Gepubliceerd in:
01-06-2010 | Original article
Guideline adherence for antithrombotic therapy in acute coronary syndrome: an overview in Dutch hospitals
Auteurs:
W. J. Kikkert, J. J. Piek, R. J. de Winter, R. J. Peters, J. P. S. Henriques
Gepubliceerd in:
Netherlands Heart Journal
|
Uitgave 6/2010
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Extract
Plaque rupture or erosion with superimposed coronary thrombus formation is the instigating event in acute coronary syndrome (ACS). Total occlusion of the coronary artery is associated with ST-elevation myocardial infarction (STEMI), whereas partial or intermittent coronary occlusion is associated with unstable angina and non-ST-elevation myocardial infarction (UA/NSTEMI). Antithrombotic agents, divided in anticoagulant and antiplatelet agents, mitigate coronary thrombosis, prevent recurrent ischaemia and prevent thromboembolic complications related to percutaneous coronary intervention (PCI). Different antithrombotic agents have distinct efficacy and safety profiles. To aid physicians in making a decision in the selection of antithrombotic agents, guidelines for the management of ACS have been drawn up by expert committees of the European Society of Cardiology (ESC) and the American Heart Association/American College of Cardiology (AHA/ACC). To investigate if these guidelines are actually applied in clinical medicine, we conducted a survey of antithrombotic treatment in current Dutch clinical practice for ACS. …