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Gepubliceerd in: Journal of Autism and Developmental Disorders 3/2006

01-04-2006

A Crossover Study of Risperidone in Children, Adolescents and Adults with Mental Retardation

Auteurs: Jessica A. Hellings, Jennifer R. Zarcone, R. Matthew Reese, Maria G. Valdovinos, Janet G. Marquis, Kandace K. Fleming, Stephen R. Schroeder

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2006

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Abstract

Risperidone has shown safety and efficacy for aggressive and destructive behaviors in short-term studies. This longer-duration study includes a broad sample. Forty subjects, aged 8–56 years (mean=22), all with mental retardation and 36 with autism spectrum disorders participated in this 22-week crossover study, with 24 weeks of open maintenance thereafter. Of 40 subjects, 23 (57.5%) responded fully (50% decrease in Aberrant Behavior Checklist-Community Irritability subscale score), while 35 subjects (87.5%) showed a 25% decrease. Gender, mood disorder, and antiseizure medications did not alter response. Increased appetite and weight gain were common. Low dose risperidone was effective for aggressive behavior in persons with MR. More long-term studies are needed, incorporating weight control interventions.
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Metagegevens
Titel
A Crossover Study of Risperidone in Children, Adolescents and Adults with Mental Retardation
Auteurs
Jessica A. Hellings
Jennifer R. Zarcone
R. Matthew Reese
Maria G. Valdovinos
Janet G. Marquis
Kandace K. Fleming
Stephen R. Schroeder
Publicatiedatum
01-04-2006
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2006
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0078-1