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Gepubliceerd in: Child Psychiatry & Human Development 5/2020

12-07-2020 | Original Article

A Diagnostic Biomarker for Pediatric Generalized Anxiety Disorder Using the Error-Related Negativity

Auteurs: Gregory L. Hanna, Yanni Liu, Haley E. Rough, Mihir Surapaneni, Barbara S. Hanna, Paul D. Arnold, William J. Gehring

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 5/2020

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Abstract

The error-related negativity (ERN) is a negative deflection in the event-related potential following a mistake that is a putative biomarker of anxiety. The study assessed the ERN as a diagnostic biomarker using receiver operating characteristic (ROC) analyses in 96 cases with anxiety disorders (AD) and 96 matched healthy controls (HC) ages 8 to 18 years. Forty-one cases had generalized anxiety disorder (GAD); 55 cases had other anxiety disorders (OAD) without GAD. ERN amplitude was significantly increased in AD cases compared to HC. The area under the curve (AUC) in the ROC analysis was 0.64, indicating the ERN is an inadequate diagnostic test for AD altogether. The ERN was significantly increased in cases with either GAD or OAD compared to HC. The AUC in ROC analyses with GAD and OAD was 0.75 and 0.56, respectively, suggesting the ERN provides an adequate diagnostic test for GAD but not for OAD.

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Literatuur
1.
go back to reference Merikangas KR, He JP, Burstein M, Swanson SA, Avenevoli S, Cui L, Benjet C, Georgiades K, Swendsen J (2010) Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication: Adolescent Supplement (NCS-A). J Am Acad Child Adolesc Psychiatry. 49(10):980–989 PubMedPubMedCentral Merikangas KR, He JP, Burstein M, Swanson SA, Avenevoli S, Cui L, Benjet C, Georgiades K, Swendsen J (2010) Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication: Adolescent Supplement (NCS-A). J Am Acad Child Adolesc Psychiatry. 49(10):980–989 PubMedPubMedCentral
2.
go back to reference Kessler RC, Avenevoli S, Costello EJ, Georgiades K, Green JG, Gruber MJ, He JP, Koretz D, Ka McLaughlin, Petukhova M, Sampson NA, Zaslavsky AM, Merikangas KR (2012) Prevalence, persistence, and sociodemographic correlates of DSM-IV disorders in the National Comorbidity Survey Replication Adolescent Supplement. Arch Gen Psychiatry 69(4):372–380 PubMed Kessler RC, Avenevoli S, Costello EJ, Georgiades K, Green JG, Gruber MJ, He JP, Koretz D, Ka McLaughlin, Petukhova M, Sampson NA, Zaslavsky AM, Merikangas KR (2012) Prevalence, persistence, and sociodemographic correlates of DSM-IV disorders in the National Comorbidity Survey Replication Adolescent Supplement. Arch Gen Psychiatry 69(4):372–380 PubMed
3.
go back to reference Wagner G, Zeiler M, Waldherr K, Philipp J, Truttmann S, Dur W, Treasure JL, Karwauntz AFK (2017) Mental health problems in Austrian adolescents: a nationwide, two-stage epidemiological study applying DSM-5 criteria. Eur Child Adolesc Psychiatry 26:1483–1499 PubMedPubMedCentral Wagner G, Zeiler M, Waldherr K, Philipp J, Truttmann S, Dur W, Treasure JL, Karwauntz AFK (2017) Mental health problems in Austrian adolescents: a nationwide, two-stage epidemiological study applying DSM-5 criteria. Eur Child Adolesc Psychiatry 26:1483–1499 PubMedPubMedCentral
4.
go back to reference Woodward LJ, Fergusson DM (2001) Life course outcomes of young people with anxiety disorders in adolescence. J Am Acad Child Adolesc Psychiatry 40(9):1086–1093 PubMed Woodward LJ, Fergusson DM (2001) Life course outcomes of young people with anxiety disorders in adolescence. J Am Acad Child Adolesc Psychiatry 40(9):1086–1093 PubMed
5.
go back to reference Boden JM, Fergusson DM, Horwood LJ (2007) Anxiety disorders and suicidal behaviours in adolescence and young adulthood: findings from a longitudinal study. Psychol Med 37(3):431–440 PubMed Boden JM, Fergusson DM, Horwood LJ (2007) Anxiety disorders and suicidal behaviours in adolescence and young adulthood: findings from a longitudinal study. Psychol Med 37(3):431–440 PubMed
6.
go back to reference Meyer A (2016) Developing psychiatric biomarkers: a review focusing on the error-related negativity as a biomarker for anxiety. Curr Treat Options Psych 3(4):356–364 Meyer A (2016) Developing psychiatric biomarkers: a review focusing on the error-related negativity as a biomarker for anxiety. Curr Treat Options Psych 3(4):356–364
7.
go back to reference Meyer A (2017) A biomarker of anxiety in children and adolescents: a review focusing on the error-related negativity (ERN) and anxiety across development. Dev Cogn Neurosci 27:58–68 PubMedPubMedCentral Meyer A (2017) A biomarker of anxiety in children and adolescents: a review focusing on the error-related negativity (ERN) and anxiety across development. Dev Cogn Neurosci 27:58–68 PubMedPubMedCentral
8.
go back to reference Pine DS, Leibenluft E (2015) Biomarkers with a mechanistic focus. JAMA Psychiatry 72(7):633–634 PubMed Pine DS, Leibenluft E (2015) Biomarkers with a mechanistic focus. JAMA Psychiatry 72(7):633–634 PubMed
9.
go back to reference Falkenstein M, Hohnsbein J, Hoormann J, Blanke L (1991) Effects of crossmodal divided attention on late ERP components. 2. Error processing in choice reaction tasks. Electroencephalogr Clin Neurophysiol 78(6):447–455 PubMed Falkenstein M, Hohnsbein J, Hoormann J, Blanke L (1991) Effects of crossmodal divided attention on late ERP components. 2. Error processing in choice reaction tasks. Electroencephalogr Clin Neurophysiol 78(6):447–455 PubMed
10.
go back to reference Gehring WJ, Goss B, Coles MGH, Meyer DE, Donchin E (1993) A neural system for error detection and compensation. Psychol Sci 4(6):385–390 Gehring WJ, Goss B, Coles MGH, Meyer DE, Donchin E (1993) A neural system for error detection and compensation. Psychol Sci 4(6):385–390
11.
go back to reference Gehring WJ, Liu Y, Orr JM, Carp J (2012) The error-related negativity (ERN/Ne). In: Luck SK, Kappenman E (eds) Oxford handbook of event-related potential components. Oxford University Press, New York, pp 231–291 Gehring WJ, Liu Y, Orr JM, Carp J (2012) The error-related negativity (ERN/Ne). In: Luck SK, Kappenman E (eds) Oxford handbook of event-related potential components. Oxford University Press, New York, pp 231–291
12.
go back to reference Meyer A, Bress JN, Proudfit GH (2014) Psychometric properties of the error-related negativity in children and adolescents. Psychophysiology 51(7):602–610 PubMed Meyer A, Bress JN, Proudfit GH (2014) Psychometric properties of the error-related negativity in children and adolescents. Psychophysiology 51(7):602–610 PubMed
13.
go back to reference Anokhin AP, Golosheykin S, Heath AC (2008) Heritability of frontal brain function related to action monitoring. Psychophysiology 45:524–534 PubMed Anokhin AP, Golosheykin S, Heath AC (2008) Heritability of frontal brain function related to action monitoring. Psychophysiology 45:524–534 PubMed
14.
go back to reference Tamnes CK, Walhovd KB, Torstveit M, Sells VT, Fjell AM (2013) Performance monitoring in children and adolescents: a review of developmental changes in the error-related negativity and brain maturation. Dev Cogn Neurosci 6:1–13 PubMedPubMedCentral Tamnes CK, Walhovd KB, Torstveit M, Sells VT, Fjell AM (2013) Performance monitoring in children and adolescents: a review of developmental changes in the error-related negativity and brain maturation. Dev Cogn Neurosci 6:1–13 PubMedPubMedCentral
15.
go back to reference Holroyd CB, Coles GH (2002) The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Psychol Rev 109(4):679–709 PubMed Holroyd CB, Coles GH (2002) The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Psychol Rev 109(4):679–709 PubMed
16.
go back to reference Bartholow BD, Pearson MA, Dickter CL, Sher KJ, Fabiani M, Gratton G (2005) Strategic control and medial frontal negativity: beyond errors and response conflict. Psychophysiology 42:33–42 PubMed Bartholow BD, Pearson MA, Dickter CL, Sher KJ, Fabiani M, Gratton G (2005) Strategic control and medial frontal negativity: beyond errors and response conflict. Psychophysiology 42:33–42 PubMed
17.
go back to reference Hajcak G, Moser JS, Yeung N, Simons RF (2005) On the ERN and the significance of errors. Psychophysiology 42(2):151–161 PubMed Hajcak G, Moser JS, Yeung N, Simons RF (2005) On the ERN and the significance of errors. Psychophysiology 42(2):151–161 PubMed
18.
go back to reference Weinberg A, Dieterich R, Riesel A (2015) Error-related brain activity in the age of RDoC: a review of the literature. Int J Psychophysiol 98(2):276–299 PubMed Weinberg A, Dieterich R, Riesel A (2015) Error-related brain activity in the age of RDoC: a review of the literature. Int J Psychophysiol 98(2):276–299 PubMed
19.
go back to reference Brooker RJ, Buss KA (2014) Toddler fearfulness is linked to individual differences in error-related negativity during preschool. Dev Neuropsychol 39(1):1–8 PubMedPubMedCentral Brooker RJ, Buss KA (2014) Toddler fearfulness is linked to individual differences in error-related negativity during preschool. Dev Neuropsychol 39(1):1–8 PubMedPubMedCentral
20.
go back to reference Meyer A, Weinberg A, Klein DN, Hajcak G (2012) The development of the error-related negativity (ERN) and its relationship with anxiety: evidence from 8 to 13 year-olds. Dev Cogn Neurosci 2(1):152–161 PubMed Meyer A, Weinberg A, Klein DN, Hajcak G (2012) The development of the error-related negativity (ERN) and its relationship with anxiety: evidence from 8 to 13 year-olds. Dev Cogn Neurosci 2(1):152–161 PubMed
21.
go back to reference Hajcak G, McDonald N, Simons RF (2003) Anxiety and error-related brain activity. Biol Psychol 64(1–2):77–90 PubMed Hajcak G, McDonald N, Simons RF (2003) Anxiety and error-related brain activity. Biol Psychol 64(1–2):77–90 PubMed
22.
go back to reference Agam Y, Hamlainen MS, Lee AKC, Dyckman KA, Friedman JS, Isom M, Makris N, Manoach DS (2011) Multimodal neuroimaging dissociate hemodynamic and electrophysiology correlates of error processing. Proc Natl Acad Sci 108:17556–17561 PubMed Agam Y, Hamlainen MS, Lee AKC, Dyckman KA, Friedman JS, Isom M, Makris N, Manoach DS (2011) Multimodal neuroimaging dissociate hemodynamic and electrophysiology correlates of error processing. Proc Natl Acad Sci 108:17556–17561 PubMed
23.
go back to reference Buzzell GA, Richards JE, White LK, Barker TV, Pine DS, Fox NA (2017) Development of the error-monitoring system from ages 9–35: unique insight provided by MRI-constrained source localization of EEG. NeuroImage 157:13–26 PubMedPubMedCentral Buzzell GA, Richards JE, White LK, Barker TV, Pine DS, Fox NA (2017) Development of the error-monitoring system from ages 9–35: unique insight provided by MRI-constrained source localization of EEG. NeuroImage 157:13–26 PubMedPubMedCentral
24.
go back to reference Luu P, Tucker DM, Makeig S (2004) Frontal midline theta and the error-related negativity; neurophysiological mechanisms of action regulation. Clin Neurophysiol 115:1821–1835 PubMed Luu P, Tucker DM, Makeig S (2004) Frontal midline theta and the error-related negativity; neurophysiological mechanisms of action regulation. Clin Neurophysiol 115:1821–1835 PubMed
25.
go back to reference Trujillo LT, Allen JJB (2007) Theta EEG dynamics of the error-related negativity. Clin Neurophysiology 118:645–668 Trujillo LT, Allen JJB (2007) Theta EEG dynamics of the error-related negativity. Clin Neurophysiology 118:645–668
26.
27.
go back to reference Cavanagh JF, Shackman AJ (2015) Frontal midline theta reflects anxiety and cognitive control: meta-analytic evidence. J Physiol Paris 109(1–3):3–15 PubMed Cavanagh JF, Shackman AJ (2015) Frontal midline theta reflects anxiety and cognitive control: meta-analytic evidence. J Physiol Paris 109(1–3):3–15 PubMed
28.
go back to reference Moser J, Moran T, Schroder H, Donnellan B, Yeung N (2013) On the relationship between anxiety and error monitoring: a meta-analysis and conceptual framework. Front Hum Neurosci 7:466 PubMedPubMedCentral Moser J, Moran T, Schroder H, Donnellan B, Yeung N (2013) On the relationship between anxiety and error monitoring: a meta-analysis and conceptual framework. Front Hum Neurosci 7:466 PubMedPubMedCentral
29.
go back to reference Moser JS (2017) The nature of the relationship between anxiety and the error-related negativity across development. Curr Behav Neurosci Rep 4(4):309–321 Moser JS (2017) The nature of the relationship between anxiety and the error-related negativity across development. Curr Behav Neurosci Rep 4(4):309–321
30.
go back to reference Ladouceur CD, Dahl RE, Birmaher B, Axelson DA, Ryan ND (2006) Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localization. J Child Psychol Psychiatry 47(10):1073–1082 PubMed Ladouceur CD, Dahl RE, Birmaher B, Axelson DA, Ryan ND (2006) Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localization. J Child Psychol Psychiatry 47(10):1073–1082 PubMed
31.
go back to reference Carrasco M, Hong C, Nienhuis JK, Harbin SM, Fitzgerald KD, Gehring WJ, Hanna GL (2013) Increased error-related brain activity in youth with obsessive-compulsive disorder and other anxiety disorders. Neurosci Lett 541:214–218 PubMedPubMedCentral Carrasco M, Hong C, Nienhuis JK, Harbin SM, Fitzgerald KD, Gehring WJ, Hanna GL (2013) Increased error-related brain activity in youth with obsessive-compulsive disorder and other anxiety disorders. Neurosci Lett 541:214–218 PubMedPubMedCentral
32.
go back to reference Meyer A, Hajcak G, Torpey DC, Kujawa A, Kim J, Bufferd S, Carlson G, Klein DN (2013) Increased error-related brain activity in six-year-old children with clinical anxiety. J Abnorm Child Psychol 41(8):1257–1266 PubMedPubMedCentral Meyer A, Hajcak G, Torpey DC, Kujawa A, Kim J, Bufferd S, Carlson G, Klein DN (2013) Increased error-related brain activity in six-year-old children with clinical anxiety. J Abnorm Child Psychol 41(8):1257–1266 PubMedPubMedCentral
33.
go back to reference Meyer A, Hajcak G, Glenn CR, Kujawa AJ, Klein DN (2017) Error-related brain activity is related to aversive potentiation of the startle response in children, but only the ERN is associated with anxiety disorders. Emotion 17(3):487 PubMed Meyer A, Hajcak G, Glenn CR, Kujawa AJ, Klein DN (2017) Error-related brain activity is related to aversive potentiation of the startle response in children, but only the ERN is associated with anxiety disorders. Emotion 17(3):487 PubMed
34.
go back to reference Kujawa A, Weinberg A, Bunford N, Fitzgerald KD, Hanna GL, Monk CS, Kennedy AE, Klumpp H, Hajcak G, Phan KL (2016) Error-related brain activity in youth and young adults before and after treatment for generalized or social anxiety disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 71:162–168 Kujawa A, Weinberg A, Bunford N, Fitzgerald KD, Hanna GL, Monk CS, Kennedy AE, Klumpp H, Hajcak G, Phan KL (2016) Error-related brain activity in youth and young adults before and after treatment for generalized or social anxiety disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 71:162–168
35.
go back to reference Ladouceur CD, Tan PZ, Sharma V, Bylsma LM, Silk JS, Siegle GJ, Forbes EE, McMakin DL, Dahl RE, Kendall PC, Mannarino A, Ryan ND (2018) Error-related brain activity in pediatric anxiety disorders remains elevated following individual therapy: a randomized clinical trial. J Child Psychol Psychiatry 59(11):1152–1161 PubMedPubMedCentral Ladouceur CD, Tan PZ, Sharma V, Bylsma LM, Silk JS, Siegle GJ, Forbes EE, McMakin DL, Dahl RE, Kendall PC, Mannarino A, Ryan ND (2018) Error-related brain activity in pediatric anxiety disorders remains elevated following individual therapy: a randomized clinical trial. J Child Psychol Psychiatry 59(11):1152–1161 PubMedPubMedCentral
36.
go back to reference McDermott JM, Perez-Edgar K, Henderson HA, Chronis-Tuscano A, Pine DS, Fox NA (2009) A history of childhood behavioral inhibition and enhanced response monitoring in adolescence are linked to clinical anxiety. Biol Psychiatry 65(5):445–448 PubMed McDermott JM, Perez-Edgar K, Henderson HA, Chronis-Tuscano A, Pine DS, Fox NA (2009) A history of childhood behavioral inhibition and enhanced response monitoring in adolescence are linked to clinical anxiety. Biol Psychiatry 65(5):445–448 PubMed
37.
go back to reference Meyer A, Hajcak G, Torpey-Newman DC, Kujawa A, Klein DN (2015) Enhanced error-related brain activity in children predicts the onset of anxiety disorders between the ages of 6 and 9. J Abnorm Child Psychol 124(2):266–274 Meyer A, Hajcak G, Torpey-Newman DC, Kujawa A, Klein DN (2015) Enhanced error-related brain activity in children predicts the onset of anxiety disorders between the ages of 6 and 9. J Abnorm Child Psychol 124(2):266–274
38.
go back to reference Meyer A, Nelson B, Perlman G, Klein DN, Kotov R (2018) A neural biomarker, the error-related negativity, predicts the first onset of generalized anxiety disorder in a large sample of adolescent females. J Child Psychol Psychiatry 59(11):1162–1170 PubMedPubMedCentral Meyer A, Nelson B, Perlman G, Klein DN, Kotov R (2018) A neural biomarker, the error-related negativity, predicts the first onset of generalized anxiety disorder in a large sample of adolescent females. J Child Psychol Psychiatry 59(11):1162–1170 PubMedPubMedCentral
39.
go back to reference Gullone E (2000) The development of normal fear: a century of research. Clin Psychol Rev 20:429–451 PubMed Gullone E (2000) The development of normal fear: a century of research. Clin Psychol Rev 20:429–451 PubMed
40.
go back to reference Hajcak G, Meyer A, Kotov R (2017) Psychometrics and the neuroscience of individual differences: internal consistency limits between-subjects effects. J Abnorm Psychol 126(6):823 PubMed Hajcak G, Meyer A, Kotov R (2017) Psychometrics and the neuroscience of individual differences: internal consistency limits between-subjects effects. J Abnorm Psychol 126(6):823 PubMed
41.
go back to reference Hosmer DW, Lemeshow S (2000) Applied logistic regression. Wiley, New York, NY Hosmer DW, Lemeshow S (2000) Applied logistic regression. Wiley, New York, NY
42.
go back to reference American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Arlington American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Arlington
43.
go back to reference Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36(7):980–988 PubMed Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36(7):980–988 PubMed
44.
go back to reference Hanna GL (2013) Schedule for obsessive-compulsive and other behavioral syndromes (SOCOBS). University of Michigan, Ann Arbor Hanna GL (2013) Schedule for obsessive-compulsive and other behavioral syndromes (SOCOBS). University of Michigan, Ann Arbor
45.
go back to reference Achenbach TM, Rescorla LA (2001) Manual for ASEBA school-age forms & profiles. University of Vermont, Research Center for Children, Youth, and Families, Burlington Achenbach TM, Rescorla LA (2001) Manual for ASEBA school-age forms & profiles. University of Vermont, Research Center for Children, Youth, and Families, Burlington
46.
go back to reference Eriksen BA, Eriksen CW (1974) Effects of noise letters upon the identification of a target letter in a non-search task. Percept Psychophys 16(1):143–149 Eriksen BA, Eriksen CW (1974) Effects of noise letters upon the identification of a target letter in a non-search task. Percept Psychophys 16(1):143–149
47.
go back to reference Hanna GL, Liu Y, Isaacs YE, Ayoub AM, Brosius A, Salander Z, Arnold PD, Gehring WJ (2018) Error-related brain activity in adolescents with obsessive-compulsive disorder and major depressive disorder. Depress Anxiety 35(8):752–760 PubMedPubMedCentral Hanna GL, Liu Y, Isaacs YE, Ayoub AM, Brosius A, Salander Z, Arnold PD, Gehring WJ (2018) Error-related brain activity in adolescents with obsessive-compulsive disorder and major depressive disorder. Depress Anxiety 35(8):752–760 PubMedPubMedCentral
48.
go back to reference Gratton G, Coles MGH, Donchin E (1983) A new method for offline removal of ocular artifact. Electroencephalogr Clin Neurophysiol 55(4):468–484 PubMed Gratton G, Coles MGH, Donchin E (1983) A new method for offline removal of ocular artifact. Electroencephalogr Clin Neurophysiol 55(4):468–484 PubMed
49.
go back to reference Meyer A, Lerner MD, De Los RA, Laird RD, Hajcak G (2017) Considering ERP difference scores as individual difference measures: issues with subtraction and alternative approaches. Psychophysiology 54(1):114–122 PubMed Meyer A, Lerner MD, De Los RA, Laird RD, Hajcak G (2017) Considering ERP difference scores as individual difference measures: issues with subtraction and alternative approaches. Psychophysiology 54(1):114–122 PubMed
50.
51.
go back to reference Youden WJ (1950) Index for rating diagnostic tests. Cancer 3(1):32–35 PubMed Youden WJ (1950) Index for rating diagnostic tests. Cancer 3(1):32–35 PubMed
52.
go back to reference Perkins NJ, Schisterman EF (2006) The inconsistency of “optimal” cutpoints obtained using two criteria based on the receiver operating characteristic curve. Am J Epidemiol 163(7):670–675 PubMedPubMedCentral Perkins NJ, Schisterman EF (2006) The inconsistency of “optimal” cutpoints obtained using two criteria based on the receiver operating characteristic curve. Am J Epidemiol 163(7):670–675 PubMedPubMedCentral
53.
go back to reference Hanna GL, Liu Y, Isaacs YE, Ayoub AM, Torres JJ, O'Hara NB, Gehring WJ (2016) Withdrawn/depressed behaviors and error-related brain activity in youth with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 55(10):906–913 PubMedPubMedCentral Hanna GL, Liu Y, Isaacs YE, Ayoub AM, Torres JJ, O'Hara NB, Gehring WJ (2016) Withdrawn/depressed behaviors and error-related brain activity in youth with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 55(10):906–913 PubMedPubMedCentral
54.
go back to reference Patriquin MA, Mathew SJ (2017) The neurobiological mechanisms of generalized anxiety disorder and chronic stress. Chronic Stress 1:1–10 Patriquin MA, Mathew SJ (2017) The neurobiological mechanisms of generalized anxiety disorder and chronic stress. Chronic Stress 1:1–10
55.
go back to reference Carrasco M, Harbin SM, Nienhuis JK, Fitzgerald KD, Gehring WJ, Hanna GL (2013) Increased error-related brain activity in youth with obsessive-compulsive disorder and unaffected siblings. Depress Anxiety 30(1):39–46 PubMed Carrasco M, Harbin SM, Nienhuis JK, Fitzgerald KD, Gehring WJ, Hanna GL (2013) Increased error-related brain activity in youth with obsessive-compulsive disorder and unaffected siblings. Depress Anxiety 30(1):39–46 PubMed
56.
go back to reference Patrick CJ, Hajcak G (2016) RDoC: translating promise into progress. Psychophysiology 53(3):415–424 PubMed Patrick CJ, Hajcak G (2016) RDoC: translating promise into progress. Psychophysiology 53(3):415–424 PubMed
57.
go back to reference Cavanagh JF, Meyer A, Hajcak G (2017) Error-specific cognitive control alterations in generalized anxiety disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 2(5):413–420 PubMedPubMedCentral Cavanagh JF, Meyer A, Hajcak G (2017) Error-specific cognitive control alterations in generalized anxiety disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 2(5):413–420 PubMedPubMedCentral
58.
go back to reference Canen MJ, Brooker RJ (2017) ERN, theta power, and risk for anxiety problems in preschoolers. Biol Psychol 123:103–110 PubMed Canen MJ, Brooker RJ (2017) ERN, theta power, and risk for anxiety problems in preschoolers. Biol Psychol 123:103–110 PubMed
59.
go back to reference Weinberg A, Klein DN, Hajcak G (2012) Increased error-related brain activity distinguishes generalized anxiety disorder with and without comorbid major depressive disorder. J Abnorm Psychol 121(4):885–896 PubMedPubMedCentral Weinberg A, Klein DN, Hajcak G (2012) Increased error-related brain activity distinguishes generalized anxiety disorder with and without comorbid major depressive disorder. J Abnorm Psychol 121(4):885–896 PubMedPubMedCentral
60.
go back to reference Weinberg A, Kotov R, Proudfit GH (2015) Neural indicators of error processing in generalized anxiety disorder, obsessive-compulsive disorder, and major depressive disorder. J Abnorm Psychol 124(1):172–185 PubMed Weinberg A, Kotov R, Proudfit GH (2015) Neural indicators of error processing in generalized anxiety disorder, obsessive-compulsive disorder, and major depressive disorder. J Abnorm Psychol 124(1):172–185 PubMed
Metagegevens
Titel
A Diagnostic Biomarker for Pediatric Generalized Anxiety Disorder Using the Error-Related Negativity
Auteurs
Gregory L. Hanna
Yanni Liu
Haley E. Rough
Mihir Surapaneni
Barbara S. Hanna
Paul D. Arnold
William J. Gehring
Publicatiedatum
12-07-2020
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 5/2020
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-020-01021-5