Skip to main content
Top
Gepubliceerd in: Journal of Behavioral Medicine 2/2016

12-11-2015

A pilot study to improve adherence among MS patients who discontinue treatment against medical advice

Auteurs: Jared Bruce, Amanda Bruce, Sharon Lynch, Lauren Strober, Sean O’Bryan, Deborah Sobotka, Joan Thelen, Abigail Ness, Morgan Glusman, Kathy Goggin, Andrea Bradley-Ewing, Delwyn Catley

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 2/2016

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Between 30 and 50 % of MS patients may prematurely discontinue disease modifying therapies. Little research has examined how to best talk with patients who have discontinued treatment against medical advice. The aim of this pilot study was to determine whether telephone counseling increases disease modifying therapy (DMT) re-initiation among nonadherent patients with multiple sclerosis (MS). Participants were eligible if they had relapsing-remitting disease, had stopped taking a DMT, and had no plan to re-initiate treatment despite a provider recommendation. Following a baseline assessment, 81 patients were randomly assigned to either five 20 min, weekly sessions of Motivational Interviewing/Cognitive Behavioral Therapy (MI-CBT) or Treatment as Usual (TAU) with brief education. At 10 weeks, patients initially assigned to TAU switched over to MI-CBT. Compared to patients in the TAU group, patients undergoing MI-CBT were significantly more likely to indicate they were re-initiating DMT (41.7 vs. 14.3 %). These significant results were replicated among patients crossing over from TAU to MI-CBT. Treatment satisfaction was high, with 97 % of participants reporting that they would recommend MI-CBT to other patients with MS. Results of this pilot study provide initial support for the use of MI-CBT among MS patients who have discontinued treatment against medical advice.
Clinicaltrials.gov: NCT01925690.
Literatuur
go back to reference Amrhein, P. C., Miller, W. R., Yahne, C. E., Palmer, M., & Fulcher, L. (2003). Client commitment language during motivational interviewing predicts drug use outcomes. Journal of Consulting and Clinical Psychology, 71, 862–878.CrossRefPubMed Amrhein, P. C., Miller, W. R., Yahne, C. E., Palmer, M., & Fulcher, L. (2003). Client commitment language during motivational interviewing predicts drug use outcomes. Journal of Consulting and Clinical Psychology, 71, 862–878.CrossRefPubMed
go back to reference Berger, B. A., Liang, H., & Hudmon, K. S. (2005). Evaluation of software-based telephone counseling to enhance medication persistency among patients with multiple sclerosis. Journal of the American Pharmacists Association, 45, 466–472.CrossRefPubMed Berger, B. A., Liang, H., & Hudmon, K. S. (2005). Evaluation of software-based telephone counseling to enhance medication persistency among patients with multiple sclerosis. Journal of the American Pharmacists Association, 45, 466–472.CrossRefPubMed
go back to reference Bruce, J. M., Hancock, L. M., & Lynch, S. G. (2010). Objective adherence monitoring in multiple sclerosis: Initial validation and association with self-report. Multiple Sclerosis, 16, 112–120.CrossRefPubMed Bruce, J. M., Hancock, L. M., & Lynch, S. G. (2010). Objective adherence monitoring in multiple sclerosis: Initial validation and association with self-report. Multiple Sclerosis, 16, 112–120.CrossRefPubMed
go back to reference Castro-Borrero, W., Graves, D., Frohman, T. C., Flores, A. B., Hardeman, P., Logan, D., et al. (2012). Current and emerging therapies in multiple sclerosis: A systematic review. Therapeutic Advances in Neurological Disorders, 5, 205–220.CrossRefPubMedPubMedCentral Castro-Borrero, W., Graves, D., Frohman, T. C., Flores, A. B., Hardeman, P., Logan, D., et al. (2012). Current and emerging therapies in multiple sclerosis: A systematic review. Therapeutic Advances in Neurological Disorders, 5, 205–220.CrossRefPubMedPubMedCentral
go back to reference Ebers, G. C. (1998). Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. The Lancet, 352, 1498–504.CrossRef Ebers, G. C. (1998). Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. The Lancet, 352, 1498–504.CrossRef
go back to reference Freedman, M. S., Hughes, B., Mikol, D. D., Bennett, R., Cuffel, B., Divan, V., et al. (2008). Efficacy of disease-modifying therapies in relapsing remitting multiple sclerosis: A systematic comparison. European Neurology, 60, 1–11.CrossRefPubMed Freedman, M. S., Hughes, B., Mikol, D. D., Bennett, R., Cuffel, B., Divan, V., et al. (2008). Efficacy of disease-modifying therapies in relapsing remitting multiple sclerosis: A systematic comparison. European Neurology, 60, 1–11.CrossRefPubMed
go back to reference Gerkovich, M., Williams, K., Catley, D., & Goggin, K. (2008). Development and validation of a scale to measure motivation to adhere to HIV medication. Poster presented at the 3rd international conference on HIV treatment adherence. Gerkovich, M., Williams, K., Catley, D., & Goggin, K. (2008). Development and validation of a scale to measure motivation to adhere to HIV medication. Poster presented at the 3rd international conference on HIV treatment adherence.
go back to reference Goggin, K., Gerkovich, M., Williams, K., Banderas, J., Catley, D., Berkley-Patton, J., et al. (2013). A randomized controlled trial examining the efficacy of motivation counseling with observed therapy for anti-retroviral therapy adhrence. AIDS and Behavior, 17, 1992–2001.CrossRefPubMedPubMedCentral Goggin, K., Gerkovich, M., Williams, K., Banderas, J., Catley, D., Berkley-Patton, J., et al. (2013). A randomized controlled trial examining the efficacy of motivation counseling with observed therapy for anti-retroviral therapy adhrence. AIDS and Behavior, 17, 1992–2001.CrossRefPubMedPubMedCentral
go back to reference Halpern, R., Agarwal, S., Dembek, C., Borton, L., & Lopez-Bresnahan, M. (2011). Comparison of adherence and persistence among multiple sclerosis patients treated with disease-modifying therapies: A retrospective administrative claims analysis. Patient Prefer Adherence, 5, 73–84.CrossRefPubMedPubMedCentral Halpern, R., Agarwal, S., Dembek, C., Borton, L., & Lopez-Bresnahan, M. (2011). Comparison of adherence and persistence among multiple sclerosis patients treated with disease-modifying therapies: A retrospective administrative claims analysis. Patient Prefer Adherence, 5, 73–84.CrossRefPubMedPubMedCentral
go back to reference Heesen, C., Kasper, J., Segal, J., Kopke, S., & Muhlhauser, I. (2004). Decision role preferences, risk knowledge, and information interests in patients with multiple sclerosis. Multiple Sclerosis, 10, 643–650.CrossRefPubMed Heesen, C., Kasper, J., Segal, J., Kopke, S., & Muhlhauser, I. (2004). Decision role preferences, risk knowledge, and information interests in patients with multiple sclerosis. Multiple Sclerosis, 10, 643–650.CrossRefPubMed
go back to reference Heesen, C., Kiopke, S., Solari, A., Geiger, F., & Kasper, J. (2013). Patient autonomy in multiple sclerosis—Possible goals and assessment strategies. Journal of the Neurological Sciences, 331, 2–9.CrossRefPubMed Heesen, C., Kiopke, S., Solari, A., Geiger, F., & Kasper, J. (2013). Patient autonomy in multiple sclerosis—Possible goals and assessment strategies. Journal of the Neurological Sciences, 331, 2–9.CrossRefPubMed
go back to reference Hettema, J. E., & Hendricks, P. S. (2010). Motivational interviewing for smoking cessation: A meta-analytic review. Journal of Consulting and Clinical Psychology, 78, 868–884.CrossRefPubMed Hettema, J. E., & Hendricks, P. S. (2010). Motivational interviewing for smoking cessation: A meta-analytic review. Journal of Consulting and Clinical Psychology, 78, 868–884.CrossRefPubMed
go back to reference Kleinman, N. L., Beren, I. A., Rajagopalan, K., & Brook, R. A. (2010). Medication adherence with disease modifying treatments for multiple sclerosis among US employees. Journal of Medical Economics, 13, 633–640.CrossRefPubMed Kleinman, N. L., Beren, I. A., Rajagopalan, K., & Brook, R. A. (2010). Medication adherence with disease modifying treatments for multiple sclerosis among US employees. Journal of Medical Economics, 13, 633–640.CrossRefPubMed
go back to reference Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology, 33, 1444–1452.CrossRefPubMed Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology, 33, 1444–1452.CrossRefPubMed
go back to reference Miller, W., & Rollnick, S. (2013). Motivational interviewing: Helping people change (3rd ed.). New York: The Guilford Press. Miller, W., & Rollnick, S. (2013). Motivational interviewing: Helping people change (3rd ed.). New York: The Guilford Press.
go back to reference Mohr, D., Boudewyn, A. C., Likosky, W., Levine, E., & Goodkin, D. E. (2001). Injectable medication for the treatment of multiple sclerosis: The influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject. Annals of Behavioral Medicine, 23, 125–132.CrossRefPubMed Mohr, D., Boudewyn, A. C., Likosky, W., Levine, E., & Goodkin, D. E. (2001). Injectable medication for the treatment of multiple sclerosis: The influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject. Annals of Behavioral Medicine, 23, 125–132.CrossRefPubMed
go back to reference Mohr, D. C., Burke, H., Beckner, V., & Merluzzi, N. (2005). A preliminary report on a skills-based telephone-administered peer support programme for patients with multiple sclerosis. Multiple Sclerosis, 11, 222–226.CrossRefPubMed Mohr, D. C., Burke, H., Beckner, V., & Merluzzi, N. (2005). A preliminary report on a skills-based telephone-administered peer support programme for patients with multiple sclerosis. Multiple Sclerosis, 11, 222–226.CrossRefPubMed
go back to reference Mohr, D., Goodkin, D. E., Likosky, W., Gatto, N., Baumann, K., & Rudick, R. (1997). Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis. Archives of Neurology, 54, 531–533.CrossRefPubMed Mohr, D., Goodkin, D. E., Likosky, W., Gatto, N., Baumann, K., & Rudick, R. (1997). Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis. Archives of Neurology, 54, 531–533.CrossRefPubMed
go back to reference Parsons, J., Rosof, E., Punzalan, J., & Di Maria, L. (2005). Patient care and STDs. Aids, 19, 31–39. Parsons, J., Rosof, E., Punzalan, J., & Di Maria, L. (2005). Patient care and STDs. Aids, 19, 31–39.
go back to reference Pietrolongo, E., Giordano, A., Kleinefeld, M., Confalonieri, P., Lugaresi, A., & Tortorella, C. (2013). Decision-making in multiple sclerosis consultations in Italy: Third oberserve and patient assessments. PLoS ONE, 8, e60721.CrossRefPubMedPubMedCentral Pietrolongo, E., Giordano, A., Kleinefeld, M., Confalonieri, P., Lugaresi, A., & Tortorella, C. (2013). Decision-making in multiple sclerosis consultations in Italy: Third oberserve and patient assessments. PLoS ONE, 8, e60721.CrossRefPubMedPubMedCentral
go back to reference Pozzilli, C., Schweikert, B., Ecari, U., & Oentrich, W. (2011). Supportive strategies to improve adherence to IFN Beta-1b in multiple sclerosis—Results of the BPlus observational cohort study. Journal of Neurological Sciences, 307, 120–126.CrossRef Pozzilli, C., Schweikert, B., Ecari, U., & Oentrich, W. (2011). Supportive strategies to improve adherence to IFN Beta-1b in multiple sclerosis—Results of the BPlus observational cohort study. Journal of Neurological Sciences, 307, 120–126.CrossRef
go back to reference Reynolds, M. W., Stephen, R., Seaman, C., & Rajagopalan, K. (2010). Persistence and adherence to disease modifying drugs among patients with multiple sclerosis. Current Medical Research and Opinion, 26, 663–674.CrossRefPubMed Reynolds, M. W., Stephen, R., Seaman, C., & Rajagopalan, K. (2010). Persistence and adherence to disease modifying drugs among patients with multiple sclerosis. Current Medical Research and Opinion, 26, 663–674.CrossRefPubMed
go back to reference Simon, J. H., Jacobs, L. D., Campion, M., Wende, K., Simonian, N., Cookfair, D. L., et al. (1998). Magnetic resonance studies of intramuscular interferon beta-1a for relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group. Annals of Neurology, 43, 79–87.CrossRefPubMed Simon, J. H., Jacobs, L. D., Campion, M., Wende, K., Simonian, N., Cookfair, D. L., et al. (1998). Magnetic resonance studies of intramuscular interferon beta-1a for relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group. Annals of Neurology, 43, 79–87.CrossRefPubMed
go back to reference Tullman, M. J. (2013). Overview of the epidemiology, diagnosis, and disease progression associated with multiple sclerosis. The American Journal of Managed Care, 19, S15–S20.PubMed Tullman, M. J. (2013). Overview of the epidemiology, diagnosis, and disease progression associated with multiple sclerosis. The American Journal of Managed Care, 19, S15–S20.PubMed
go back to reference West, D., DiLillo, V., Bursac, Z., Gore, S., & Greene, P. (2007). Motivationa interviewing improves weight loss in women with type 2 diabetes. Diabetes Care, 30, 1081–1087.CrossRefPubMed West, D., DiLillo, V., Bursac, Z., Gore, S., & Greene, P. (2007). Motivationa interviewing improves weight loss in women with type 2 diabetes. Diabetes Care, 30, 1081–1087.CrossRefPubMed
go back to reference Wong, J., Gomes, T., Mamdani, M., Manno, M., & O’Conner, P. (2011). Adherence to multiple sclerosis disease-modifying therapies in Ontario is low. Canadian Journal of Neurological Sciences, 38, 429–433.CrossRefPubMed Wong, J., Gomes, T., Mamdani, M., Manno, M., & O’Conner, P. (2011). Adherence to multiple sclerosis disease-modifying therapies in Ontario is low. Canadian Journal of Neurological Sciences, 38, 429–433.CrossRefPubMed
Metagegevens
Titel
A pilot study to improve adherence among MS patients who discontinue treatment against medical advice
Auteurs
Jared Bruce
Amanda Bruce
Sharon Lynch
Lauren Strober
Sean O’Bryan
Deborah Sobotka
Joan Thelen
Abigail Ness
Morgan Glusman
Kathy Goggin
Andrea Bradley-Ewing
Delwyn Catley
Publicatiedatum
12-11-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 2/2016
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-015-9694-6

Andere artikelen Uitgave 2/2016

Journal of Behavioral Medicine 2/2016 Naar de uitgave