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Inhibitory deficits in attention-deficit/hyperactivity disorder are independent of basic processing efficiency and IQ

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Summary

Background. A substantial proportion of children with attention-deficit/hyperactivity disorder (ADHD) show deficits on inhibitory control tests. However, questions remain about (i) the extent of these deficits across different inhibitory domains, (ii) their relationship to deficits in non-executive processes and (iii) whether they extend into adolescence.

Methods. Seventy-seven children and adolescents with ADHD and 50 non-ADHD controls completed three inhibitory tasks, a simple two choice RT task (2CR) and an IQ assessment.

Results. ADHD was moderately associated with deficits on all tasks (effect sizes d=0.5–0.9). Deficits were equally marked in childhood and adolescence. Inhibitory deficits were not associated with IQ and, although reduced substantially, remained significant after performance on a simple reaction time task was controlled for statistically.

Discussion. In highlighting the significant, but limited, role of inhibitory deficits in ADHD, these results are consistent with recent accounts that emphasize the neuropsychological heterogeneity of this condition.

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References

  • P Andreou BM Neale W Chen H Christiansen I Gabriels A Heise S Meidad UC Muller H Uebel T Banaschewski I Manor R Oades H Roeyers A Rothenberger P Sham HC Steinhausen P Asherson J Kuntsi (2007) ArticleTitleReaction time performance in ADHD: improvement under fast-incentive condition and familial effects Psychol Med 31 1–13

    Google Scholar 

  • RA Barkley (1997) ArticleTitleBehavioural inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD Psychol Bull 121 65–94 Occurrence Handle9000892 Occurrence Handle10.1037/0033-2909.121.1.65 Occurrence Handle1:STN:280:DyaK2s7lsVSnug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SK Berument M Rutter C Lord A Pickles A Bailey (1999) ArticleTitleAutism screening questionnaire: diagnostic validity Br J Psychiatry 175 444–451 Occurrence Handle10789276 Occurrence Handle1:STN:280:DC%2BD3c3kvFOmsA%3D%3D Occurrence Handle10.1192/bjp.175.5.444

    Article  PubMed  CAS  Google Scholar 

  • Bitsakou P (2007) Dissecting the neuropsychological structure of ADHD: inhibitory control and delay aversion. Unpublished doctoral thesis, University of Southampton, Southampton, UK

  • K Brookes X Xu W Chen K Zhou B Neale N Lowe R Aneley B Franke M Gill R Ebstein J Buitelaar et al. (2006) ArticleTitleThe analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes Mol Psychiatry 11 IssueID10 934–953 Occurrence Handle16894395 Occurrence Handle10.1038/sj.mp.4001869 Occurrence Handle1:CAS:528:DC%2BD28XhtVSnsrfE

    Article  PubMed  CAS  Google Scholar 

  • BJ Casey N Tottenham C Liston S Durston (2005) ArticleTitleImaging the developing brain: What have we learned about cognitive development? Trends Cognit Sci 9 IssueID3 104–110 Occurrence Handle10.1016/j.tics.2005.01.011 Occurrence Handle1:STN:280:DC%2BD2M7gvVGrtg%3D%3D

    Article  CAS  Google Scholar 

  • FX Castellanos R Tannock (2002) ArticleTitleNeuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes Nat Rev Neurosci 3 617–628 Occurrence Handle12154363 Occurrence Handle1:CAS:528:DC%2BD38XlslGrt7k%3D

    PubMed  CAS  Google Scholar 

  • FX Castellanos EJS Sonuga-Barke A Scheres A Di Martino C Hyde JR Walters (2005) ArticleTitleVarieties of attention-deficit/hyperactivity disorder-related intra-individual variability Biol Psychiatry 57 IssueID11 1416–1423 Occurrence Handle15950016 Occurrence Handle10.1016/j.biopsych.2004.12.005

    Article  PubMed  Google Scholar 

  • J Cohen (1992) ArticleTitleA power primer Psychol Bull 112 155–159 Occurrence Handle10.1037/0033-2909.112.1.155 Occurrence Handle19565683 Occurrence Handle1:STN:280:DC%2BD1MvlsV2mug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • K Conners (Eds) (1996) Rating scales in ADHD Duke University Medical Centre Durham NC

    Google Scholar 

  • AE Doyle S Faraone LJ Seidman EG Willcutt JT Nigg ID Waldman BF Pennington J Peart J Biederman (2005) ArticleTitleAre endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD? J Child Psychol Psychiatry 46 IssueID7 774–803 Occurrence Handle15972070 Occurrence Handle10.1111/j.1469-7610.2005.01476.x

    Article  PubMed  Google Scholar 

  • R Drechsler D Brandeis M Földényi K Imhof H-C Steinhausen (2005) ArticleTitleThe course of neuropsychological functions in children with attention deficit hyperactivity disorder from late childhood to early adolescence J Child Psychol Psychiatry 46 IssueID8 824–836 Occurrence Handle16033631 Occurrence Handle10.1111/j.1469-7610.2004.00384.x

    Article  PubMed  Google Scholar 

  • BA Eriksen CW Eriksen (1974) ArticleTitleEffects of noise letters upon identification of a target letter in a nonsearch task Percept Psychophys 16 143–149

    Google Scholar 

  • TW Frazier HA Demaree EA Youngstrom (2004) ArticleTitleMeta-analysis of intellectual and neuropsychological test performance in attention-deficit/hyperactivity disorder Neuropsychology 8 IssueID3 543–555 Occurrence Handle10.1037/0894-4105.18.3.543

    Article  Google Scholar 

  • R Goodman (1997) ArticleTitleThe strengths and difficulties questionnaire: a research note J Child Psychol Psychiatry 38 581–586 Occurrence Handle9255702 Occurrence Handle10.1111/j.1469-7610.1997.tb01545.x Occurrence Handle1:STN:280:DyaK2szpvFKjsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SP Hinshaw ET Carte C Fan JS Jassy EB Owens (2007) ArticleTitleNeuropsychological functioning of girls with attention-deficit/hyperactivity disorder followed prospectively into adolescence: evidence for continuing deficits? Neuropsychology 21 IssueID2 263–273 Occurrence Handle17402826 Occurrence Handle10.1037/0894-4105.21.2.263

    Article  PubMed  Google Scholar 

  • AM Hogan F Vergha-Khadem FJ Kirkham T Baldeweg (2005) ArticleTitleMaturation of action monitoring from adolescents to adulthood: an ERP study Dev Sci 8 IssueID6 525–534 Occurrence Handle16246244 Occurrence Handle10.1111/j.1467-7687.2005.00444.x

    Article  PubMed  Google Scholar 

  • J Kuntsi J Oosterlaan J Stevenson (2001) ArticleTitlePsychological mechanisms in hyperactivity: I. Response inhibition deficit, working memory impairment, delay aversion, or something else? J Child Psychol Psychiatry 42 199–210 Occurrence Handle11280416 Occurrence Handle10.1017/S0021963001006709 Occurrence Handle1:STN:280:DC%2BD3M7ovVOgsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • J Kuntsi TC Eley A Taylor C Hughes P Asherson A Caspi TE Moffitt (2004) ArticleTitleCo-occurrence of ADHD and low IQ has genetic origins Am J Med Genet B Neuropsychiatry Genet 124 IssueID1 41–47 Occurrence Handle10.1002/ajmg.b.20076 Occurrence Handle1:STN:280:DC%2BD3srpvVyqsw%3D%3D

    Article  CAS  Google Scholar 

  • GD Logan (1994) On the ability to inhibit thought and action: a users’ guide to the stop signal paradigm D Dagenbach TH Carr (Eds) Inhibitory processes in attention, memory, and language Academic Press San Diego 189–239

    Google Scholar 

  • F Nichelli G Scala C Vago D Riva S Bulgheroni (2005) ArticleTitleAge-related trends in stroop and conflicting motor response task findings Child Neuropsychol 11 431–443 Occurrence Handle16306018 Occurrence Handle10.1080/09297040590951569

    Article  PubMed  Google Scholar 

  • JT Nigg (2001) ArticleTitleIs ADHD a disinhibitory disorder? Psychol Bull 127 571–598 Occurrence Handle11548968 Occurrence Handle10.1037/0033-2909.127.5.571 Occurrence Handle1:STN:280:DC%2BD3MvpvFOltw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • JT Nigg (2005) ArticleTitleNeuropsychologic theory and finding in attention-deficit/hyperactivity disorder: the state of the field and salient challenges from the coming decade Biol Psychiatry 57 1424–1435 Occurrence Handle15950017 Occurrence Handle10.1016/j.biopsych.2004.11.011

    Article  PubMed  Google Scholar 

  • JT Nigg (Eds) (2006) What causes ADHD? Understanding what goes wrong and why Guilford Press New York

    Google Scholar 

  • JT Nigg EG Willcutt AE Doyle EJS Sonuga-Barke (2005) ArticleTitleCausal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes? Biol Psychiatry 57 1224–1230 Occurrence Handle15949992 Occurrence Handle10.1016/j.biopsych.2004.08.025

    Article  PubMed  Google Scholar 

  • J Oosterlaan GD Logan J Sergeant (1998) ArticleTitleResponse inhibition in ADHD, CD, comorbid ADHD+CD, anxious, and control children: a meta-analysis of studies with the stop task J Child Psychol Psychiatry 39 411–425 Occurrence Handle9670096 Occurrence Handle10.1017/S0021963097002072 Occurrence Handle1:STN:280:DyaK1czjsVOmsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • TJ Polderman MF Gosso D Posthuma TC van Beijsterveldt P Heutink FC Verhulst DI Boomsma (2006) ArticleTitleA longitudinal twin study on IQ, executive functioning, and attention problems during childhood and early adolescence Acta Neurol Belg 106 IssueID4 191–207 Occurrence Handle17323837

    PubMed  Google Scholar 

  • SM Rhodes DR Coghill K Matthews (2006) ArticleTitleAcute neuropsychological effects of methylphenidate in stimulant drug-naïve boys with ADHD II – broader executive and non-executive domains J Child Psychol Psychiatry 47 IssueID11 1184–1194 Occurrence Handle17076758 Occurrence Handle10.1111/j.1469-7610.2006.01633.x

    Article  PubMed  Google Scholar 

  • CA Riccio S Homack KP Jarratt ME Wolfe (2006) ArticleTitleDifferences in academic and executive function domains among children with ADHD Predominantly Inattentive and Combined Types Arch Clin Neuropsychol 21 IssueID7 657–667 Occurrence Handle16920328 Occurrence Handle10.1016/j.acn.2006.05.010

    Article  PubMed  Google Scholar 

  • K Rubia E Taylor AB Smith H Oksannen S Overmeyer ET Bullmore S Newman (2001) ArticleTitleNeuropsychological analyses of impulsiveness in childhood hyperactivity Br J Psychiatry 179 138–143 Occurrence Handle11483475 Occurrence Handle10.1192/bjp.179.2.138 Occurrence Handle1:STN:280:DC%2BD3MvjslCksg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • K Rubia A Smith E Taylor (2007) ArticleTitlePerformance of children with attention deficit hyperactivity disorder (ADHD) on a test battery of impulsiveness Child Neuropsychol 13 IssueID3 276–304 Occurrence Handle17453834 Occurrence Handle10.1080/09297040600770761

    Article  PubMed  Google Scholar 

  • JM Sattler (Eds) (1992) Assessment of children: WISC-III and WPPSI-R Supplement Sattler JM San Diego, CA

    Google Scholar 

  • JA Sergeant (2005) ArticleTitleModelling ADHD: a critical appraisal of the cognitive-energetic model Biol Psychiatry 57 IssueID11 1248–1255 Occurrence Handle15949995 Occurrence Handle10.1016/j.biopsych.2004.09.010

    Article  PubMed  Google Scholar 

  • Sergeant JA, Willcutt E, Nigg J (in press) How clinically functional are executive function measures of ADHD? In: Shaffer D, Leibenluft E, Rohde LA, Sirovatka P, Regier DA (eds) Externalizing disorders of childhood: refining the research agenda for DSM-V. American Psychiatric Association, Arlington, VA

  • EJ Sonuga-Barke (2002) ArticleTitlePsychological heterogeneity in AD/HD – a dual pathway model of behaviour and cognition Behav Brain Res 130 29–36 Occurrence Handle11864715 Occurrence Handle10.1016/S0166-4328(01)00432-6

    Article  PubMed  Google Scholar 

  • EJ Sonuga-Barke (2003) ArticleTitleThe dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics Neurosci Biobehav Rev 27 593–604 Occurrence Handle14624804 Occurrence Handle10.1016/j.neubiorev.2003.08.005

    Article  PubMed  Google Scholar 

  • EJ Sonuga-Barke (2005) ArticleTitleCausal models of attention-deficit/hyperactivity disorder: from common simple deficits to multiple developmental pathways Biol Psychiatry 57 IssueID11 1231–1238 Occurrence Handle15949993 Occurrence Handle10.1016/j.biopsych.2004.09.008

    Article  PubMed  Google Scholar 

  • Sonuga-Barke EJ, Sergeant J, Nigg J, Willcutt E (2007) Executive dysfunction and delay aversion in ADHD: nosological and diagnostic implications. Child Adolesc Psychiatry Clin N Am (in press)

  • JR Stroop (1935) ArticleTitleStudies of interference in serial verbal reactions J Expl Psychol 18 643–662 Occurrence Handle10.1037/h0054651

    Article  Google Scholar 

  • E Taylor G Sandberg G Thorley S Giles (1991) The epidemiology of childhood hyperactivity. Maudsley Monograph No. 33 Oxford University Press Oxford

    Google Scholar 

  • R van Mourik J Oosterlaan JA Sergeant (2005) ArticleTitleThe Stroop revisited: a meta-analysis of interference control in AD/HD J Child Psychol Psychiatry 46 150–165 Occurrence Handle15679524 Occurrence Handle10.1111/j.1469-7610.2004.00345.x

    Article  PubMed  Google Scholar 

  • D Wechsler (1991) Wechsler Intelligence Scale for Children EditionNumber3 Psychological Corporation San Antonio, TX

    Google Scholar 

  • EG Willcutt AE Doyle JT Nigg SV Faraone BF Pennington (2005) ArticleTitleValidity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review Biol Psychiatry 57 1336–1346 Occurrence Handle15950006 Occurrence Handle10.1016/j.biopsych.2005.02.006

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute for Disorder on Impulse and Attention, University of Southampton, Southampton, UK

    P. Bitsakou, M. Thompson & E. J. S. Sonuga-Barke

  2. Department of Child and Adolescent Psychiatry, University of Oxford, Oxford, UK

    L. Psychogiou

  3. Child Study Center, New York University, New York, USA

    E. J. S. Sonuga-Barke

  4. Social, Genetic, Developmental Psychiatry Centre, Institute of Psychiatry, London, UK

    E. J. S. Sonuga-Barke

Authors
  1. P. Bitsakou
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  2. L. Psychogiou
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  3. M. Thompson
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  4. E. J. S. Sonuga-Barke
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Correspondence to E. J. S. Sonuga-Barke.

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Correspondence: Edmund J. S. Sonuga-Barke, Institute for Disorder on Impulse and Attention, School of Psychology, University of Southampton, Highfield, Southampton SO17 1BJ, UK

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Bitsakou, P., Psychogiou, L., Thompson, M. et al. Inhibitory deficits in attention-deficit/hyperactivity disorder are independent of basic processing efficiency and IQ. J Neural Transm 115, 261–268 (2008). https://doi.org/10.1007/s00702-007-0828-z

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  • DOI: https://doi.org/10.1007/s00702-007-0828-z

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