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Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2006

01-08-2006 | ORIGINAL PAPER

A New Neurobehavioral Model of Autism in Mice: Pre- and Postnatal Exposure to Sodium Valproate

Auteurs: George C. Wagner, Kenneth R. Reuhl, Michelle Cheh, Paulette McRae, Alycia K. Halladay

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2006

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Abstract

Autism symptoms, including impairments in language development, social interactions, and motor skills, have been difficult to model in rodents. Since children exposed in utero to sodium valproate (VPA) demonstrate behavioral and neuroanatomical abnormalities similar to those seen in autism, the neurodevelopmental effects of this antiepileptic agent were examined in mice following its pre- or postnatal administration. Exposed pups were evaluated in a battery of neurodevelopmental procedures designed to assess VPA-induced retardation (wherein a behavior fails to mature on schedule), regression (wherein a behavior does mature on time but then deteriorates), or intrusions (wherein normal behaviors are overshadowed by stereotypic or self-injurious behaviors). The resulting observations were interpreted in the context of this new strategy to model autism.
Literatuur
go back to reference Allen, S. M., & Davis, W. M. (1999). Relationship of dopamine to serotonin in the neonatal 6-OHDA rat model of Lesch-Nyhan syndrome. Behavioral Pharmacology, 10, 467–474.CrossRef Allen, S. M., & Davis, W. M. (1999). Relationship of dopamine to serotonin in the neonatal 6-OHDA rat model of Lesch-Nyhan syndrome. Behavioral Pharmacology, 10, 467–474.CrossRef
go back to reference Ardinger, H. H., Atkin, J. F., Blackston, D., Elsas, L. J., Clarren, S. K., Livingstone, S., Flannery, D. B., Pellock, J. M., Harrod, M. J., Lammer, E. J., Majewski, F., Schnizel, A., Toriello, H. V., & Hanson, J. W. (1988). Verification of the fetal valproate syndrome phenotype. American Journal Medical Genetics, 29, 171–185.CrossRef Ardinger, H. H., Atkin, J. F., Blackston, D., Elsas, L. J., Clarren, S. K., Livingstone, S., Flannery, D. B., Pellock, J. M., Harrod, M. J., Lammer, E. J., Majewski, F., Schnizel, A., Toriello, H. V., & Hanson, J. W. (1988). Verification of the fetal valproate syndrome phenotype. American Journal Medical Genetics, 29, 171–185.CrossRef
go back to reference Aylward, E. H., Minshew, N. J., Goldstein, G., Honeycutt, N. A., Augustine, A. M., Yates, K. O., Barta, P. E., & Pearlson, G. D. (1999). MRI volumes of amygdale and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology, 53, 2145–2150.PubMed Aylward, E. H., Minshew, N. J., Goldstein, G., Honeycutt, N. A., Augustine, A. M., Yates, K. O., Barta, P. E., & Pearlson, G. D. (1999). MRI volumes of amygdale and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology, 53, 2145–2150.PubMed
go back to reference Bachevalier, J., & Beauregard, M. (1993). Maturation of medial temporal lobe memory functions in rodents, monkeys, and humans. Hippocampus, 3, 191–202.PubMed Bachevalier, J., & Beauregard, M. (1993). Maturation of medial temporal lobe memory functions in rodents, monkeys, and humans. Hippocampus, 3, 191–202.PubMed
go back to reference Bauman, M., & Kemper, T. L. (1985). Histoanatomic observations of the brain in early infantile autism. Neurology, 35, 866–874.PubMed Bauman, M., & Kemper, T. L. (1985). Histoanatomic observations of the brain in early infantile autism. Neurology, 35, 866–874.PubMed
go back to reference Chapman, J. B., & Cutler, M. G. (1989). Effects of sodium valproate on development and social behaviour in the Mongolian gerbil. Neurotoxicolology & Teratology, 11, 193–198.CrossRef Chapman, J. B., & Cutler, M. G. (1989). Effects of sodium valproate on development and social behaviour in the Mongolian gerbil. Neurotoxicolology & Teratology, 11, 193–198.CrossRef
go back to reference Coldren, J. T., & Halloran, C. (2003). Spatial reversal as a measure of executive functioning in children with autism. Journal of Genetic Psychology, 164, 29–41.PubMedCrossRef Coldren, J. T., & Halloran, C. (2003). Spatial reversal as a measure of executive functioning in children with autism. Journal of Genetic Psychology, 164, 29–41.PubMedCrossRef
go back to reference Courchesne, E. (1997). Brainstem, cerebellar and limbic neuranatomical abnormalities in autism. Current Opinion in Neurobiology, 7, 269–278.CrossRefPubMed Courchesne, E. (1997). Brainstem, cerebellar and limbic neuranatomical abnormalities in autism. Current Opinion in Neurobiology, 7, 269–278.CrossRefPubMed
go back to reference Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R., Tigue, Z., Chisum, H. J., Moses, P., Pierce, K., Lord, C., Lincoln, A. J., Pizzo, S., Schreibman, L., Haas, R. H., Akshoofoff, N. A., & Courchesne, R. Y. (2001). Unusual brain growth patterns in early life in patients with autistic disorder: And MRI study. Neurology, 57, 245–254.PubMed Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R., Tigue, Z., Chisum, H. J., Moses, P., Pierce, K., Lord, C., Lincoln, A. J., Pizzo, S., Schreibman, L., Haas, R. H., Akshoofoff, N. A., & Courchesne, R. Y. (2001). Unusual brain growth patterns in early life in patients with autistic disorder: And MRI study. Neurology, 57, 245–254.PubMed
go back to reference Duva, C. A., Floresco, S. B., Wunderlich, G. R., Lao, T. L., Pinel, J. P., & Phillips, A. G. (1997). Disruption of spatial but not object-recognition memory by neurotoxic lesions of the dorsal hippocampus in rats. Behavioral Neuroscience, 111, 1184–1196.CrossRefPubMed Duva, C. A., Floresco, S. B., Wunderlich, G. R., Lao, T. L., Pinel, J. P., & Phillips, A. G. (1997). Disruption of spatial but not object-recognition memory by neurotoxic lesions of the dorsal hippocampus in rats. Behavioral Neuroscience, 111, 1184–1196.CrossRefPubMed
go back to reference Fatemi, S. H., Halt, A. R., Realmuto, G., Earle, J., Kist, D. A., Thuras, P., & Merz, A. (2002). Purkinje cell size is reduced in the cerebellum of patients with autism. Cellular and Molecular Neurobiology, 22, 171–175.CrossRefPubMed Fatemi, S. H., Halt, A. R., Realmuto, G., Earle, J., Kist, D. A., Thuras, P., & Merz, A. (2002). Purkinje cell size is reduced in the cerebellum of patients with autism. Cellular and Molecular Neurobiology, 22, 171–175.CrossRefPubMed
go back to reference Galini, R., Weiss, I., Cassel, J. C., & Kelche, C. (1998). Spatial memory, habituation and reactions to spatial and non-spatial changes in rats with selective lesions of the hippocampus, the entorhinal cortex or the subiculum. Behavioral Brain Research, 96, 1–12.CrossRef Galini, R., Weiss, I., Cassel, J. C., & Kelche, C. (1998). Spatial memory, habituation and reactions to spatial and non-spatial changes in rats with selective lesions of the hippocampus, the entorhinal cortex or the subiculum. Behavioral Brain Research, 96, 1–12.CrossRef
go back to reference Gallagher, M., & Holland, P. C. (1992). Preserved configural learning and spatial learning impairment in rats with hippocampal damage. Hippocampus, 2, 81–88.CrossRefPubMed Gallagher, M., & Holland, P. C. (1992). Preserved configural learning and spatial learning impairment in rats with hippocampal damage. Hippocampus, 2, 81–88.CrossRefPubMed
go back to reference Goldberg, M. C., Landa, R., Lasker, A., Cooper, L., & Zee, D. S. (2000). Evidence of normal cerebellar control of the vestibule-ocular reflex (VOR) in children with high-functioning autism. Journal of Autism and Developmental Disorders, 30, 519–524.CrossRefPubMed Goldberg, M. C., Landa, R., Lasker, A., Cooper, L., & Zee, D. S. (2000). Evidence of normal cerebellar control of the vestibule-ocular reflex (VOR) in children with high-functioning autism. Journal of Autism and Developmental Disorders, 30, 519–524.CrossRefPubMed
go back to reference Goldman, P. S. (1971). Functional development of the prefrontal cortex in early life and the problem of neuronal plasticity. Experimental Neurology, 32, 366–387.CrossRefPubMed Goldman, P. S. (1971). Functional development of the prefrontal cortex in early life and the problem of neuronal plasticity. Experimental Neurology, 32, 366–387.CrossRefPubMed
go back to reference Good, M., & Honey, R. C. (1997). Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning and spatial learning. Behavioral Neuroscience, 111, 487–493.CrossRefPubMed Good, M., & Honey, R. C. (1997). Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning and spatial learning. Behavioral Neuroscience, 111, 487–493.CrossRefPubMed
go back to reference Haberer, L. J., & Pollack, G. M. (1994). Disposition and protein binding of valproic acid in the developing rat. Drug Metabolism and Disposition, 22, 113–119.PubMed Haberer, L. J., & Pollack, G. M. (1994). Disposition and protein binding of valproic acid in the developing rat. Drug Metabolism and Disposition, 22, 113–119.PubMed
go back to reference Halladay, A. K., Kusnecov, A., Michna, L., Kita, T., Hara, C. & Wagner, G. C. (2003). Relationship between methamphetamine-induced dopamine release, hyperthermia, self-injurious behaviour and long-term dopamine depletion in BALB/c and C57BL/6 mice. Pharmacology & Toxicology, 93, 33–41.CrossRef Halladay, A. K., Kusnecov, A., Michna, L., Kita, T., Hara, C. & Wagner, G. C. (2003). Relationship between methamphetamine-induced dopamine release, hyperthermia, self-injurious behaviour and long-term dopamine depletion in BALB/c and C57BL/6 mice. Pharmacology & Toxicology, 93, 33–41.CrossRef
go back to reference Halladay, A. K., Wagner, G. C., Zhou, R., & Reuhl, K. R. (2004). Neurodevelopmental consequences of MeHg in an animal model of autism. Hawaii Neurotoxicology Conference. Halladay, A. K., Wagner, G. C., Zhou, R., & Reuhl, K. R. (2004). Neurodevelopmental consequences of MeHg in an animal model of autism. Hawaii Neurotoxicology Conference.
go back to reference Herbert, M. R., Ziegler, D. A., Deutsch, C. K., O’Brien, L. M., Lange, N., Bakardjiev, A., Hodgson, J., Adrien, K. T., Steele, S., Makris, N., Kennedy, D., Harris, G. J., & Caviness, V. S. (2003). Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain, 126, 1181–1192.CrossRef Herbert, M. R., Ziegler, D. A., Deutsch, C. K., O’Brien, L. M., Lange, N., Bakardjiev, A., Hodgson, J., Adrien, K. T., Steele, S., Makris, N., Kennedy, D., Harris, G. J., & Caviness, V. S. (2003). Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain, 126, 1181–1192.CrossRef
go back to reference Ingram, J. L., Peckharm, S. M., Tisdale, B., & Rodier, P. M. (2000). Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism. Neurotoxicology & Teratology, 22, 319–324.CrossRef Ingram, J. L., Peckharm, S. M., Tisdale, B., & Rodier, P. M. (2000). Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism. Neurotoxicology & Teratology, 22, 319–324.CrossRef
go back to reference Inouye, M. & Murakami, U. (1980). Temporal and spatial patterns of Purkinje cell formation in the mouse cerebellum. Journal of Comparative Neurology, 194(3), 499–503.CrossRefPubMed Inouye, M. & Murakami, U. (1980). Temporal and spatial patterns of Purkinje cell formation in the mouse cerebellum. Journal of Comparative Neurology, 194(3), 499–503.CrossRefPubMed
go back to reference Jinnah, H. A., Gage, F. H., & Friedmann, T. (1990). Animal models of Lesch-Nyhan Syndrome. Brain Research Bulletin, 25, 467–475.CrossRefPubMed Jinnah, H. A., Gage, F. H., & Friedmann, T. (1990). Animal models of Lesch-Nyhan Syndrome. Brain Research Bulletin, 25, 467–475.CrossRefPubMed
go back to reference Kates, W. R., Mostofsky, S., Zimmerman, A. W., Mazzocco, M. M., Landa, R., Warsofsky, I. S., Kaufmann, W. E., & Reiss, A. L. (1998). Neuroanatomical and neurocognitive differences in a pair of monozygotic twins discordant for strictly defined autism. Annals of Neurology, 43, 782–791.CrossRefPubMed Kates, W. R., Mostofsky, S., Zimmerman, A. W., Mazzocco, M. M., Landa, R., Warsofsky, I. S., Kaufmann, W. E., & Reiss, A. L. (1998). Neuroanatomical and neurocognitive differences in a pair of monozygotic twins discordant for strictly defined autism. Annals of Neurology, 43, 782–791.CrossRefPubMed
go back to reference Kelly, P. H., Sevoir, P. W., & Iversen, S. D. (1975). Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Research, 94, 507–522.CrossRefPubMed Kelly, P. H., Sevoir, P. W., & Iversen, S. D. (1975). Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Research, 94, 507–522.CrossRefPubMed
go back to reference Kimble, D. P., Kirkby, R. J., & Stein, D. G. (1966). Response perseveration interpretation of passive avoidance deficits in hippocampectomized rats. Journal of Comparative and Physiological Psychology, 61, 141–143.PubMedCrossRef Kimble, D. P., Kirkby, R. J., & Stein, D. G. (1966). Response perseveration interpretation of passive avoidance deficits in hippocampectomized rats. Journal of Comparative and Physiological Psychology, 61, 141–143.PubMedCrossRef
go back to reference Koch, S., Jager-Roman, E., Losche, G., Nau, H., Rating, D., & Helge, H. (1996). Antiepileptic drug treatment in pregnancy: Drug side effects in the neonate and neurological outcome. Acta Paediatricia, 84, 739–746.CrossRef Koch, S., Jager-Roman, E., Losche, G., Nau, H., Rating, D., & Helge, H. (1996). Antiepileptic drug treatment in pregnancy: Drug side effects in the neonate and neurological outcome. Acta Paediatricia, 84, 739–746.CrossRef
go back to reference Luna, B., Minshew, N. J., Garver, K. E., Lazar, N. A., Thulborn, K. R., Eddy, W. F., & Sweeney, J. A. (2002). Neocortical system abnormalities in autism. An fMRI study of spatial working memory. Neurology, 59, 834–840.PubMed Luna, B., Minshew, N. J., Garver, K. E., Lazar, N. A., Thulborn, K. R., Eddy, W. F., & Sweeney, J. A. (2002). Neocortical system abnormalities in autism. An fMRI study of spatial working memory. Neurology, 59, 834–840.PubMed
go back to reference Mawer, G., Clayton-Smith, J., Coyle, H., & Kini, U. (2002). Outcome of pregnancy in women attending an outpatient epilepsy clinic: Adverse features associated with higher doses of sodium valproate. Seizure, 692, 1–7. Mawer, G., Clayton-Smith, J., Coyle, H., & Kini, U. (2002). Outcome of pregnancy in women attending an outpatient epilepsy clinic: Adverse features associated with higher doses of sodium valproate. Seizure, 692, 1–7.
go back to reference Miller, E. A., Goldman, P. S., & Rosvold, H. E. (1973). Delayed recovery of function following orbital prefrontal lesions in infant monkeys. Science, 182, 304–306.PubMedCrossRef Miller, E. A., Goldman, P. S., & Rosvold, H. E. (1973). Delayed recovery of function following orbital prefrontal lesions in infant monkeys. Science, 182, 304–306.PubMedCrossRef
go back to reference Moore, S. J., Turnpenny, P., Quinn, A., Glover, S., Lloyd, D. J., Montgomery, T., & Dean, J. C. S. (2000). A clinical study of 57 children with fetal anticonvulsant syndromes. Journal of Medical Genetics, 37, 489–497.CrossRefPubMed Moore, S. J., Turnpenny, P., Quinn, A., Glover, S., Lloyd, D. J., Montgomery, T., & Dean, J. C. S. (2000). A clinical study of 57 children with fetal anticonvulsant syndromes. Journal of Medical Genetics, 37, 489–497.CrossRefPubMed
go back to reference Morris, R. G., Schenk, F., Tweedie, F., & Jarrard, L. E. (1990). Ibotenate lesions of hippocampus and/or subiculum: Dissociating components of allocentric spatial learning. European Journal of Neuroscience, 2, 1016–1028.CrossRefPubMed Morris, R. G., Schenk, F., Tweedie, F., & Jarrard, L. E. (1990). Ibotenate lesions of hippocampus and/or subiculum: Dissociating components of allocentric spatial learning. European Journal of Neuroscience, 2, 1016–1028.CrossRefPubMed
go back to reference Mueller, K., Saboda, S., Palmour, R., & Nyhan, W. L. (1982). Self-injurious behavior produced in rats by daily caffeine and continuous amphetamine. Pharmacology, Biochemistry & Behavior, 17, 613–617.CrossRef Mueller, K., Saboda, S., Palmour, R., & Nyhan, W. L. (1982). Self-injurious behavior produced in rats by daily caffeine and continuous amphetamine. Pharmacology, Biochemistry & Behavior, 17, 613–617.CrossRef
go back to reference Muller, R. A., Pierce, K., Ambrose, J. B., Allen, G., & Courchesne, E. (2001). Atypical patterns of cerebral motor activiation in autism: A functional magnetic resonance study. Biological Psychiatry, 49, 665–676.CrossRefPubMed Muller, R. A., Pierce, K., Ambrose, J. B., Allen, G., & Courchesne, E. (2001). Atypical patterns of cerebral motor activiation in autism: A functional magnetic resonance study. Biological Psychiatry, 49, 665–676.CrossRefPubMed
go back to reference Oliviera, M. G., Bueno, O. F., Pomarico, A. C., & Gugliano, E. B. (1997). Strategies used by hippocampal- and caudate-putamen-lesioned rats in a learning task. Neurobiology of Learning & Memory, 68, 32–41.CrossRef Oliviera, M. G., Bueno, O. F., Pomarico, A. C., & Gugliano, E. B. (1997). Strategies used by hippocampal- and caudate-putamen-lesioned rats in a learning task. Neurobiology of Learning & Memory, 68, 32–41.CrossRef
go back to reference Packard, M. G., & Teather, L. A. (1997). Double dissociation of hippocampal and dorsal-striatal memory systems by posttraining intracerebral injections of 2-amino-5-phosphonopentaonic acid. Behavioral Neuroscience, 111, 543–551.CrossRefPubMed Packard, M. G., & Teather, L. A. (1997). Double dissociation of hippocampal and dorsal-striatal memory systems by posttraining intracerebral injections of 2-amino-5-phosphonopentaonic acid. Behavioral Neuroscience, 111, 543–551.CrossRefPubMed
go back to reference Petrosini, L., Molinari, M., & Gremoli, T. (1990). Hermicerebellectomy and motor behavior in rats. I. Development of motor function after neonatal lesion. Experimental Brain Research, 82, 472–482.CrossRef Petrosini, L., Molinari, M., & Gremoli, T. (1990). Hermicerebellectomy and motor behavior in rats. I. Development of motor function after neonatal lesion. Experimental Brain Research, 82, 472–482.CrossRef
go back to reference Pierce, K., & Courchesne, E. (2001). Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism. Biological Psychiatry, 49, 655–664.CrossRefPubMed Pierce, K., & Courchesne, E. (2001). Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism. Biological Psychiatry, 49, 655–664.CrossRefPubMed
go back to reference Pierce, K., Muller, R.A., Ambrose, J., Allen, G., & Courchesne, E. (2001). Face processing occurs outside the fusiform ‘face area’ in autism: Evidence from functional MRI. Brain, 124, 2059–2073.CrossRefPubMed Pierce, K., Muller, R.A., Ambrose, J., Allen, G., & Courchesne, E. (2001). Face processing occurs outside the fusiform ‘face area’ in autism: Evidence from functional MRI. Brain, 124, 2059–2073.CrossRefPubMed
go back to reference Rice, D., & Barone, S. (2000). Critical periods of vulnerability for the developing nervous system: Evidence from human and animal models. Environmental Health Perspective, 108, 511–533.CrossRef Rice, D., & Barone, S. (2000). Critical periods of vulnerability for the developing nervous system: Evidence from human and animal models. Environmental Health Perspective, 108, 511–533.CrossRef
go back to reference Sandi, C., Rose, S. P., & Patterson, T. A. (1992). Unilateral hippocampal lesions prevent recall of a passive avoidance task in day-old chicks. Neuroscience Letters, 141, 255–258.CrossRefPubMed Sandi, C., Rose, S. P., & Patterson, T. A. (1992). Unilateral hippocampal lesions prevent recall of a passive avoidance task in day-old chicks. Neuroscience Letters, 141, 255–258.CrossRefPubMed
go back to reference Sears, L. L., Vest, C., Mohamed, S., Bailey, J., Ranson, B. J., & Piven, J. (1999). An MRI study of the basal ganglia in autism. Progress in Neuropsychopharmacology & Biological Psychiatry, 23, 613–624.CrossRef Sears, L. L., Vest, C., Mohamed, S., Bailey, J., Ranson, B. J., & Piven, J. (1999). An MRI study of the basal ganglia in autism. Progress in Neuropsychopharmacology & Biological Psychiatry, 23, 613–624.CrossRef
go back to reference Shishido, T., Watanabe, Y., Kato, K., Horikoshi, R., & Niwa, S. I. (2000). Effects of dopamine, NMDA, opiate, and serotonin-related agents on acute methamphetamine-induced self-injurious behavior in mice. Pharmacology, Biochemistry & Behavior, 66, 579–583.CrossRef Shishido, T., Watanabe, Y., Kato, K., Horikoshi, R., & Niwa, S. I. (2000). Effects of dopamine, NMDA, opiate, and serotonin-related agents on acute methamphetamine-induced self-injurious behavior in mice. Pharmacology, Biochemistry & Behavior, 66, 579–583.CrossRef
go back to reference Sobaniec-Lotoweska, M. E. (2001). Ultrastructure of purkinje cell perikara and their dendritic processes in the rat cerebellar cortex in experimental encephalopathy induced by chronic application of valproate. International Journal Experimental Pathology, 82, 337–348.CrossRef Sobaniec-Lotoweska, M. E. (2001). Ultrastructure of purkinje cell perikara and their dendritic processes in the rat cerebellar cortex in experimental encephalopathy induced by chronic application of valproate. International Journal Experimental Pathology, 82, 337–348.CrossRef
go back to reference Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., Maravilla, K. R., Giedd, J. N., Munson, J., Dawson, G., & Dager, S. R. (2002). Brain structural abnormalities in young children with autism spectrum disorder. Neurology, 59, 184–192.PubMed Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., Maravilla, K. R., Giedd, J. N., Munson, J., Dawson, G., & Dager, S. R. (2002). Brain structural abnormalities in young children with autism spectrum disorder. Neurology, 59, 184–192.PubMed
go back to reference Sweeten, T. L., Posey, D. J., Shekhar, A., & McDougle, C. J. (2002). The amygdale and related structures in the pathopysiology of autism. Pharmacology, Biochemistry & Behavior, 71, 449–455.CrossRef Sweeten, T. L., Posey, D. J., Shekhar, A., & McDougle, C. J. (2002). The amygdale and related structures in the pathopysiology of autism. Pharmacology, Biochemistry & Behavior, 71, 449–455.CrossRef
go back to reference Thullier, F., Lalonde, R., Mahler, P., Joyal, C. C., & Lestienne, F. (1996). Dorsal striatal lesions in rats. 2: Effects on spatial and non-spatial learning. Archives of Physiological Biochemistry, 104, 307–312.CrossRef Thullier, F., Lalonde, R., Mahler, P., Joyal, C. C., & Lestienne, F. (1996). Dorsal striatal lesions in rats. 2: Effects on spatial and non-spatial learning. Archives of Physiological Biochemistry, 104, 307–312.CrossRef
go back to reference Voorhees, C. V. (1986). Handbook of behavioral teratology. New York: Plenum Press. Voorhees, C. V. (1986). Handbook of behavioral teratology. New York: Plenum Press.
go back to reference Voorhees, C. V. (1987). Behavioral teratogenicity of valproic acid: Selective effects on behavior after prenatal exposure to rats. Psychopharmacology, 92, 173–179.PubMedCrossRef Voorhees, C. V. (1987). Behavioral teratogenicity of valproic acid: Selective effects on behavior after prenatal exposure to rats. Psychopharmacology, 92, 173–179.PubMedCrossRef
go back to reference Wallace, R. B., Kaplan, R., & Werboff, J. (1977). Hippocampus and behavioral maturation. International Journal of Neuroscience, 7, 185–200.PubMedCrossRef Wallace, R. B., Kaplan, R., & Werboff, J. (1977). Hippocampus and behavioral maturation. International Journal of Neuroscience, 7, 185–200.PubMedCrossRef
go back to reference Williams, G., King, J., Cunningham, M., Stephan, M., Kerr, B., & Hersh, J. H. (2001). Fetal valproate syndrome and autism: Additional evidence of an association. Developmental Medicine and Child Neurology, 43, 202–206.CrossRefPubMed Williams, G., King, J., Cunningham, M., Stephan, M., Kerr, B., & Hersh, J. H. (2001). Fetal valproate syndrome and autism: Additional evidence of an association. Developmental Medicine and Child Neurology, 43, 202–206.CrossRefPubMed
go back to reference Winocur, G. (1997). Hippocampal lesions alter conditioning to conditional and contextual stimuli. Behavioral Brain Research, 88, 219–229.CrossRef Winocur, G. (1997). Hippocampal lesions alter conditioning to conditional and contextual stimuli. Behavioral Brain Research, 88, 219–229.CrossRef
go back to reference Wolf, L. W., LaRegina, M. C., & Tolbert, D. L. (1996). A behavioral study of the development of hereditary cerebellar ataxia in the shaker rat mutant. Behavioral Brain Research, 75, 67–81.CrossRef Wolf, L. W., LaRegina, M. C., & Tolbert, D. L. (1996). A behavioral study of the development of hereditary cerebellar ataxia in the shaker rat mutant. Behavioral Brain Research, 75, 67–81.CrossRef
go back to reference Wu, Y., & Wang, L. (2002). The effects of antiepileptic drugs on spatial learning and hippocampal protein kinase C ( in immature rats. Brain Development, 24, 82–87.CrossRefPubMed Wu, Y., & Wang, L. (2002). The effects of antiepileptic drugs on spatial learning and hippocampal protein kinase C ( in immature rats. Brain Development, 24, 82–87.CrossRefPubMed
go back to reference Wong, W., Kumar, S., Rurak, D. W., Kwan, E., Abbott, F. S., & Riggs, K. W. (2000). Ontogeny of valproic acid disposition and metabolism: A developmental study in postnatal lambs and adult sheep. Drug Metabolism and Disposition, 28, 912–919.PubMed Wong, W., Kumar, S., Rurak, D. W., Kwan, E., Abbott, F. S., & Riggs, K. W. (2000). Ontogeny of valproic acid disposition and metabolism: A developmental study in postnatal lambs and adult sheep. Drug Metabolism and Disposition, 28, 912–919.PubMed
go back to reference Yu, S. Y., Sugiyama, Y., & Hanano, M. (1985). Changes in pharmacokinetics of valproic acid in guinea pigs from birth to maturity. Epilepsia, 26, 243–251.PubMedCrossRef Yu, S. Y., Sugiyama, Y., & Hanano, M. (1985). Changes in pharmacokinetics of valproic acid in guinea pigs from birth to maturity. Epilepsia, 26, 243–251.PubMedCrossRef
Metagegevens
Titel
A New Neurobehavioral Model of Autism in Mice: Pre- and Postnatal Exposure to Sodium Valproate
Auteurs
George C. Wagner
Kenneth R. Reuhl
Michelle Cheh
Paulette McRae
Alycia K. Halladay
Publicatiedatum
01-08-2006
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2006
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0117-y

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