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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-08-2006 | ORIGINAL PAPER

A New Neurobehavioral Model of Autism in Mice: Pre- and Postnatal Exposure to Sodium Valproate

Auteurs: George C. Wagner, Kenneth R. Reuhl, Michelle Cheh, Paulette McRae, Alycia K. Halladay

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2006

Abstract

Autism symptoms, including impairments in language development, social interactions, and motor skills, have been difficult to model in rodents. Since children exposed in utero to sodium valproate (VPA) demonstrate behavioral and neuroanatomical abnormalities similar to those seen in autism, the neurodevelopmental effects of this antiepileptic agent were examined in mice following its pre- or postnatal administration. Exposed pups were evaluated in a battery of neurodevelopmental procedures designed to assess VPA-induced retardation (wherein a behavior fails to mature on schedule), regression (wherein a behavior does mature on time but then deteriorates), or intrusions (wherein normal behaviors are overshadowed by stereotypic or self-injurious behaviors). The resulting observations were interpreted in the context of this new strategy to model autism.

vorige artikel Decoding of Emotion through Facial Expression, Prosody and Verbal Content in Children and Adolescents with Asperger’s Syndrome

volgende artikel Lexical Knowledge and Lexical Use in Autism

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Titel: A New Neurobehavioral Model of Autism in Mice: Pre- and Postnatal Exposure to Sodium Valproate
Auteurs: George C. Wagner
Kenneth R. Reuhl
Michelle Cheh
Paulette McRae
Alycia K. Halladay
Publicatiedatum: 01-08-2006
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2006
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-006-0117-y

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