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06-06-2019 | Original Paper

A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism

Journal of Autism and Developmental Disorders
Bi Lian Li, Vivian Man-ying Yuen, Na Zhang, Huan Huan Zhang, Jun Xiang Huang, Si Yuan Yang, Jeffery W. Miller, Xing Rong Song
Belangrijke opmerkingen
The results of this study have been presented as oral presentation at the Lancet-Chinese Academy Medical Sciences Health Summit in December 2017 and we have won the best abstract award in this meeting.
Bi Lian Li and Vivian Man-ying Yuen contributed equally to this study.

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Children with autism often need sedation for diagnostic procedures and they are often difficult to sedate. This prospective randomized double-blind control trial evaluates the efficacy and safety using intranasal dexmedetomidine with and without buccal midazolam for sedation in children with autism undergoing computerized tomography and/or auditory brainstem response test. The primary outcome is the proportion of children attaining satisfactory sedation. One hundred and thirty-six children received intranasal dexmedetomidine and 139 received intranasal dexmedetomidine with buccal midazolam for sedation. Combination of intranasal dexmedetomidine and buccal midazolam was associated with higher sedation success when compared to intranasal dexmedetomidine. Since intranasal and buccal sedatives required little cooperation this could be especially useful technique for children with autism or other behavioral conditions.

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