Abstract
Many investigators consider exercise to be a stimulus for coronary collateral development. According to Schaper (1) the primary factors affecting coronary collateral development include dilation secondary to hypoxia and increased tangential wall stress. Investigators still debate whether these factors occur during prolonged exercise stress. The effect of endurance exercise training, i.e. a decreased heart rate at a given work load, indicates more efficient cardiac function which implies less cardiac stress, thus reducing the stimulus for collateral development. However, chronic exercise training accentuates coronary collateral development when a critical coronary artery stenosis is present (2). To summarize the current knowledge of the interrelationship between exercise and coronary collateral development, we will analyze exercise’s influence on angiogenesis in the heart, discuss different animal models of angiogenesis and indicate what similarities exist in these different models that merit further investigation.
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White, F.C., Roth, D.M., McKirnan, M.D., Carroll, S.M., Bloor, C.M. (1992). Exercise Induced Coronary Collateral Development: A Comparison to Other Models of Myocardial Angiogenesis. In: Schaper, W., Schaper, J. (eds) Collateral Circulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3092-3_13
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DOI: https://doi.org/10.1007/978-1-4615-3092-3_13
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