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Gepubliceerd in: Child Psychiatry & Human Development 5/2020

12-07-2020 | Original Article

A Diagnostic Biomarker for Pediatric Generalized Anxiety Disorder Using the Error-Related Negativity

Auteurs: Gregory L. Hanna, Yanni Liu, Haley E. Rough, Mihir Surapaneni, Barbara S. Hanna, Paul D. Arnold, William J. Gehring

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 5/2020

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Abstract

The error-related negativity (ERN) is a negative deflection in the event-related potential following a mistake that is a putative biomarker of anxiety. The study assessed the ERN as a diagnostic biomarker using receiver operating characteristic (ROC) analyses in 96 cases with anxiety disorders (AD) and 96 matched healthy controls (HC) ages 8 to 18 years. Forty-one cases had generalized anxiety disorder (GAD); 55 cases had other anxiety disorders (OAD) without GAD. ERN amplitude was significantly increased in AD cases compared to HC. The area under the curve (AUC) in the ROC analysis was 0.64, indicating the ERN is an inadequate diagnostic test for AD altogether. The ERN was significantly increased in cases with either GAD or OAD compared to HC. The AUC in ROC analyses with GAD and OAD was 0.75 and 0.56, respectively, suggesting the ERN provides an adequate diagnostic test for GAD but not for OAD.
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Metagegevens
Titel
A Diagnostic Biomarker for Pediatric Generalized Anxiety Disorder Using the Error-Related Negativity
Auteurs
Gregory L. Hanna
Yanni Liu
Haley E. Rough
Mihir Surapaneni
Barbara S. Hanna
Paul D. Arnold
William J. Gehring
Publicatiedatum
12-07-2020
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 5/2020
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-020-01021-5

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