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Journal of Autism and Developmental Disorders

Gepubliceerd in:

06-06-2019 | Original Paper

A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism

Auteurs: Bi Lian Li, Vivian Man-ying Yuen, Na Zhang, Huan Huan Zhang, Jun Xiang Huang, Si Yuan Yang, Jeffery W. Miller, Xing Rong Song

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2019

Abstract

Children with autism often need sedation for diagnostic procedures and they are often difficult to sedate. This prospective randomized double-blind control trial evaluates the efficacy and safety using intranasal dexmedetomidine with and without buccal midazolam for sedation in children with autism undergoing computerized tomography and/or auditory brainstem response test. The primary outcome is the proportion of children attaining satisfactory sedation. One hundred and thirty-six children received intranasal dexmedetomidine and 139 received intranasal dexmedetomidine with buccal midazolam for sedation. Combination of intranasal dexmedetomidine and buccal midazolam was associated with higher sedation success when compared to intranasal dexmedetomidine. Since intranasal and buccal sedatives required little cooperation this could be especially useful technique for children with autism or other behavioral conditions.

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Titel: A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism
Auteurs: Bi Lian Li
Vivian Man-ying Yuen
Na Zhang
Huan Huan Zhang
Jun Xiang Huang
Si Yuan Yang
Jeffery W. Miller
Xing Rong Song
Publicatiedatum: 06-06-2019
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-019-04095-w

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