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Research on Child and Adolescent Psychopathology

Gepubliceerd in:

01-08-2008

A Multivariate Genetic Analysis of Specific Phobia, Separation Anxiety and Social Phobia in Early Childhood

Auteurs: Thalia C. Eley, Fruhling V. Rijsdijk, Sean Perrin, Thomas G. O’Connor, Derek Bolton

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 6/2008

Abstract

Background

Comorbidity amongst anxiety disorders is very common in children as in adults and leads to considerable distress and impairment, yet is poorly understood. Multivariate genetic analyses can shed light on the origins of this comorbidity by revealing whether genetic or environmental risks for one disorder also influence another. We examined the genetic and environmental influences on the comorbidity between three common childhood anxiety disorders: Specific Phobia, Separation Anxiety and Social Phobia.

Methods

Using a two-phase design 4,662 twin-pairs were screened in the first phase and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria.

Results

Multivariate genetic analysis revealed significant shared environmental over-lap between Specific Phobia and Separation Anxiety and significant familial and non-shared environmental over-lap between Specific Phobia and Social Phobia.

Conclusions

Familial influences, especially shared environment, are central to the comorbidity between Specific Phobia and both Separation Anxiety and Social Phobia.

vorige artikel Working Memory Deficits in Boys with Attention-deficit/Hyperactivity Disorder (ADHD): The Contribution of Central Executive and Subsystem Processes

volgende artikel The Role of Family Functioning in Bipolar Disorder in Families

Angold, A., & Costello, E. J. (1993). Depressive comorbidity in children and adolescents: empirical, theoretical, and methodological issues. American Journal of Psychiatry, 150, 1779–1791.PubMed

Bogels, S. M., & Brechman-Toussaint, M. L. (2006). Family issues in child anxiety: Attachment, family functioning, parental rearing and beliefs. Clinical Psychology Review, 26, 834–856.PubMedCrossRef

Bolton, D., Eley, T. C., O’Connor, T. G., Perrin, S., Rabe-Hesketh, S., Rijsdijk, F. V., et al. (2006). Prevalence and genetic and environmental influences on anxiety disorders in 6-year-old twins. Psychological Medicine, 36, 335–344.PubMedCrossRef

Brown, T. A., & Barlow, D. H. (1992). Comorbidity among anxiety disorders: Implications for treatment and DSM-IV. Journal of Consulting and Clinical Psychology, 60, 835–844.PubMedCrossRef

Bruce, S. E., Yonkers, K. A., Otto, M. W., Eisen, J. L., Weisberg, R. B., Pagano, M., et al. (2005). Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, Social Phobia, and panic disorder: A 12-year prospective study. American Journal of Psychiatry, 162, 1179–1187.PubMedCrossRef

Chorpita, B. F., Brown, T. A., & Barlow, D. H. (1998). Perceived control as a mediator of family environment in etiological models of childhood anxiety. Behavior Therapy, 29, 457–476.CrossRef

Cobham, V. E., Dadds, M. R., & Spence, S. H. (1998). The role of parental anxiety in the treatment of childhood anxiety. Journal of Consulting & Clinical Psychology, 66, 893–905.CrossRef

Cohen, J. A. (1960). A coefficient of agreement for nominal scales. Educational and Psychological Measurement, 20, 37–46.CrossRef

Costello, E. J., Mustillo, S., Erkanli, A., Keeler, G., & Angold, A. (2003). Prevalence and development of psychiatric disorders in childhood and adolescence. Archives of General Psychiatry, 60, 837–844.PubMedCrossRef

Eaves, L. J., Silberg, J. L., Meyer, J. M., Maes, H. H., Simonoff, E., Pickles, A., et al. (1997). Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. Journal of Child Psychology and Psychiatry, 38, 965–980.PubMedCrossRef

Eley, T. C., Bolton, D., O’Connor, T. G., Perrin, S., Smith, P., & Plomin, R. (2003). A twin study of anxiety-related behaviours in pre-school children. Journal of Child Psychology and Psychiatry, 44, 945–960.PubMedCrossRef

Eley, T. C., & Stevenson, J. (1999). Using genetic analyses to clarify the distinction between depressive and anxious symptoms in children and adolescents. Journal of Abnormal Child Psychology, 27, 105–114.PubMedCrossRef

Essau, C. A., Conradt, J., & Petermann, F. (2000). Frequency, comorbidity, and psychosocial impairment of anxiety disorders in German adolescents. Journal of Anxiety Disorders, 14, 263–279.PubMedCrossRef

Feigon, S. A., Waldman, I. D., Levy, F., & Hay, D. A. (2001). Genetic and environmental influences on Separation Anxiety disorder symptoms and their moderation by age and sex. Behavior Genetics, 31, 403–411.PubMedCrossRef

Field, A. P., Ball, J. E., Kawycz, N. J., & Moore, H. (2007). Parent–child relationships and the verbal information pathway to fear in children: Two preliminary experiments. Behavioural and Cognitive Psychotherapy, 35, 473–486.CrossRef

Goodman, R. (1997). The strengths and difficulties questionnaire. Journal of Child Psychology & Psychiatry, 39, 581–586.CrossRef

Gregory, A. M., & Eley, T. C. (2007). Genetic influences on anxiety in children: What we’ve learned and where we’re heading. Clinical Child and Family Psychology Review, 10, 199–212.PubMedCrossRef

Kendler, K. S. (1996). Major depression and generalised anxiety disorder. Same genes, (partly)different environments—revisited. British Journal of Psychiatry Supplement, 68–75.

Kortlander, E., Kendall, P. C., & Panichelli-Mindel, S. M. (1997). Maternal expectations and attributions about coping in anxious children. Journal of Anxiety Disorders, 11, 297–315.PubMedCrossRef

Last, C. G., Strauss, C. C., & Francis, G. (1987). Comorbidity among childhood anxiety disorders. Journal of Nervous and Mental Disease, 175, 726–730.PubMedCrossRef

Lichtenstein, P., & Annas, P. (2000). Heritability and prevalence of specific fears and phobia in childhood. Journal of Child Psychology & Psychiatry, 41, 927–937.CrossRef

Martin, N., Boomsma, D. I., & Machin, G. (1997). A twin-pronged attack on complex trait. Nature Genetics, 17, 387–392.PubMedCrossRef

Maser, J. D., & Cloninger, C. R. (1990). Comorbidity of mood and anxiety disorders. Washington, DC: American Psychiatric Press.

Merikangas, K. R., & Angst, J. (1995). Comorbidity and Social Phobia: Evidence from clinical, epidemiologic, and genetic studies. European Archives of Psychiatry and Clinical Neuroscience, 244, 297–303.PubMedCrossRef

Neale, M. (1999). Mx: Statistical modeling (5th ed.). Richmond, VA 23298: Department of Psychiatry.

Neale, M., & Cardon, L. (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer Academic Publications.

Neale, M. C., & Miller, M. B. (1997). The use of likelihoodbased confidence intervals in genetic models. Behavior Genetics, 27, 113–120.PubMedCrossRef

Oest, L. G., & Treffers, P. D. A. (2001). Onset, course, and outcome for anxiety disorders in children. In W. K. Silverman, & P. D. A. Treffers (Eds.) Anxiety disorders in children and adoelscents: Research, assessment and intervention. Cambridge Child and Adolescent Psychiatry (pp. 293–312). New York: Cambridge University Press.

Ogliari, A., Citterio, A., Zanoni, A., Fagnani, C., Patriarca, V., Cirrincione, R., et al. (2006). Genetic and environmental influences on anxiety dimensions in Italian twins evaluated with the SCARED questionnaire. Journal of Anxiety Disorders, 20, 760–777.PubMedCrossRef

Otto, M. W., Pollack, M. H., Maki, K. M., Gould, R. A., Worthington III, J. J., Smoller, J. W., et al. (2001). Childhood history of anxiety disorders among adults with Social Phobia: Rates, correlates, and comparisons with patients with panic disorder. Depression and Anxiety, 14, 209–213.PubMedCrossRef

Perrin, S., & Last, C. G. (1995). Dealing with comorbidity. In A. R. Eisen, C. A. Kearney, & C. E. Schaefer (Eds.) Clinical handbook of anxiety disorders in children and adolescents (pp. 412–435). Lanham, MD, US: Jason Aronson.

Pollack, M. H. (2001). Comorbidity, neurobiology, and pharmacotherapy of social anxiety disorder. Journal of Clinical Psychiatry, 62(Suppl 12), 24–29.PubMed

Rachman, S. (2002). Fears born and bred: Non-associative fear acquisition? Behaviour Research and Therapy, 40, 121–126.PubMedCrossRef

Rohde, P., Lewinsohn, P., & Seeley, J. (1997). Comparability of telephone and face to face interviews in assessing axis I and II disorders. American Journal of Psychiatry, 154, 1593–1598.PubMed

Schneier, F. R., Johnson, J., Hornig, C. D., Liebowitz, M. R., & Weissman, M. M. (1992). Social Phobia. Comorbidity and morbidity in an epidemiologic sample. Archives of General Psychiatry, 49, 282–288.PubMed

Sham, P. C., Sterne, A., Purcell, S., Cherny, S. S., Webster, M., Rijsdijk, F. V., et al. (2000). GENESiS: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings. Twin Research, 3, 316–322.PubMedCrossRef

Silberg, J. L., Rutter, M., & Eaves, L. (2001). Genetic and environmental influences on the temporal association between earlier anxiety and later depression in girls. Biological Psychiatry, 49, 1040–1049 [erratum appears in Biol Psychiatry 2001 Sep 1;50(5):393.].PubMedCrossRef

Silverman, W. K., & Eisen, A. R. (1992). Age differences in the reliability of parental and child reports of child-anxious symptomatology using a structured interview. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 117–124.PubMedCrossRef

Silverman, W. K., & Nelles, W. B. (1998). The anxiety disorders interview schedule for children. Journal of American Academy of Child and Adolescent Psychiatry, 27, 772–778.CrossRef

Silverman, W. K., & Rabian, B. (1995). Test–retest reliability of the DSM-III-R childhood anxiety disorders symptoms using the Anxiety Disorders Interview Schedule for Children. Journal of Anxiety Disorders, 9, 139–150.CrossRef

Sobin, C., Weissman, M., Goldstein, R. B., & Adams, P. (1993). Diagnostic interviewing for family studies: Comparing telephone and face to face methods for diagnosis of lifetime psychiatric disorders. Psychiatric Genetics, 3, 227–233.CrossRef

Stevenson, J., Batten, N., & Cherner, M. (1992). Fears and fearfulness in children and adolescents: A genetic analysis of twin data. Journal of Child Psychology and Psychiatry, 33, 977–985.PubMedCrossRef

Topolski, T. D., Hewitt, J. K., Eaves, L. J., Silberg, J. L., Meyer, J. M., Rutter, M., et al. (1997). Genetic and environmental influences on child reports of manifest anxiety and symptoms of Separation Anxiety and overanxious disorders: A community-based twin study. Behavior Genetics, 27, 15–28.PubMedCrossRef

Trouton, A., Spinath, F. M., & Plomin, R. (2002). Twins Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behaviour problems in childhood. Twin Research, 5, 444–448.PubMedCrossRef

Titel: A Multivariate Genetic Analysis of Specific Phobia, Separation Anxiety and Social Phobia in Early Childhood
Auteurs: Thalia C. Eley
Fruhling V. Rijsdijk
Sean Perrin
Thomas G. O’Connor
Derek Bolton
Publicatiedatum: 01-08-2008
Uitgeverij: Springer US
Gepubliceerd in: Research on Child and Adolescent Psychopathology / Uitgave 6/2008
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI: https://doi.org/10.1007/s10802-008-9216-x

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Abstract

Background

Methods

Results

Conclusions

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