Lie-telling and secret-keeping are common behaviors during adolescence. Given the importance of honesty for building trust in positive relationships, the present study examined relations between lie-telling, secret-keeping, and relationship quality over time. Additionally, given the protective role of positive relationships in developing depression, the present study examined how lying to and keeping secrets from parents related to depressive symptoms over time. Children and adolescents (N = 1313; 8 to 15 years old at Time 1, Mage= 11.65, SD = 11.75; 50.04% male) reported on lying to parents, secret-keeping from parents, relationship quality with parents, and depressive symptoms at two time points one year apart. The results indicated that greater secret-keeping was bidirectionally associated with poorer parent-child relationship quality and greater depressive symptoms over time. Thus, keeping secrets from parents appears to be an important behavior to examine in the context of development between late childhood and adolescence.