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Journal of Autism and Developmental Disorders

Gepubliceerd in:

21-04-2018 | Original Paper

A Comparison of Safety and Efficacy of Dexmedetomidine and Propofol in Children with Autism and Autism Spectrum Disorders Undergoing Magnetic Resonance Imaging

Auteurs: Kamal Abulebda, Ryan Louer, Riad Lutfi, Sheikh Sohail Ahmed

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2018

Abstract

Children with autism and autism spectrum disorders have a high incidence of neurologic comorbidities. Consequently, evaluation with magnetic resonance imaging (MRI) is deemed necessary. Sedating these patients poses several challenges. This retrospective study compared the efficacy and safety of dexmedetomidine to propofol in sedating autistic patients undergoing MRI. There were 56 patients in the dexmedetomidine group and 49 in the propofol group. All of the patients successfully completed the procedure. Recovery and discharge times were significantly lower in the propofol group, while the dexmedetomidine group maintained more stable hemodynamics. Both propofol and dexmedetomidine proved to be adequate and safe medications in the sedation of autistic children undergoing MRI.

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volgende artikel Largely Typical Electrophysiological Affective Responses to Special Interest Stimuli in Adolescents with Autism Spectrum Disorder

Ahmed, S. S., Unland, T., Slaven, J. E., Nitu, M. E., & Rigby, M. R. (2014). Successful use of intravenous dexmedetomidine for magnetic resonance imaging sedation in autistic children. Southern Medical Journal, 107(9), 559–564. https://doi.org/10.14423/SMJ.0000000000000160.CrossRefPubMed

Berkenbosch, J. W., Wankum, P. C., & Tobias, J. D. (2005). Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children. Pediatric Critical Care Medicine, 6(4), 435–439. https://doi.org/10.1097/01.PCC.0000163680.50087.93. quiz 440.CrossRefPubMed

Bhana, N., Goa, K. L., & McClellan, K. J. (2000). Dexmedetomidine. Drugs, 59(2), 263–268; discussion 269–270.CrossRefPubMed

Canitano, R., Luchetti, A., & Zappella, M. (2005). Epilepsy, electroencephalographic abnormalities, and regression in children with autism. Journal of Child Neurology, 20(1), 27–31. https://doi.org/10.1177/08830738050200010401.CrossRefPubMed

Chakrabarti, S., & Fombonne, E. (2005). Pervasive developmental disorders in preschool children: Confirmation of high prevalence. American Journal of Psychiatry, 162(6), 1133–1141. https://doi.org/10.1176/appi.ajp.162.6.1133.CrossRefPubMed

Chiaretti, A., Benini, F., Pierri, F., Vecchiato, K., Ronfani, L., Agosto, C., … Barbi, E. (2014). Safety and efficacy of propofol administered by paediatricians during procedural sedation in children. Acta Paediatrica, 103(2), 182–187. https://doi.org/10.1111/apa.12472.CrossRefPubMed

Coté, C. J., Wilson, S., PEDIATRICS, A. A. O., & DENTISTRY, A. A. O. P. (2016). Guidelines for monitoring and management of pediatric patients before, during, and after sedation for diagnostic and therapeutic procedures: Update 2016. Pediatrics. https://doi.org/10.1542/peds.2016-1212.

Coté, C. J., Wilson, S., Pediatrics, A. A. o., Dentistry, A. A. o., P., & Sedation, W. G. o. (2006). Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: An update. Pediatrics, 118(6), 2587–2602. https://doi.org/10.1542/peds.2006-2780.CrossRefPubMed

Cravero, J. P., Beach, M. L., Blike, G. T., Gallagher, S. M., Hertzog, J. H., & Consortium, P. S. R. (2009). The incidence and nature of adverse events during pediatric sedation/anesthesia with propofol for procedures outside the operating room: A report from the Pediatric Sedation Research Consortium. Anesthesia & Analgesia, 108(3), 795–804. https://doi.org/10.1213/ane.0b013e31818fc334.CrossRef

Deegan, R. J. (1992). Propofol: A review of the pharmacology and applications of an intravenous anesthetic agent. American Journal of the Medical Sciences, 304(1), 45–49.CrossRefPubMed

Diagnostic and Statistical Manual of Mental Disorders. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.

Disabilities, C. o. C. W., Pediatrics, S. o. D. B., Committee, B. F. S., & Committee, M. H. I. f. C. W. S. N. P. A. (2006). Identifying infants and young children with developmental disorders in the medical home: An algorithm for developmental surveillance and screening. Pediatrics, 118(1), 405–420. https://doi.org/10.1542/peds.2006-1231.CrossRef

Dyck, J. B., Maze, M., Haack, C., Vuorilehto, L., & Shafer, S. L. (1993). The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology, 78(5), 813–820.CrossRefPubMed

Gutstein, H. B., Johnson, K. L., Heard, M. B., & Gregory, G. A. (1992). Oral ketamine preanesthetic medication in children. Anesthesiology, 76(1), 28–33.CrossRefPubMed

Heard, C., Burrows, F., Johnson, K., Joshi, P., Houck, J., & Lerman, J. (2008). A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging. Anesthesia & Analgesia, 107(6), 1832–1839. https://doi.org/10.1213/ane.0b013e31818874ee.CrossRef

Hertzog, J. H., Dalton, H. J., Anderson, B. D., Shad, A. T., Gootenberg, J. E., & Hauser, G. J. (2000). Prospective evaluation of propofol anesthesia in the pediatric intensive care unit for elective oncology procedures in ambulatory and hospitalized children. Pediatrics, 106(4), 742–747.CrossRefPubMed

Kallio, A., Scheinin, M., Koulu, M., Ponkilainen, R., Ruskoaho, H., Viinamäki, O., & Scheinin, H. (1989). Effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on hemodynamic control mechanisms. Clinical Pharmacology & Therapeutics, 46(1), 33–42.CrossRef

Kamat, P. P., McCracken, C. E., Gillespie, S. E., Fortenberry, J. D., Stockwell, J. A., Cravero, J. P., & Hebbar, K. B. (2015). Pediatric critical care physician-administered procedural sedation using propofol: A report from the Pediatric Sedation Research Consortium Database. Pediatric Critical Care Medicine, 16(1), 11–20. https://doi.org/10.1097/PCC.0000000000000273.CrossRefPubMed

Kanto, J., & Gepts, E. (1989). Pharmacokinetic implications for the clinical use of propofol. Clinical Pharmacokinetics, 17(5), 308–326. https://doi.org/10.2165/00003088-198917050-00002.CrossRefPubMed

Koroglu, A., Demirbilek, S., Teksan, H., Sagir, O., But, A. K., & Ersoy, M. O. (2005). Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results. Br J Anaesth, 94(6), 821–824. https://doi.org/10.1093/bja/aei119.CrossRefPubMed

Koroglu, A., Teksan, H., Sagir, O., Yucel, A., Toprak, H. I., & Ersoy, O. M. (2006). A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging. Anesthesia & Analgesia, 103(1), 63–67. https://doi.org/10.1213/01.ANE.0000219592.82598.AA.CrossRef

Kotani, Y., Shimazawa, M., Yoshimura, S., Iwama, T., & Hara, H. (2008). The experimental and clinical pharmacology of propofol, an anesthetic agent with neuroprotective properties. CNS Neuroscience & Therapeutics, 14(2), 95–106. https://doi.org/10.1111/j.1527-3458.2008.00043.x.CrossRef

Krauss, B., & Green, S. M. (2006). Procedural sedation and analgesia in children. Lancet, 367(9512), 766–780. https://doi.org/10.1016/S0140-6736(06)68230-5.CrossRefPubMed

Lubisch, N., Roskos, R., & Berkenbosch, J. W. (2009). Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. Pediatric Neurology, 41(2), 88–94. https://doi.org/10.1016/j.pediatrneurol.2009.02.006.CrossRefPubMed

Mason, K. P., Sanborn, P., Zurakowski, D., Karian, V. E., Connor, L., Fontaine, P. J., & Burrows, P. E. (2004). Superiority of pentobarbital versus chloral hydrate for sedation in infants during imaging. Radiology, 230(2), 537–542. https://doi.org/10.1148/radiol.2302030107.CrossRefPubMed

Mason, K. P., Zgleszewski, S. E., Dearden, J. L., Dumont, R. S., Pirich, M. A., Stark, C. D., … Zurakowski, D. (2006). Dexmedetomidine for pediatric sedation for computed tomography imaging studies. Anesthesia & Analgesia, 103(1), 57–62. https://doi.org/10.1213/01.ane.0000216293.16613.15.CrossRef

Mehta, U. C., Patel, I., & Castello, F. V. (2004). EEG sedation for children with autism. Journal of Developmental & Behavioral Pediatrics, 25(2), 102–104.CrossRef

Myers, S. M., Johnson, C. P., & Disabilities, A. A. o. P. C. o. C. W. (2007). Management of children with autism spectrum disorders. Pediatrics, 120(5), 1162–1182. https://doi.org/10.1542/peds.2007-2362.CrossRefPubMed

Rainey, L., & van der Walt, J. H. (1998). The anaesthetic management of autistic children. Anaesth Intensive Care, 26(6), 682–686.PubMed

Seid, M., Sherman, M., & Seid, A. B. (1997). Perioperative psychosocial interventions for autistic children undergoing ENT surgery. International Journal of Pediatric Otorhinolaryngology, 40(2–3), 107–113.CrossRefPubMed

Shelly, M. P. (2001). Dexmedetomidine: a real innovation or more of the same? British Journal of Anaesthesia, 87(5), 677–678.CrossRefPubMed

Sulton, C., McCracken, C., Simon, H. K., Hebbar, K., Reynolds, J., Cravero, J., … Kamat, P. (2016). Pediatric procedural sedation using dexmedetomidine: A Report From the Pediatric Sedation Research Consortium. Hospital Pediatrics, 6(9), 536–544. https://doi.org/10.1542/hpeds.2015-0280.CrossRefPubMed

Tramèr, M. R., Moore, R. A., & McQuay, H. J. (1997). Propofol and bradycardia: causation, frequency and severity. British Journal of Anaesthesia, 78(6), 642–651.CrossRefPubMed

Vardi, A., Salem, Y., Padeh, S., Paret, G., & Barzilay, Z. (2002). Is propofol safe for procedural sedation in children? A prospective evaluation of propofol versus ketamine in pediatric critical care. Critical Care Medicine, 30(6), 1231–1236.CrossRefPubMed

Weerink, M. A. S., Struys, M. M. R. F., Hannivoort, L. N., Barends, C. R. M., Absalom, A. R., & Colin, P. (2017). Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine. Clinical Pharmacokinectics, 56(8), 893–913. https://doi.org/10.1007/s40262-017-0507-7.CrossRef

Titel: A Comparison of Safety and Efficacy of Dexmedetomidine and Propofol in Children with Autism and Autism Spectrum Disorders Undergoing Magnetic Resonance Imaging
Auteurs: Kamal Abulebda
Ryan Louer
Riad Lutfi
Sheikh Sohail Ahmed
Publicatiedatum: 21-04-2018
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-018-3582-1

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