Top

Research on Child and Adolescent Psychopathology

Gepubliceerd in:

01-02-2010

Exploring the Relationship Between Autistic-Like Traits and ADHD Behaviors in Early Childhood: Findings from a Community Twin Study of 2-Year-Olds

Auteurs: Angelica Ronald, Lisa R. Edelson, Philip Asherson, Kimberly J. Saudino

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 2/2010

Abstract

Behaviors characteristic of autism and ADHD emerge in early childhood, yet research investigating their comorbidity has focused on older children. This study aimed to explore the nature of the relationship between autistic-like traits and ADHD behaviors in a community sample of 2-year-olds. Twins from the Boston University Twin Project (N = 312 pairs) were assessed by their parents on autistic-like traits and ADHD behaviors using the Childhood Behavior Checklist. Phenotypic analyses showed that after controlling for general cognitive ability and socioeconomic status, autistic-like traits (total scale as well as social and nonsocial subscales) correlated positively with ADHD behaviors (r = 0.23–0.26). Structural equation model-fitting analyses revealed that there were modest shared genetic influences between ADHD- and autistic traits (genetic correlation = 0.27) as well as some common environmental influences explaining their covariation. Implications for identifying shared biological pathways underlying autistic-like traits and ADHD behaviors are discussed.

vorige artikel Evaluating the Utility of Sluggish Cognitive Tempo in Discriminating Among DSM-IV ADHD Subtypes

volgende artikel Developmental Precursors of Moral Disengagement and the Role of Moral Disengagement in the Development of Antisocial Behavior

Achenbach, T. M. & Rescorla, L. (2000). Manual for the ASEBA preschool forms and profiles. Burlington: University of Vermont: Department of Psychiatry.

Achenbach, T. M., Edelbrock, C., & Howell, C. T. (1987). Empirically based assessment of the behavioral/emotional problems of 2- and 3- year-old children. Journal of Abnormal Child Psychology, 15, 629–650.CrossRefPubMed

American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington: Author.

Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., et al. (1995). Autism as a strongly genetic disorder: evidence from a British twin study. Psychological Medicine, 25, 63–77.CrossRefPubMed

Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., et al. (2006). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the special needs and autism project (SNAP). Lancet, 368, 210–215.CrossRefPubMed

Bayley, N. (1993). Bayley scales of infant development (2nd ed.). San Antonio: The Psychological Corporation.

Clark, T., Feehan, C., Tinline, C., & Vostanis, P. (1999). Autistic symptoms in children with attention deficit-hyperactivity disorder. European Child & Adolescent Psychiatry, 8, 50–5.CrossRef

Constantino, J. N. & Todd, R. D. (2000). Genetic structure of reciprocal social behavior. American Journal of Psychiatry, 157, 2043–2045.CrossRefPubMed

Constantino, J. N. & Todd, R. D. (2003). Autistic traits in the general population: a twin study. Archives of General Psychiatry, 60(5), 524–530.CrossRefPubMed

Constantino, J. N. & Todd, R. D. (2005). Intergenerational transmission of subthreshold autistic traits in the general population. Biological Psychiatry, 57(6), 655–660.CrossRefPubMed

Constantino, J. N., Hudziak, J. J., & Todd, R. D. (2003). Deficits in reciprocal social behavior in male twins: evidence for a genetically independent domain of psychopathology. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 458–467.

de Bruin, E. I., Ferdinand, R. F., Meester, S., de Nijs, P. F., & Verheij, F. (2007). High rates of psychiatric co-morbidity in PDD-NOS. Journal of Autism and Developmental Disorders, 37(5), 877–886.CrossRefPubMed

Edelson, L. R. & Saudino, K. J. (2009). Genetic and environmental influences on autistic-like behaviors in 2-year-old twins. Behavior Genetics, 39, 255–64.CrossRefPubMed

Edelson, L. R., Ronald, A., & Saudino, K. J. (2009). The etiology of social and nonsocial components of autistic behavior in young twins. Paper presented at the International Meeting for Autism Research, Chicago, USA.

Gadow, K. D., DeVincent, C. J., Pomeroy, J., & Azizian, A. (2004). Psychiatric symptoms in preschool children with PDD and clinic and comparison samples. Journal of Autism and Developmental Disorders, 34, 379–393.CrossRefPubMed

Gadow, K. D., DeVincent, C. J., Pomeroy, J., & Azizian, A. (2005). Comparison of DSM-IV symptoms in elementary school-age children with PDD versus clinic and community samples. Autism, 9, 392–415.CrossRefPubMed

Gadow, K. D., Roohi, J., DeVincent, C. J., & Hatchwell, E. (2008). Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder. Journal of Child Psychology and Psychiatry, 49, 1331–8.CrossRefPubMed

Gadow, K. D., Roohi, J., Devincent, C. J., Kirsch, S., & Hatchwell, E. (2009). Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. Journal of Autism and Developmental Disorder, 39, 1542–1551.CrossRef

Ghaziuddin, M., Weidmer-Mikhail, E., & Ghaziuddin, N. (1998). Comorbidity of Asperger syndrome: a preliminary report. Journal of Intellectual Disability Research, 42, 279–283.CrossRefPubMed

Goldstein, S. & Schwebach, A. J. (2004). The comorbidity of pervasive developmental disorder and attention deficit hyperactivity disorder: results of a retrospective chart review. Journal of Autism and Developmental Disorders, 34(3), 329–339.CrossRefPubMed

Hattori, J., Ogino, T., Abiru, K., Nakano, K., Oka, M., & Ohtsuka, Y. (2006). Are pervasive developmental disorders and attention-deficit/hyperactivity disorder distinct disorders? Brain Development, 28(6), 371–374.CrossRefPubMed

Hoekstra, R. A., Bartels, M., Verweij, C. J., & Boomsma, D. I. (2007). Heritability of autistic traits in the general population. Archives of Pediatrics & Adolescent Medicine, 161, 372–7.CrossRef

Hoekstra, R. A., Happé, F., Baron-Cohen, S., & Ronald, A. (2009). The association between extreme autistic traits and intellectual disability: insights from a general population twin study. British Journal of Psychiatry.

Hollingshead, A. B. (1975). Four factor-index of social status. New Haven, CT: Yale University Department of Sociology.

Kim, S. J., Cox, N., Courchesne, R., Lord, C., Corsello, C., Akshoomoff, N., et al. (2002). Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder. Molecular Psychiatry, 7(3), 278–288.CrossRefPubMed

Kim, S. J., Badner, J., Cheon, K. A., Kim, B. N., Yoo, H. J., Cook, E., Jr., et al. (2005). Family-based association study of the serotonin transporter gene polymorphisms in Korean ADHD trios. American Journal of Medical Genetics B Neuropsychiatric Genetics, 139B(1), 14–18.CrossRef

Kuntsi, J., Eley, T. C., Taylor, A., Hughes, C., Asherson, P., Caspi, A., et al. (2004). Co-occurrence of ADHD and low IQ has genetic origins. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 124, 41–47.

Langley, K., Holmans, P. A., van den Bree, M. B., & Thapar, A. (2007). Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of attention deficit hyperactivity disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry, 7, 26.CrossRefPubMed

Lee, D. O. & Ousley, O. Y. (2006). Attention-deficit hyperactivity disorder symptoms in a clinic sample of children and adolescents with pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology, 16(6), 737–746.CrossRefPubMed

Levy, F., Hay, D. A., McStephen, M., Wood, C., & Waldman, I. (1997). Attention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a large-scale twin study. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 737–744.CrossRefPubMed

Leyfer, O. T., Folstein, S. E., Bacalman, S., Davis, N. O., Dinh, E., Morgan, J., et al. (2006). Comorbid psychiatric disorders in children with autism: interview development and rates of disorders. Journal of Autism and Developmental Disorders, 36(7), 849–861.CrossRefPubMed

Liang, K. Y. & Zeger, S. L. (1986). Longitudinal data analysis using generalized linear models. Biometrika, 73, 13–22.CrossRef

Loehlin, J. C. (1996). The Cholesky approach: a cautionary note. Behavior Genetics, 26, 65–69.CrossRef

McLoughlin, G., Ronald, A., Kuntsi, J., Asherson, P., & Plomin, R. (2007). Genetic support for the dual nature of attention deficit hyperactivity disorder: substantial genetic overlap between the inattentive and hyperactive-impulsive components. Journal of Abnormal Child Psychology, 35, 999–1008.CrossRefPubMed

Mulligan, A., Anney, R. J., O’Regan, M., Chen, W., Butler, L., Fitzgerald, M., et al. (2009a). Autism symptoms in attention-deficit/hyperactivity disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders. Journal of Autism and Developmental Disorders, 39, 197–209.CrossRef

Mulligan, A., Richardson, T., Anney, R. J., & Gill, M. (2009b). The social communication questionnaire in a sample of the general population of school-going children. Irish Journal of Medical Sciences, 178, 193–9.CrossRef

Najman, J. M., Williams, G. M., Nikles, J., Spence, S., Bor, W., O’Callaghan, M., et al. (2001). Bias influencing maternal reports of child behaviour and emotional state. Social Psychiatry and Psychiatric Epidemiology, 36(4), 186–194.CrossRefPubMed

Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (2003). Mx statistical modeling (6th ed.). Box 126 MCV, Richmond, VA 23298: Department of Psychology.

Nijmeijer, J. S., Hoekstra, P. J., Minderaa, R. B., Buitelaar, J. K., Altink, M. E., Buschgens, C. J., et al. (2009). PDD symptoms in ADHD, an independent familial trait? Journal of Abnormal Child Psychology, 37, 443–53.CrossRefPubMed

Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2008). Behavioral genetics (5th ed.). New York: Worth.

Price, T. S., Freeman, B., Craig, I., Petrill, S. A., Ebersole, L., & Plomin, R. (2000). Infant zygosity can be assigned by parental report questionnaire data. Twin Research, 3, 129–33.CrossRefPubMed

Price, T. S., Simonoff, E., Waldman, I., Asherson, P., & Plomin, R. (2001). Hyperactivity in preschool children is highly heritable. Journal of the American Academy of Child & Adolescent Psychiatry, 40(12), 1362–1364.CrossRef

Reiersen, A. M., Constantino, J. N., Volk, H. E., & Todd, R. D. (2007). Autistic traits in a population-based ADHD twin sample. Journal of Child Psychology & Psychiatry, 48, 464–72.CrossRef

Reiersen, A. M., Constantino, J. N., Grimmer, M., Martin, N. G., & Todd, R. D. (2008). Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins. Twin Research Human Genetics, 11, 579–585.CrossRef

Rommelse, N. N., Altink, M. E., Fliers, E. A., Martin, N. C., Buschgens, C. J., Hartman, C. A., et al. (2009). Comorbid problems in ADHD: degree of association, shared endophenotypes, and formation of distinct subtypes. Implications for a future DSM. Journal of Abnormal Child Psychology, 37, 793–804.CrossRefPubMed

Ronald, A., Happé, F., & Plomin, R. (2005). The genetic relationship between individual differences in social and nonsocial behaviours characteristic of autism. Developmental Science, 8, 444–458.CrossRefPubMed

Ronald, A., Happé, F., Bolton, P., Butcher, L. M., Price, T. S., Wheelwright, S., et al. (2006). Genetic heterogeneity between the three components of the autism spectrum: a twin study. Journal of the American Academy of Child & Adolescent Psychiatry, 45, 691–699.CrossRef

Ronald, A., Simonoff, E., Kuntsi, J., Asherson, P., & Plomin, R. (2008). Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. Journal of Child Psychology and Psychiatry, 49, 535–542.CrossRefPubMed

Santosh, P. J. & Mijovic, A. (2004). Social impairment in hyperkinetic disorder—relationship to psychopathology and environmental stressors. European Child and Adolescent Psychiatry, 13, 141–150.PubMed

Saudino, K., Ronald, A., & Plomin, R. (2005). The etiology of behavior problems in 7-year-old twins: substantial genetic influence and negligible shared environmental influence for parent ratings and ratings by same and different teachers. Journal of Abnormal Child Psychology, 33, 113–30.CrossRefPubMed

Saudino, K. J., Carter, A. S., Purper-Ouakil, D., & Gorwood, P. (2008). The etiology of behavioral problems and competencies in very young twins. Journal of Abnormal Psychology, 117, 48–62.CrossRefPubMed

Shrout, P. E. & Fleiss, J. (1979). Intraclass correlations: uses in assessing rater reliability. Psychological Bulletin, 86(2), 420–428.CrossRefPubMed

Sikora, D. M., Hall, T. A., Hartley, S. L., Gerrard-Morris, A. E., & Cagle, S. (2008). Does parent report of behavior differ across ADOS-G classifications: analysis of scores from the CBCL and GARS. Journal of Autism and Developmental Disorders, 38, 440–448.CrossRefPubMed

Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child & Adolescent Psychiatry, 47, 921–929.CrossRef

Sinzig, J., Walter, D., & Doepfner, M. (2009). Attention deficit/hyperactivity disorder in children and adolescents with autism spectrum disorder: symptom or syndrome? Journal of Attentional Disorders, 13, 117–126.CrossRef

Skuse, D. H., Mandy, W. P., & Scourfield, J. (2005). Measuring autistic traits: heritability, reliability and validity of the social and communication disorders checklist. British Journal of Psychiatry, 187, 568–572.CrossRefPubMed

Smalley, S. L., Kustanovich, V., Minassian, S. L., Stone, J. L., Ogdie, M. N., McGough, J. J., et al. (2002). Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism. American Journal of Human Genetics, 71, 959–963.CrossRefPubMed

Yoshida, Y. & Uchiyama, T. (2004). The clinical necessity for assessing attention deficit/hyperactivity disorder symptoms in children with high-functioning pervasive developmental disorder. European Child & Adolescent Psychiatry, 13, 307–314.CrossRef

Titel: Exploring the Relationship Between Autistic-Like Traits and ADHD Behaviors in Early Childhood: Findings from a Community Twin Study of 2-Year-Olds
Auteurs: Angelica Ronald
Lisa R. Edelson
Philip Asherson
Kimberly J. Saudino
Publicatiedatum: 01-02-2010
Uitgeverij: Springer US
Gepubliceerd in: Research on Child and Adolescent Psychopathology / Uitgave 2/2010
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI: https://doi.org/10.1007/s10802-009-9366-5

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 2/2010

Developmental Precursors of Moral Disengagement and the Role of Moral Disengagement in the Development of Antisocial Behavior

Mothers as a Resource in Times of Stress: Interactive Contributions of Socialization of Coping and Stress to Youth Psychopathology

Relations Among Perceived Control Over Anxiety-Related Events, Worry, and Generalized Anxiety Disorder in a Sample of Adolescents

Anxiety as a Predictor of Age at First Use of Substances and Progression to Substance Use Problems Among Boys

ADHD and Working Memory: The Impact of Central Executive Deficits and Exceeding Storage/Rehearsal Capacity on Observed Inattentive Behavior

Interrelations Between Executive Function and Symptoms of Hyperactivity/Impulsivity and Inattention in Preschoolers: A Two Year Longitudinal Study