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01-08-2008 | Uitgave 6/2008

A Multivariate Genetic Analysis of Specific Phobia, Separation Anxiety and Social Phobia in Early Childhood

Tijdschrift:: Journal of Abnormal Child Psychology > Uitgave 6/2008

Auteurs:: Thalia C. Eley, Fruhling V. Rijsdijk, Sean Perrin, Thomas G. O’Connor, Derek Bolton

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Abstract

Background

Comorbidity amongst anxiety disorders is very common in children as in adults and leads to considerable distress and impairment, yet is poorly understood. Multivariate genetic analyses can shed light on the origins of this comorbidity by revealing whether genetic or environmental risks for one disorder also influence another. We examined the genetic and environmental influences on the comorbidity between three common childhood anxiety disorders: Specific Phobia, Separation Anxiety and Social Phobia.

Methods

Using a two-phase design 4,662 twin-pairs were screened in the first phase and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria.

Results

Multivariate genetic analysis revealed significant shared environmental over-lap between Specific Phobia and Separation Anxiety and significant familial and non-shared environmental over-lap between Specific Phobia and Social Phobia.

Conclusions

Familial influences, especially shared environment, are central to the comorbidity between Specific Phobia and both Separation Anxiety and Social Phobia.

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Titel: A Multivariate Genetic Analysis of Specific Phobia, Separation Anxiety and Social Phobia in Early Childhood
Auteurs:: Thalia C. Eley
Fruhling V. Rijsdijk
Sean Perrin
Thomas G. O’Connor
Derek Bolton
Publicatiedatum: 01-08-2008
DOI: https://doi.org/10.1007/s10802-008-9216-x
Uitgeverij: Springer US
Tijdschrift: Journal of Abnormal Child Psychology An official publication of the International Society for Research in Child and Adolescent Psychopathology
Uitgave 6/2008
Print ISSN: 0091-0627
Elektronisch ISSN: 1573-2835

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Abstract

Background

Methods

Results

Conclusions

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