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06-05-2021 | Original Article

Proof of Concept Study of an Oral Orthotic in Reducing Tic Severity in Tourette Syndrome

Auteurs: Shannon M. Bennett, Jeffrey S. Hindin, Justin Mohatt, Christopher Bauer, Jennifer Schild, Avital Falk, Matthew Specht, Douglas Woods, John Walkup

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 5/2022

Abstract

The use of an oral orthotic, called an occlusal splint, has gained recognition for the potential to reduce the frequency of tics for individuals with Persistent Tic Disorders. The purpose of this study was to assess the feasibility of a fully blinded, randomized controlled trial (RCT) to assess the safety, tolerability and initial efficacy of the oral orthotic in youth with chronic tics. Thirteen youth were randomly assigned to wear an active or sham orthotic in a two week double-blind RCT, with a 4–6 week unblinded follow up period. A statistically significant difference was found for change in tic severity between participants wearing the active and sham orthotic. However, this difference was not replicated during the follow up period. The oral orthotic is a promising intervention for the reduction of tics in youth with Tourette’s Syndrome and is worthy of continued study to establish intervention efficacy and mechanism of action.

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Titel: Proof of Concept Study of an Oral Orthotic in Reducing Tic Severity in Tourette Syndrome
Auteurs: Shannon M. Bennett
Jeffrey S. Hindin
Justin Mohatt
Christopher Bauer
Jennifer Schild
Avital Falk
Matthew Specht
Douglas Woods
John Walkup
Publicatiedatum: 06-05-2021
Uitgeverij: Springer US
Gepubliceerd in: Child Psychiatry & Human Development / Uitgave 5/2022
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI: https://doi.org/10.1007/s10578-021-01178-7

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