %). These significant results were replicated among patients crossing over from TAU to MI-CBT. Treatment satisfaction was high, with 97 % of participants reporting that they would recommend MI-CBT to other patients with MS. Results of this pilot study provide initial support for the use of MI-CBT among MS patients who have discontinued treatment against medical advice. NCT01925690.

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