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01-05-2007 | Original Paper | Uitgave 5/2007

[³H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 5/2007

Auteurs:: Jeffrey T. Guptill, Anne B. Booker, Terrell T. Gibbs, Thomas L. Kemper, Margaret L. Bauman, Gene J. Blatt

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Abstract

Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [³H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B _max) or altered affinity (K _d) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B _max indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K _d values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABA_A receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry.

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Titel: [3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study
Auteurs:: Jeffrey T. Guptill
Anne B. Booker
Terrell T. Gibbs
Thomas L. Kemper
Margaret L. Bauman
Gene J. Blatt
Publicatiedatum: 01-05-2007
DOI: https://doi.org/10.1007/s10803-006-0226-7
Uitgeverij: Kluwer Academic Publishers-Plenum Publishers
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 5/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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