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Pathophysiologie

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Tscherne Unfallchirurgie

Zusammenfassung

Beim polytraumatisierten Patienten folgt auf den traumatisch-hämorrhagischen Schock ein äußerst komplexes multifokales pathophysiologisches Geschehen, welches prinzipiell zum Ziel hat, den durch das Trauma entstandene Gewebeschaden abzubauen und eine Regeneration zu erzielen. Die Summe dieser Reaktionen wird als ≫host defense response≪ bezeichnet. Aufgrund der besonderen Situation beim schwerstverletzten Patienten laufen diese Reaktionen häufig nicht mehr geordnet ab, einzelne Systeme aktivieren bzw. potenzieren sich sogar gegenseitig. Gemeinsame Endstrecke dieser Reaktionen ist die Entwicklung eines Einzel- oder Multiorganversagens.

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Literatur

  • Aggarwal BB, Kohr WJ, Hass PE et al. (1985) Human tumor necrosis factor. Production, purification, and characterization. J Biol Chem 260: 2345–2354

    PubMed  CAS  Google Scholar 

  • Ashbaugh DG, Bigelow DB, Petty TL, Levine BE (1967) Acute respiratory distress in adults. Lancet 2: 319–323

    PubMed  CAS  Google Scholar 

  • Ayala A, Wang P, Ba ZF, Perrin MM, Ertel W, Chaudry IH (1991) Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage. Am J Physiol 260: R167–R171

    PubMed  CAS  Google Scholar 

  • Bankey PE, Cerra FB (1993) Hepatic dysfunction in shock and organ failure. In: Schlag G, Redl H (eds) Pathophysiology of shock, sepsis and organ failure. Springer, Berlin Heidelberg New York Tokyo, pp 948–960

    Google Scholar 

  • Banks RO, Gallavan RH Jr, Zinner MH, Bulkley GB, Harper SL, Granger DN, Jacobson ED (1985) Vasoactive agents in control of the mesenteric circulation. Fed Proc 44: 2743–2749

    PubMed  CAS  Google Scholar 

  • Bao S, Goldstone S, Husband AJ (1993) Localization of IFN-gamma and IL-6 mRNA in murine intestine by in situ hybridization. Immunology 80: 666–670

    PubMed  CAS  Google Scholar 

  • Barie PS, Hydo LJ, Fischer E (1994) A prospective comparison of two multiple organ dysfunction/failure scoring systems for prediction of mortality in critical surgical illness. J Trauma 37: 660–666

    PubMed  CAS  Google Scholar 

  • Baue AE (1975) Multiple, progressive, or sequential systems failure. A syndrome of the 1970s. Arch Surg 110: 779–781

    PubMed  CAS  Google Scholar 

  • Berg RD, Garlington AW (1979) Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immunnol 23: 403–411

    CAS  Google Scholar 

  • Bergmann MJ, Guerrant RL, Murad F, Richardson SH, Weaver D, Mandell GL (1978) Interaction of polymorphonuclear neutrophils with Escherichia coli. Effect of enterotoxin on phagocytosis, killing, Chemotaxis, and cyclic AMP. J Clin Invest 61: 227–234

    Google Scholar 

  • Beutler B, Krochin N, Milsark IW, Luedke C, Cerami A (1986) Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science 232: 977–980

    PubMed  CAS  Google Scholar 

  • Bone LB, Johnson KD, Weigelt J, Scheinberg R (1989) Early versus delayed stabilization of femoral fractures. A prospective randomized study. J Bone Joint Surg Am 71: 336–340

    PubMed  CAS  Google Scholar 

  • Bone RC, Balk RA, Cerra FB et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine [see comments]. Chest 101: 1644–1655

    PubMed  CAS  Google Scholar 

  • Border JR, Chenier R, McManamy RH, La Duca J, Seibel R, Birkhahn R, Yu L (1976) Multiple systems organ failure: muscle fuel deficit with visceral protein malnutrition. Surg Clin North Am 56: 1147–1167

    PubMed  CAS  Google Scholar 

  • Border JR, Hassett J, LaDuca J et al. (1987) The gut origin septic states in blunt multiple trauma (ISS = 40) in the ICU. Ann Surg 206: 427–448

    PubMed  CAS  Google Scholar 

  • Braegger CP, MacDonald TT (1994) Immune mechanisms in chronic inflammatory bowel disease. Ann Allergy 72: 135–141

    PubMed  CAS  Google Scholar 

  • Breese EJ, Michie CA, Nicholls SW et al. (1994) Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 106: 1455–1466

    PubMed  CAS  Google Scholar 

  • Bulkley GB, Kvietys PR, Parks DA, Perry MA, Granger DN (1985) Relationship of bloos flow and oxygen consumption to ischemic injury in the canine small intestine. Gastroenterology 89: 852–857

    PubMed  CAS  Google Scholar 

  • Cain SM, Curtis SE (1991) Experimental models of pathologic oxygen supply dependency. Crit Care Med 19: 603–612

    PubMed  CAS  Google Scholar 

  • Cerf Bensussan N, Guy Grand D, Griscelli C (1985) Intraepithelial lymphocytes of human gut: isolation, characterisation and study of natural killer activity. Gut 26: 81–88

    Google Scholar 

  • Cerra FB (1987) Hypermetabolism, organ failure, and metabolic support. Surgery 101: 1–14

    PubMed  CAS  Google Scholar 

  • Chapnick BM, Feigen LP, Hyman AL, Kadowitz PJ (1978) Differential effects of Prostaglandins in the mesenteric vascular bed. Am J Physiol 235: H326–H332

    PubMed  CAS  Google Scholar 

  • Chiu CJ, McArdle AH, Brown R, Scott HJ, Gurd FN (1970) Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg 101: 478–483

    PubMed  CAS  Google Scholar 

  • Cioffi WG, Burleson DG, Pruitt BA Jr (1993) Leukocyte responses to injury. Arch Surg 128: 1260–1267

    PubMed  CAS  Google Scholar 

  • Committee on Injury Scaling (1990) Abbreviated Injury Scale 1990 Revision. Association for the Advancement of Automovement Medicine, Des Plaines, Illinois

    Google Scholar 

  • Copes WS, Champion HR, Sacco WJ, Lawnick MM, Keast SL, Bain LW (1988) The Injury Severity Score revisited. J Trauma 28: 69–77

    PubMed  CAS  Google Scholar 

  • Crump JM, Duncan DA, Wears R (1988) Analysis of multiple organ system failure in trauma and nontrauma patients. Am Surg 54: 702–708

    PubMed  CAS  Google Scholar 

  • Deitch EA (1990) Intestinal permeability is increased in burn patients shortly after injury. Surgery 107: 411–416

    PubMed  CAS  Google Scholar 

  • Deitch EA (1992) Multiple organ failure. Pathophysiology and potential future therapy [see comments]. Ann Surg 216: 117–134

    PubMed  CAS  Google Scholar 

  • Deitch EA (1993) Multiple organ failure. Adv Surg 26: 333–356

    PubMed  CAS  Google Scholar 

  • Deitch EA, Xu D, Franko L, Ayala A, Chaudry IH (1994) Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock. Shock 1: 141–146

    PubMed  CAS  Google Scholar 

  • DeLisser HM, Newman PJ, Albelda SM (1994) Molecular and functional aspects of PECAM-1/CD31. Immunol Today 15: 490–495

    PubMed  CAS  Google Scholar 

  • Demling RH (1987) Pulmonary edema: current concepts of pathophysiology, clinical significance, and methods of measurement. World J Surg 11: 147–153

    PubMed  CAS  Google Scholar 

  • Djeu JY, Blanchard DK, Richards AL, Friedman H (1988) Tumor necrosis factor induction by Candida albicans from human natural killer cells and monocytes. J Immunol 141: 4047–4052

    PubMed  CAS  Google Scholar 

  • Dorinsky PM, Gadek JE (1989) Mechanisms of multiple nonpulmonary organ failure in ARDS. Chest 96: 885–892

    PubMed  CAS  Google Scholar 

  • Dosquet C, Weill D, Wautier JL (1992) Molecular mechanism of blood monocyte adhesion to vascular endothelial cells. Nouv Rev Fr Hematol 34(Suppl): S55–S59

    PubMed  CAS  Google Scholar 

  • Eiseman B, Beart R, Norton L (1977) Multiple organ failure. Surg Gynecol Obstet 144: 323–326

    PubMed  CAS  Google Scholar 

  • Faist E, Baue AE, Dittmer H, Heberer G (1983) Multiple organ failure in polytrauma patients. J Trauma 23: 775–787

    PubMed  CAS  Google Scholar 

  • Faist E, Hartl HW, Baue AE (1994) Immunmechanistik der posttraumatischen Hyperinflammation. Immun Infekt 22: 203–213

    PubMed  CAS  Google Scholar 

  • Fink MP (1991) Gastrointestinal mucosal injury in experimental models of shock, trauma, and sepsis. Crit Care Med 19: 627–641

    PubMed  CAS  Google Scholar 

  • Fischer E, Marano MA, Barber AE et al. (1991) Comparison between effects of interleukin-1 alpha administration and sublethal endotoxemia in primates. Am J Physiol 261: R442–R452

    PubMed  CAS  Google Scholar 

  • Fong Y, Moldawer LL, Shires GT, Lowry SF (1990) The biologic characteristics of cytokines and their implication in surgical injury. Surg Gynecol Obstet 170: 363–378

    PubMed  CAS  Google Scholar 

  • Friedmann BC, Williams JF, Knauss WA (1993) Multi-system organ failure (MSOF): outcome and clinical implications. (Abstract)

    Google Scholar 

  • Fry DE, Pearlstein L, Fulton RL, Polk HC Jr (1980) Multiple system organ failure. The role of uncontrolled infection. Arch Surg 115: 136–140

    PubMed  CAS  Google Scholar 

  • Fulton R, Jones C (1975) The cause of post-traumatic respiratory insufficiency in man. Surg Gynecol Obstet 140: 179–184

    PubMed  CAS  Google Scholar 

  • Fulton RL, Peter ET (1970) The progressive nature of pulmonary contusion. Surgery 67: 499–506

    PubMed  CAS  Google Scholar 

  • Gamble JR, Harlan JM, Klebanoff SJ, Vadas MA (1985) Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor. Proc Natl Acad Sci USA 82: 8667–8671

    PubMed  CAS  Google Scholar 

  • Goldfarb MA, Ciurej TF, McAslan TC, Sacco WJ, Weinstein MA, Cowley RA (1975) Tracking respiratory therapy in the trauma patient. Am J Surg 129: 255–258

    PubMed  CAS  Google Scholar 

  • Goris RJ, Gimbrere JS, van Niekerk JL, Schoots FJ, Booy LH (1982) Early osteosynthesis and prophylactic mechanical ventilation in the multitrauma patient. J Trauma 22: 895–903

    PubMed  CAS  Google Scholar 

  • Granger DN, McCord JM, Parks DA, Hollwarth ME (1986) Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine. Gastroenterology 90: 80–84

    PubMed  CAS  Google Scholar 

  • Granger DN, Rutili G, McCord JM (1981) Superoxide radicals in feline intestinal ischemia. Gastro enterology 81: 22–29

    CAS  Google Scholar 

  • Günther S, Gimbrone MA Jr, Alexander RW (1980) Identification and characterization of the high affinity vascular angiotensin II receptor in rat mesenteric artery. Circ Res 47: 278–286

    PubMed  Google Scholar 

  • Haglund U, Bulkley GB, Granger DN (1987) On the pathophysiology of intestinal ischemic injury. Clinical review. Acta Chir Scand 153: 321–324

    PubMed  CAS  Google Scholar 

  • Harkema JM, Chaudry IH (1990) Oxygen delivery and multiple organ failure. In: Deitch EA (ed) Multiple organ failure: pathophysiology and basic concepts of therapy. Thieme, Stuttgart New York, pp 87–103

    Google Scholar 

  • Hebert PC, Drummond AJ, Singer J, Bernard GR, Russell JA (1993) A simple multiple system organ failure scoring system predicts mortality of patients who have sepsis syndrome. Chest 104: 230–235

    PubMed  CAS  Google Scholar 

  • Hesse DG, Davatelis G, Felsen D (1987) Cachectin/tumor necrosis factor gene expression in Kupffer cells. J Leukoc Biol 42: 422

    Google Scholar 

  • Hesse DG, Tracey KJ, Fong Y et al. (1988) Cytokine appearance in human endotoxemina and primate bacteremia. Surg Gynecol Obstet 166: 147–153

    PubMed  CAS  Google Scholar 

  • James SP, Zeitz M, Kanof M, Kwan WC (1988) Intestinal lymphocyte populations and mechanisms of cell mediated immunity. Immunol Allergy Clin North Am 8: 369–391

    Google Scholar 

  • Janoff A, Scherer J (1968) Mediators of inflammation in leukocyte lysosomes. IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes. J Exp Med 128: 1137–1155

    PubMed  CAS  Google Scholar 

  • Jochum M, Machleidt W, Neuhof H et al. (1993) Porteinases. In: Schlag G, Red IH (eds) Pathophysiology of shock sepsis and organ failure. Springer, Berlin Heidelberg New York Tokyo, pp 55–61

    Google Scholar 

  • Johnson KD, Cadambi A, Seibert GB (1985) Incidence of adult respiratory distress syndrome in patients with multiple musculoskeletal injuries: effect of early operative stabilization of fractures. J Trauma 25: 375–384

    PubMed  CAS  Google Scholar 

  • Jones SC, Trejdosiewicz LK, Banks RE, Howdle PD, Axon AT, Dixon MF, Whicher JT (1993) Expression of interleukin-6 by intestinal enterocytes. J Clin Pathol 46: 1097–1100

    PubMed  CAS  Google Scholar 

  • Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) Prognosis in acute organ-system failure. Ann Surg 202: 685–693

    PubMed  CAS  Google Scholar 

  • Lefer AM, Lefer DJ (1993) Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Ann Rev Pharmacol Toxicol 33: 71–90

    CAS  Google Scholar 

  • Lundgren O, Svanvik J (1973) Mucosal hemodynamics in the small intestine of the cat during reduced perfusion pressure. Acta Physiol Scand 88: 551–563

    PubMed  CAS  Google Scholar 

  • Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ (1995) The mulitple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med (in press)

    Google Scholar 

  • Matuschak GM, Rinaldo JE (1988) Organ interactions in the adult respiratory distress syndrome during sepsis. Role of the liver in host defense. Chest 94: 400–406

    PubMed  CAS  Google Scholar 

  • MacCabe RP, Secrist H, Botney M, Egan M, Peters MG (1993) Cytokine mRNA expression in intestine from normal and inflammatory bowel disease patients. Clin Immunol Immunopathol 66: 52–58

    Google Scholar 

  • McGee DW, Beagley KW, Aicher WK, McGhee JR (1993) Transforming growth factorbeta and IL-1 beta act in synergy to enhance IL-6 secretion by the intestinal epithelial cell line, IEC-6. J Immunol 151: 970–978

    PubMed  CAS  Google Scholar 

  • McMenamy RH, Birkhahn R, Oswald G et al. (1981) Multiple systems organ failure: I. The basal state. J Trauma 21: 99–114

    PubMed  CAS  Google Scholar 

  • McNeill JR, Wilcox WC, Pang CC (1977) Vasopressin and angiotensin: reciprocal mechanisms controlling mesenteric conductance. Am J Physiol 232: H260–H266

    PubMed  CAS  Google Scholar 

  • Meakins JL (1990) Etiology of multiple organ failure. J Trauma 30: S165–S168

    PubMed  CAS  Google Scholar 

  • Moore FA, Moore EE, Poggetti R, McAnena OJ, Peterson VM, Abernathy CM, Parsons PE (1991) Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma. J Trauma 31: 629–636

    PubMed  CAS  Google Scholar 

  • Mulligan MS, Polley MJ, Bayer RJ, Nunn MF, Paulson JC, Ward PA (1992) Neutrophildependent acute lung injury. Requirement for P-selectin (GMP-140). J Clin Invest 90: 1600–1607

    PubMed  CAS  Google Scholar 

  • Nagura H, Sumi Y (1988) Immunological functions of the gut — role of the mucosal immune system. Toxicol Pathol 16: 154–164

    PubMed  CAS  Google Scholar 

  • Nast-Kolb D, Waydhas C, Jochum M, et al. (1992) Biochemische Faktoren als objektive Parameter zur Prognoseabschätzung beim Polytrauma. Unfallchirurg 95: 59–66

    PubMed  CAS  Google Scholar 

  • O’Flaherty JT, Kreutzer DL, Ward PA (1983) Chemotactic influences on the aggregating swelling and foreign surface adhesion of human leukocytes. Am J Pathol 90: 537

    Google Scholar 

  • O’Garra A (1989) Interleukins and the immune system 2. Lancet 1: 1003–1005

    PubMed  Google Scholar 

  • Ogle CK, Johnson C, Guo XL, Ogle JD, Solomkin JS, Alexander JW (1989) Production and release of C3 by cultured monocytes/macrophages isolated from burned, trauma, and septic patients. J Trauma 29: 189–194

    PubMed  CAS  Google Scholar 

  • Pape HC, Dwenger A, Regel G et al. (1992a) Pulmonary damage after intramedullary femoral nailing in traumatized sheep — is there an effect from different nailing methods? J Trauma 33: 574–581

    PubMed  CAS  Google Scholar 

  • Pape HC, Regel G, Sturm JA, Tscherne H (1992b) Ist das posttraumatische Nierenversagen therapeutisch zu beeinflussen? Unfallchirurg 95: 419–425

    PubMed  CAS  Google Scholar 

  • Pape HC, Auf’m’Kolk M, Paffrath T, Regel G, Sturm JA, Tscherne H (1993) Primary intramedullary femur fixation in multiple trauma patients with associated lung contusion — a cause of posttraumatic ARDS? J Trauma 34: 540–547

    PubMed  CAS  Google Scholar 

  • Pape HC, Dwenger A, Regel G et al. (1994) Increased gut permeability after multiple trauma Br J Surg 81: 850–852

    PubMed  CAS  Google Scholar 

  • Phadke AY, Jiandani PG (1993) Mulitple system organ failure: a study of outcome [see comments]. J Assoc Physicians India 91: 498–499

    Google Scholar 

  • Pober JS (1988) Cytokine mediated activation of vascular endothelium. Physiology and pathology. Am J Pathol 133: 76–83

    Google Scholar 

  • Redfors S, Hallback DA, Haglund U, Jodal M, Lundgren O (1984) Blood flow distribution, villous tissue osmolality and fluid and electrolyte transport in the cat small intestine during regional hypotension. Acta Physiol Scand 121: 193–209

    PubMed  CAS  Google Scholar 

  • Regel G, Sturm JA, Friedl HP, Nerlich M, Bosch U, Tscherne H (1988) Die Bedeutung der Lungenkontusion für die Letalität nach Polytrauma. Möglichkeiten der therapeutischen Beeinflussung. Chirurg 59: 771–776

    PubMed  CAS  Google Scholar 

  • Regel G, Dwenger A, Gratz KF, Nerlich ML, Sturm JA, Tscherne H (1989) Humorale und zelluläre Veränderungen der unspezifischen Immunabwehr nach schwerem Traum. Unfallchirurg 92: 314–320

    PubMed  CAS  Google Scholar 

  • Regel G, Seekamp A, Aebert H, Wegener G, Sturm JA (1990) Bronchoscopy in severe blunt chest trauma. Surg Endosc 4: 31–35

    PubMed  CAS  Google Scholar 

  • Regel G, Sturm JA, Pape HC, Gratz KF, Tscherne H (1991) Das Multiorganversagen (MOV). Ausdruck eines generalisierten Zellschadens aller Organe nach schwerem Trauma. Unfallchirurg 94: 487–497

    PubMed  CAS  Google Scholar 

  • Regel G, Grotz M, Weltner T, Sturm JA, Tscherne H (1996) The pattern of organ failure after severe trauma. World J Surg Reinecker HC, Steffen M, Witthoeft T, Pflueger I, Schreiber S, MacDermott RP, Raedler A (1993) Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn’s disease. Clin Exp Immunol 94: 174–181

    Google Scholar 

  • Rosenstreich DL, Vogel SN, Jacques AR, Wahl LM, Oppenheim JJ (1978) Macrophage sensitivity to endotoxin: genetic control by a single condominant gene. J Immunol 121: 1664–1670

    PubMed  CAS  Google Scholar 

  • Rush BF Jr, Sori AJ, Murphy TF, Smith S, Flanagan JJ Jr, Machiedo GW (1988) Endotoxemia and bacteremia during hemorrhagic shock. The link between trauma and sepsis? Ann Surg 207: 549–554

    PubMed  Google Scholar 

  • Rutherford RB, Balis JV, Trow RS, Graves GM (1976) Comparison of hemodynamic and regional blood flow changes at equivalent stages of endotoxin and hemorrhagic shock. J Trauma 16: 886–897

    PubMed  CAS  Google Scholar 

  • Sacco WJ, Milholland AV, Ashman WP et al. (1977) Trauma indices. Comput Biol Med 7: 9–20

    PubMed  CAS  Google Scholar 

  • Salyer JL, Bohnsack JF, Knape WA, Shigeoka AO, Ashwood ER, Hill HR (1990) Mechanisms of tumor necrosis factor-alpha alteration of PMN adhesion and migration. Am J Pathol 136: 831–841

    PubMed  CAS  Google Scholar 

  • Sauaia A, Moore FA, Moore EE, Haenel JB, Read RA, Lezotte DC (1994) Early predictors of postinjury multiple organ failure. Arch Surg 129: 39–45

    PubMed  CAS  Google Scholar 

  • Schindler R, Mancilla J, Endres S, Ghorbani R, Clark SC, Dinarello CA (1990) Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 75: 40–47

    PubMed  CAS  Google Scholar 

  • Schleiffenbaum B, Fehr J (1990) The tumor necrosis factor receptor and human neutrophil function. Deactivation and crossdeactivation of tumor necrosis factor-induced neutrophil responses by receptor down-regulation. J Clin Invest 86: 184–195

    PubMed  CAS  Google Scholar 

  • Schmauder Chock EA, Chock SP, Patchen ML (1994) Ultrastructural localization of tumour necrosis factor-alpha. Histochem J 26: 142–151

    PubMed  Google Scholar 

  • Schreiber S, Raedler A, Stenson WF, MacDermott RP (1992) The role of the mucosal immune system in inflammatory bowel disease. Gastroenterol Clin North Am 21: 451–502

    PubMed  CAS  Google Scholar 

  • Schwartz DB, Bone RC, Balk RA, Szidon JP (1989) Hepatic dysfunction in the adult respiratory distress syndrome. Chest 95: 871–875

    PubMed  CAS  Google Scholar 

  • Schweiberer L, Nast Kolb D, Duswald KH, Waydhas C, Muller K (1987) Das Polytrauma — Behandlung nach dem diagnostischen und therapeutischen Stufenplan. Unfallchirurg 90: 529–538

    PubMed  CAS  Google Scholar 

  • Seekamp A, Mulligan MS, Till GO, Ward PA (1993) Requirements for neutrophil products and L-arginine in ischemia-reperfusion injury. Am J Pathol 142: 1217–1226

    PubMed  CAS  Google Scholar 

  • Seekamp A, Till GO, Mulligan MS, Paulson JC, Anderson DC, Miyasaka M, Ward PA (1994) Role of selectins in local and remote tissue injury following ischemia and reperfusion. Am J Pathol 144: 592–598

    PubMed  CAS  Google Scholar 

  • Shalaby MR, Aggarwal BB, Rinderknecht E, Svedersky LP, Finkle BS, Palladino MA Jr (1985) Activation of human polymorphonudear neutrophil functions by interferon-gamma and tumor necrosis factors. J Immunol 135: 2069–2073

    PubMed  CAS  Google Scholar 

  • Shenkar R, Abraham E (1993) Effects of hemorrhage on cytokine gene transcription. Lymphokine Cytokine Res 12: 237–247

    PubMed  CAS  Google Scholar 

  • Shenkar R, Chang TH, Abraham E (1994) Cytokine expression in Peyer’s patches following hemorrhage and resuscitation. Shock 1: 25–30

    PubMed  CAS  Google Scholar 

  • Solomkin JS, Jenkins BS, Nelson RD, Chenoweth D, Simmons RL (1981) Neutrophil dysfunction in sepsis IV. Evidence for the role of complement activation products in cellular deactivation. Surgery 90: 319

    Google Scholar 

  • Stallone RJ, Herbst J, Blaisdell FW, et al. (1969) Pulmonary changes following ischemia of the lower extremities and their treatment. Am Rev Respir Dis 100: 813–823

    PubMed  CAS  Google Scholar 

  • Stallone RJ, Lim RC Jr, Blaisdell FW (1969) Pathogenesis of the pulmonary changes following ischemia of the lower extremities. Ann Thorac Surg 7: 539–549

    PubMed  CAS  Google Scholar 

  • Strieter RM, Kunkel SL, Showell HJ, Remick DG, Phan SH, Ward PA, Marks RM (1989) Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta. Science 243: 1467–1469

    PubMed  CAS  Google Scholar 

  • Strieter RM, Lynch JP 3d, Basha MA, Standiford TJ, Kasahara K, Kunkel SL (1990) Host responses in mediating sepsis and adult respiratory distress syndrome. Semin Respir Infect 5: 233–247

    PubMed  CAS  Google Scholar 

  • Sturm JA, Wisner DH, Oestern HJ, Kant CJ, Tscherne H, Creutzig H (1986) Increased lung capillary permeability after trauma: a prospective clinical study. J Trauma 26: 409–418

    PubMed  CAS  Google Scholar 

  • Täte RM, Vanbenthuysen KM, Shasby DM, McMurtry IF, Repine JE (1982) Oxygenradical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs. Am Rev Respir Dis 126: 802–806

    PubMed  Google Scholar 

  • Tilney NL, Bailey GL, Morgan AP (1973) Sequential system failure after rupture of abdominal aortic aneurysms: an unsolved problem in postoperative care. Ann Surg 178: 117–122

    PubMed  CAS  Google Scholar 

  • Tracey KJ (1991) Tumor necrosis factor (cachectin) in the biology of septic shock syndrome. Circ Shock 35: 123–128

    PubMed  CAS  Google Scholar 

  • Tracey KJ, Vlassara H, Cerami A (1989) Cachectin/tumour necrosis factor. Lancet 1: 1122–1126

    PubMed  CAS  Google Scholar 

  • Trentz O (1993) Management des Mehrfachverletzten. Ther Umsch 50: 491–499

    PubMed  CAS  Google Scholar 

  • Tscherne H, Regel G, Sturm JA, Friedl HP (1987a) Schweregrad und Prioritäten bei Mehrfachverletzungen. Chirurg 58: 631–640

    PubMed  CAS  Google Scholar 

  • Tscherne H, Sturm JA, Regel G (1987b) Die prognostische Bedeutung der Frühversorgung am Beispiel des Unfallpatienten. Langenbecks Arch Chir 372: 37–42

    PubMed  CAS  Google Scholar 

  • Varani J, Fligiel SE, Till GO, Kunkel RG, Ryan US, Ward PA (1985) Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical. Lab Invest 53: 656–663

    PubMed  CAS  Google Scholar 

  • Waydhas C, Nast-Kolb D, Kick M, et al. (1994) Operationsplanung von sekundären Eingriffen nach Polytrauma. Unfallchirurg 97: 244–249

    PubMed  CAS  Google Scholar 

  • Winn RK, Mihelicic D, Vedder NB, Sharar SR, Harlan JM (1993) Monoclonal antibodies to leukocyte and endothelial adhesion molecules attenuate ischemia-reperfusion injury. Behring Inst Mitt 229-237

    Google Scholar 

  • Yurt RW (1986) Host defenses in trauma general surgery and thermal injury. In: Shires GT, Davis JM (eds) Raven, New York, pp 19–36

    Google Scholar 

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Authors
  1. G. Regel
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  2. M. Grotz
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  3. A. Seekamp
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  1. Unfallchirurgischen Klinik, Medizinische Hochschule Hannover, 30623, Hannover, Germany

    Harald Tscherne (Direktor) & Gerd Regel (Direktor) & 

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Regel, G., Grotz, M., Seekamp, A. (1997). Pathophysiologie. In: Tscherne, H., Regel, G. (eds) Tscherne Unfallchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59215-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-59215-7_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63901-2

  • Online ISBN: 978-3-642-59215-7

  • eBook Packages: Springer Book Archive

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