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Gepubliceerd in: Journal of Autism and Developmental Disorders 9/2009

01-09-2009 | Original Paper

A Longitudinal Investigation of Psychotropic and Non-Psychotropic Medication Use Among Adolescents and Adults with Autism Spectrum Disorders

Auteurs: Anna J. Esbensen, Jan S. Greenberg, Marsha Mailick Seltzer, Michael G. Aman

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2009

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Abstract

Medication use was examined in 286 adolescents and adults with ASD over a 4.5 year period. A total of 70% were taking a psychotropic or non-psychotropic medication at the beginning of the study. Both the number of psychotropic and non-psychotropic medications taken, and the proportion of individuals taking these medications, increased significantly over the study period, with 81% taking at least one medication 4.5 years later. Our findings suggested a high likelihood of staying medicated over time. Thus, adolescents and adults with ASD are a highly and increasingly medicated population.
Literatuur
go back to reference Aman, M. G., & Langworthy, K. S. (2000). Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders. Journal of Autism and Developmental Disorders, 30, 451–459. doi:10.1023/A:1005559725475.PubMedCrossRef Aman, M. G., & Langworthy, K. S. (2000). Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders. Journal of Autism and Developmental Disorders, 30, 451–459. doi:10.​1023/​A:​1005559725475.PubMedCrossRef
go back to reference Aman, M. G., Van Bourgondien, M. E., Wolford, P. L., & Sarphare, G. (1995). Psychotropic and anticonvulsant drugs in subjects with autism: Prevalence and patterns of use. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 1672–1681. doi:10.1097/00004583-199512000-00018.PubMedCrossRef Aman, M. G., Van Bourgondien, M. E., Wolford, P. L., & Sarphare, G. (1995). Psychotropic and anticonvulsant drugs in subjects with autism: Prevalence and patterns of use. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 1672–1681. doi:10.​1097/​00004583-199512000-00018.PubMedCrossRef
go back to reference Aman, M. G., Lam, K. S. L., & Collier-Crespin, A. (2003). Prevalence and patterns of use of psychoactive medicines among individuals with autism in the autism society of Ohio. Journal of Autism and Developmental Disorders, 33, 527–534. doi:10.1023/A:1025883612879.PubMedCrossRef Aman, M. G., Lam, K. S. L., & Collier-Crespin, A. (2003). Prevalence and patterns of use of psychoactive medicines among individuals with autism in the autism society of Ohio. Journal of Autism and Developmental Disorders, 33, 527–534. doi:10.​1023/​A:​1025883612879.PubMedCrossRef
go back to reference Aman, M. G., Lam, K. S. L., & Van Bourgondien, M. E. (2005). Medication patterns in patients with autism: Temporal, regional, and demographic influences. Journal of Child and Adolescent Psychopharmacology, 15, 116–126. doi:10.1089/cap.2005.15.116.PubMedCrossRef Aman, M. G., Lam, K. S. L., & Van Bourgondien, M. E. (2005). Medication patterns in patients with autism: Temporal, regional, and demographic influences. Journal of Child and Adolescent Psychopharmacology, 15, 116–126. doi:10.​1089/​cap.​2005.​15.​116.PubMedCrossRef
go back to reference American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.
go back to reference Brereton, A. V., Tonge, B. J., & Einfeld, S. L. (2006). Psychopathology in children and adolescents with autism compared to young people with intellectual disability. Journal of Autism and Developmental Disorders, 36, 863–870. doi:10.1007/s10803-006-0125-y.PubMedCrossRef Brereton, A. V., Tonge, B. J., & Einfeld, S. L. (2006). Psychopathology in children and adolescents with autism compared to young people with intellectual disability. Journal of Autism and Developmental Disorders, 36, 863–870. doi:10.​1007/​s10803-006-0125-y.PubMedCrossRef
go back to reference Comer, R. J. (2002). PDR [physicians’ desk reference] drug guide for mental HEALTH professionals. Montvale, NJ: Thomson Medical Economics. Comer, R. J. (2002). PDR [physicians’ desk reference] drug guide for mental HEALTH professionals. Montvale, NJ: Thomson Medical Economics.
go back to reference Hanson, E., Kalish, L. A., Bunce, E., Curtis, C., McDaniel, S., Ware, J., et al. (2007). Use of complementary and alternative medicine among children diagnosed with autism spectrum disorder. Journal of Autism and Developmental Disorders, 37, 628–636. doi:10.1007/s10803-006-0192-0.PubMedCrossRef Hanson, E., Kalish, L. A., Bunce, E., Curtis, C., McDaniel, S., Ware, J., et al. (2007). Use of complementary and alternative medicine among children diagnosed with autism spectrum disorder. Journal of Autism and Developmental Disorders, 37, 628–636. doi:10.​1007/​s10803-006-0192-0.PubMedCrossRef
go back to reference King, B. H., Hollander, E., Sikich, L., McCracken, J. T., Scahill, L., Bregman, J. D., Donnelly, C. L., Anagnostou, E., Dukes, K., Sullivan, L., Hirtz, D., Wagner, A., Ritz, L., & STAART Psychopharmacology Network. (2009). Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior. Archives of General Psychiatry (in press). King, B. H., Hollander, E., Sikich, L., McCracken, J. T., Scahill, L., Bregman, J. D., Donnelly, C. L., Anagnostou, E., Dukes, K., Sullivan, L., Hirtz, D., Wagner, A., Ritz, L., & STAART Psychopharmacology Network. (2009). Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior. Archives of General Psychiatry (in press).
go back to reference Langworthy-Lam, K. S., Aman, M. G., & Van Bourgondien, M. E. (2002). Prevalence and patterns of use of psychoactive medicines in individuals with autism in the Autism Society of North Carolina. Journal of Child and Adolescent Psychopharmacology, 12, 311–321. doi:10.1089/104454602762599853.PubMedCrossRef Langworthy-Lam, K. S., Aman, M. G., & Van Bourgondien, M. E. (2002). Prevalence and patterns of use of psychoactive medicines in individuals with autism in the Autism Society of North Carolina. Journal of Child and Adolescent Psychopharmacology, 12, 311–321. doi:10.​1089/​1044546027625998​53.PubMedCrossRef
go back to reference Martin, A., Scahill, L., Klin, A., & Volkmar, F. R. (1999). Higher-functioning pervasive developmental disorders: Rates and patterns of psychotropic drug use. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 923–931. doi:10.1097/00004583-199907000-00024.PubMedCrossRef Martin, A., Scahill, L., Klin, A., & Volkmar, F. R. (1999). Higher-functioning pervasive developmental disorders: Rates and patterns of psychotropic drug use. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 923–931. doi:10.​1097/​00004583-199907000-00024.PubMedCrossRef
go back to reference Mawhood, L., Howlin, P., & Rutter, M. (2000). Autism and developmental receptive language disorder: A comparative follow-up in early adult life. I. Cognitive and language outcomes. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 41, 547–559. doi:10.1111/1469-7610.00642.PubMedCrossRef Mawhood, L., Howlin, P., & Rutter, M. (2000). Autism and developmental receptive language disorder: A comparative follow-up in early adult life. I. Cognitive and language outcomes. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 41, 547–559. doi:10.​1111/​1469-7610.​00642.PubMedCrossRef
go back to reference McDougle, C. J., Scahill, L., McCracken, J. T., Aman, M. G., Tierney, E., Arnold, L. E., et al. (2000). Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. Background and rationale for an initial controlled study of risperidone. Child and Adolescent Psychiatric Clinics of North America, 9, 201–224.PubMed McDougle, C. J., Scahill, L., McCracken, J. T., Aman, M. G., Tierney, E., Arnold, L. E., et al. (2000). Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. Background and rationale for an initial controlled study of risperidone. Child and Adolescent Psychiatric Clinics of North America, 9, 201–224.PubMed
go back to reference Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. (2002). Risperidone in children with autism and serious behavioral problems. The New England Journal of Medicine, 347, 314–321. doi:10.1056/NEJMoa013171.CrossRef Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. (2002). Risperidone in children with autism and serious behavioral problems. The New England Journal of Medicine, 347, 314–321. doi:10.​1056/​NEJMoa013171.CrossRef
go back to reference Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. (2005). Risperidone treatment of autistic disorder: Longer term benefits and blinded discontinuation after six months. The American Journal of Psychiatry, 162, 1361–1369. doi:10.1176/appi.ajp.162.7.1361.CrossRef Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. (2005). Risperidone treatment of autistic disorder: Longer term benefits and blinded discontinuation after six months. The American Journal of Psychiatry, 162, 1361–1369. doi:10.​1176/​appi.​ajp.​162.​7.​1361.CrossRef
go back to reference Scahill, L., Koenig, K., Carroll, D. H., & Pachler, M. (2007). Risperidone approved for the treatment of serious behavioral problems in children with autism. Psychopharmacology, 20, 188–190. Scahill, L., Koenig, K., Carroll, D. H., & Pachler, M. (2007). Risperidone approved for the treatment of serious behavioral problems in children with autism. Psychopharmacology, 20, 188–190.
go back to reference Shattuck, P. T., Seltzer, M. M., Greenberg, J. S., Orsmond, G. I., Bolt, D., Kring, S., et al. (2007). Change in autism symptoms and maladaptive behaviors in adolescents and adults with an autism spectrum disorder. Journal of Autism and Developmental Disorders, 37, 1735–1747. doi:10.1007/s10803-006-0307-7.PubMedCrossRef Shattuck, P. T., Seltzer, M. M., Greenberg, J. S., Orsmond, G. I., Bolt, D., Kring, S., et al. (2007). Change in autism symptoms and maladaptive behaviors in adolescents and adults with an autism spectrum disorder. Journal of Autism and Developmental Disorders, 37, 1735–1747. doi:10.​1007/​s10803-006-0307-7.PubMedCrossRef
go back to reference Tsakanikos, E., Costello, H., Holt, G., Sturmey, P., & Bouras, N. (2007). Behavior management problems as predictors of psychotropic medication and use of psychiatric services in adults with autism. Journal of Autism and Developmental Disorders, 37, 1080–1085. doi:10.1007/s10803-006-0248-1.PubMedCrossRef Tsakanikos, E., Costello, H., Holt, G., Sturmey, P., & Bouras, N. (2007). Behavior management problems as predictors of psychotropic medication and use of psychiatric services in adults with autism. Journal of Autism and Developmental Disorders, 37, 1080–1085. doi:10.​1007/​s10803-006-0248-1.PubMedCrossRef
Metagegevens
Titel
A Longitudinal Investigation of Psychotropic and Non-Psychotropic Medication Use Among Adolescents and Adults with Autism Spectrum Disorders
Auteurs
Anna J. Esbensen
Jan S. Greenberg
Marsha Mailick Seltzer
Michael G. Aman
Publicatiedatum
01-09-2009
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-009-0750-3

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