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Treatment of Orthostatic Hypotension

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Aging and Drug Therapy

Part of the book series: Ettore Majorana International Science Series ((PSLI))

Abstract

A critical component of the aging process is the inability to maintain homeostasis. Orthostatic (postural) hypotension (OH) is a good example of homeostatic failure which may be due to aging or to disease but is not infrequently predominantly iatrogenic. It is a serious disorder with potentially catastrophic complications including falls, fractures, infarction of brain and heart, immobility and increasing dependency. Orthostatic, hypotension is not a single nosological entity and the clinical classification, pathology, biochemistry and treatment remain a challenge.1

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References

  1. R. J. Polinski, I. J. Kopin, M. H. Ebert, and V. Weise, Pharmacologic distinction of different orthostatic hypotension syndromes, Neurology 31: 1 (1981).

    Article  Google Scholar 

  2. Editorial, Management of drthostatic hypotension, Lancet 2: 963 (1981).

    Google Scholar 

  3. L. Wollner and J. M. K. Spalding, The autonomic nervous system, in: “Textbook of Geriatric Medicine and Gerontology”, J. C. Brocklehurst, ed., Churchill Livingstone, Edinburgh (1978).

    Google Scholar 

  4. L. Wollner, S. T. McCarthy, N. D. W. Soper, and D. J. Macy, Failure of cerebral autoregulation as a cause of brain dysfunction in the elderly, Br.med.J. 1: 1117 (1979).

    Google Scholar 

  5. K. J. Collins, A. N. Exton-Smith, M. H. James, and D. J. Oliver, Functional changes, in autonomic nervous responses with ageing, Age and Ageing, 9: 17 (1980).

    Article  Google Scholar 

  6. J. W. Davie, M. D. Blumenthal, and S. Robinson-Hawkins, A model of risk of falling for psychogeriatric patients, Arch.gen.Psych. 38:463 (1981).

    Article  Google Scholar 

  7. R. H. Johnson, A. C. Smith, J. M. K. Spalding, and L. Wollner., Effect of posture on blood pressure in elderly patents, Lancet 1: 731 (1965).

    Article  Google Scholar 

  8. A. J. Campbell, J. Reinken, B. C. Allen, and G. S. Martinez, Falls in old age: A study of frequency and related clinical factors, Age and Ageing 10: 264 (1981)

    Article  Google Scholar 

  9. D. J. Ewing, I. Campbell, A. Murray, J. M. M. Neilson, and B. F. Clarke, Immediate heart-rate response to standing: simple test for autonomic neuropathy in diabetes, Br.med.J. 1: 145 (1978).

    Article  Google Scholar 

  10. G. Keren, Y. Epstein, A. Ohri and A. Magazanik, Orthostatic responses in heat tolerant and intolerant subjects compared by three different methods. Aviat.Space Environ.Med. 51: 1205 (1980).

    Google Scholar 

  11. R. B. Hickler, Orthostatic hypotension and syncope, New Engl.J.Med. 296:336 (1977).

    Article  Google Scholar 

  12. F. I. Caird, G. B. Andrews, and R. D. Kennedy, Effect of posture on blood pressure in the elderly. Br.Heart J. 35: 527 (1973).

    Article  Google Scholar 

  13. W. J. MacLennan, M. R. P. Hall, and J. I. Timothy, Postural hypotension in old age: is it a disorder of the nervous system or the blood vessels? Age and Ageing 9: 25 (1980)

    Article  Google Scholar 

  14. E. Vargas and M. Lye, The assessment of autonomic function in the elderly, Age and Ageing 9: 210 (1980).

    Article  Google Scholar 

  15. W. B. White, L. Reik and D. E. Cutlip, Pernicious anemia seen initially as orthostatic hypotension, Arch.int.Med. 141: 1543 (1981).

    Article  Google Scholar 

  16. W. Fine, Some common factors in the causation of postural hypotension. Geront.clin. 11: 206 (1969).

    Article  Google Scholar 

  17. J. R. Cox, A. K. Admani, M. L. Agarwal,and P. Abel, Postural hypotension - body fluid compartments and electrolytes. Age and Ageing 2: 112 (1973).

    Article  Google Scholar 

  18. I. J. Schatz, Current management concepts in orthostatic bypotension, Arch.int.Med. 140:1152 (1980 1/4

    Article  Google Scholar 

  19. R. Bannister, Chronic autonomic failure with postural hypotension, Lancet 2: 404 (1979).

    Google Scholar 

  20. R. Nanda, R. Johnson,and H. Keogh, Treatment of neurogenic orthostatic hypotension with a monoamine oxidase inhibitor and tyramine, Lancet 2: 1164 (1976).

    Article  Google Scholar 

  21. S. J. Watt, J. E. Tooke, C. M. Perkins, and M. R. Lee, The treatment of idiopathic orthostatic hypotension: a combined fludrocortisone and flurbiprofen regime, Q.J.Med. 50: 205 (1981).

    Google Scholar 

  22. J. F. Macias Nunez, C. Garcias Inglesias, J. M. Taberno Romo, J. L. Rodrigues Comes, L. Corbacho Becerra, and J. A. Sanchez Tomero, Renal management of sodium under indomethacin and aldosterone in the elderly, Age and Ageing 9: 165 (1980).

    Article  Google Scholar 

  23. A. J. Man in′t Veld and M. A. D. H. Schalenkamp, Pindolol acts as beta-adrenoceptor agonist in orthostatic hypotension: therapeutic implications, Br.med.J. 282: 929 (1981).

    Article  Google Scholar 

  24. B. Davies, R. Bannister, C. Mathias, and P. Sever, Pindolol in postural hypotension: the case for caution, Lancet 2: 982 (1981).

    Article  Google Scholar 

  25. A. J. Man in′t Veld and M. A. D. H. Schalenkamp, Pindolol in postural hypotension, Lancet 2: 1279 (1981).

    Google Scholar 

  26. D. Robertson, M. R. Goldberg, A. S. Hollister, D. Wade. and R. M. Robertson, Clonidine raises blood pressure in idiopathic orthostatic hypotension, Circulation 64: (Supp.V) 10 (1981).

    Google Scholar 

  27. A. J. Lees and R. Bannister, The use of lisuride in the treatment of multiple system atrophy with autonomic failure (Shy-Drager syndrome) J.Neurol.Neurosurg.Psychiat. 44: 347 (1981).

    Article  Google Scholar 

  28. Y. Lecrubier, A. J. Puech and A. des Lauriers, Favourable effects of yohimbine on clomipramine-induced orthostatic hypotension: a double blind study, Br.Clin.Pharmacol. 12: 90 (1981).

    Google Scholar 

  29. I. N. Olver, G. L. Jennings, A. Bobik,and M. Esler, Low bioavailability as a cause of apparent failure of dihydroergotamine in orthostatic hypotension, Br.med.J. 281: 275 (1980).

    Article  Google Scholar 

  30. A. J. Moss, W. Glaser, and E. Topol, Atrial tachypacing in the treatment of a patient with primary orthostatic hypotension, N. Engl.J.Med. 302:1456 (1980).

    Article  Google Scholar 

  31. D. H. Jones and J. L. Reid, Volume expansion and vasodilators in the treatment of idiopathic postural hypotension. Postgrad.med.J. 56: 234 (1980).

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Consultant Physician in Geriatric Medicine, Addenbrooke’s Hospital, Cambridge, UK

    William Davison

Authors
  1. William Davison
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Editor information

Editors and Affiliations

  1. Institute of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy

    G. Barbagallo-Sangiorgi

  2. School of Medicine, University College London, London, England

    A. N. Exton-Smith

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© 1984 Plenum Press, New York

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Davison, W. (1984). Treatment of Orthostatic Hypotension. In: Barbagallo-Sangiorgi, G., Exton-Smith, A.N. (eds) Aging and Drug Therapy. Ettore Majorana International Science Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2791-2_29

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  • DOI: https://doi.org/10.1007/978-1-4613-2791-2_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9721-5

  • Online ISBN: 978-1-4613-2791-2

  • eBook Packages: Springer Book Archive

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